SNX3 and USP10

Number of citations of the paper that reports this interaction (PMID 18632802)
10

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		SNX3	USP10
Gene Name		sorting nexin 3	ubiquitin specific peptidase 10
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Endosome Membrane Extrinsic Component Of Membrane Clathrin-coated Vesicle Retromer Complex Early Endosome Membrane Early Phagosome Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Nucleus Cytoplasm Early Endosome
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	P53 Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Ion Channel Binding Poly(A) RNA Binding
	Biological Process	Response To Bacterium Membrane Invagination Positive Regulation Of Neuron Projection Development Vesicle Organization Protein To Membrane Docking Regulation Of Wnt Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Protein Transport Transferrin Transport Negative Regulation Of Protein Catabolic Process Hemoglobin Biosynthetic Process Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Phagocytosis Negative Regulation Of Protein Transport Intralumenal Vesicle Formation Negative Regulation Of Early Endosome To Late Endosome Transport	DNA Repair Autophagy Regulation Of Autophagy Protein Deubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways		WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS			Height ( 18391951)
Protein-Protein Interactions		9 interactors: ARL6IP1 BARD1 BRCA1 LIG4 PAXIP1 SCNN1A STX11 USP10 VPS35	9 interactors: AR G3BP1 G3BP2 IKBKG SCNN1A SCNN1G SNX3 TP53 UBC
Entrez ID		8724	9100
HPRD ID		09333	07029
Ensembl ID		ENSG00000112335	ENSG00000103194
Uniprot IDs		O60493	Q14694
PDB IDs		2YPS
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Damage Response, Signal Transduction By P53 Class Mediator Protein K6-linked Ubiquitination Signal Transduction In Response To DNA Damage Cellular Response To DNA Damage Stimulus Signal Transduction By P53 Class Mediator Positive Regulation Of Histone H3-K4 Methylation DNA Metabolic Process Response To Ionizing Radiation Positive Regulation Of Histone Acetylation Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Positive Regulation Of Histone Methylation DNA Recombination Cellular Response To Stress Regulation Of Histone Acetylation Regulation Of Histone Methylation Positive Regulation Of Histone Modification Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H3-K36 Methylation DNA Ligation Involved In DNA Recombination Positive Regulation Of Histone H4-K16 Acetylation Response To Stress Response To Radiation Negative Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone H3-K9 Acetylation Negative Regulation Of Late Endosome To Lysosome Transport Negative Regulation Of Intracellular Transport Regulation Of Histone Modification Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Positive Regulation Of Protein Ubiquitination Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Leukocyte Activation Involved In Immune Response Protein Polyubiquitination Cellular Response To Indole-3-methanol Negative Regulation Of Centriole Replication Lagging Strand Elongation Pro-B Cell Differentiation Negative Regulation Of Protein Export From Nucleus Dosage Compensation By Inactivation Of X Chromosome Neutrophil Degranulation Cytotoxic T Cell Degranulation Regulation Of Chromosome Organization Regulation Of Protein Ubiquitination Establishment Of Integrated Proviral Latency Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation	Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signaling Transport Sodium Ion Homeostasis Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Ras Protein Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Stimulus Regulation Of Establishment Of Protein Localization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Protein Localization Excretion Multicellular Organismal Water Homeostasis Regulation Of Wnt Signaling Pathway Toll-like Receptor 5 Signaling Pathway Positive Regulation Of Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Toll-like Receptor 10 Signaling Pathway Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Signal Transduction Involved In DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Signal Transduction Involved In Cell Cycle Checkpoint Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Apoptotic Process Toll-like Receptor 9 Signaling Pathway Negative Regulation Of Programmed Cell Death Water Homeostasis TRIF-dependent Toll-like Receptor Signaling Pathway Sensory Perception Of Taste MyD88-independent Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Death Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Localization DNA Damage Response, Signal Transduction By P53 Class Mediator
Tagcloud ?		altogether biogenesis degradative depends detachment endocytic endocytosis endosomal endosomes find homology intralumenal knockdown lysosomes maturation multivesicular nexin phosphoinositides prevents px recycling redundant restores retrograde shares snx12 sorting turn vesicles	bioinformatic class collectively crucial experiments function gain implicating inhibit initiation luciferase micrornas mir molecules noncoding oncogenic pancreatic play prediction pro progression promote roles stabilizing suggested suppressed targeting tumorigenesis ups10
Tagcloud (Difference) ?		altogether biogenesis degradative depends detachment endocytic endocytosis endosomal endosomes find homology intralumenal knockdown lysosomes maturation multivesicular nexin phosphoinositides prevents px recycling redundant restores retrograde shares snx12 sorting turn vesicles	bioinformatic class collectively crucial experiments function gain implicating inhibit initiation luciferase micrornas mir molecules noncoding oncogenic pancreatic play prediction pro progression promote roles stabilizing suggested suppressed targeting tumorigenesis ups10
Tagcloud (Intersection) ?