AFTPH and PEX14

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		AFTPH	PEX14
Description		aftiphilin	peroxisomal biogenesis factor 14
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol AP-1 Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm	Fibrillar Center Nucleus Peroxisome Peroxisomal Membrane Cytosol Membrane Protein-containing Complex Peroxisomal Importomer Complex
	Molecular Function	Protein Binding Clathrin Binding	Transcription Corepressor Activity Signaling Receptor Binding Protein Binding Microtubule Binding Protein Transmembrane Transporter Activity Protein-macromolecule Adaptor Activity Identical Protein Binding Beta-tubulin Binding
	Biological Process	Protein Transport Intracellular Transport	Protein Monoubiquitination Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Receptor Recycling Negative Regulation Of Protein Binding Microtubule Anchoring Cellular Response To Reactive Oxygen Species Peroxisome Transport Along Microtubule Protein Unfolding Negative Regulation Of DNA-binding Transcription Factor Activity Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of DNA-templated Transcription Protein-containing Complex Assembly
Pathways			E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Delirium ( 29631748) Lung adenocarcinoma ( 31326317) Metabolite levels ( 23823483)	Asthma ( 34103634 32296059 27182965) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 27117709 23535729 23535733) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 27182965) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Facial morphology ( 31763980) Femur bone mineral density x serum urate levels interaction ( 34046847) Hand grip strength ( 29313844) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Optic nerve measurement (rim area) ( 20395239) Prostate cancer ( 25217961) Refractive error ( 32231278) Self-reported allergy ( 23817569) Total cholesterol levels ( 30275531)
Interacting Genes		11 interacting genes: AP1G1 AP1G2 CLTC GGA1 GGA2 GGA3 LIG4 MAP1LC3B PEX14 STAT5B UBE3A	24 interacting genes: ACACB AFTPH CAMTA1 CBFA2T2 CENPK COPS4 FSD1 GET3 HDAC1 KDM5D MARF1 MED8 MTNR1A NEDD9 NFE2 NFKBIL1 OGT PEX19 PEX26 PEX5 PEX7 SMARCC2 TONSL ZHX1
Entrez ID		54812	5195
HPRD ID		10635	03477
Ensembl ID		ENSG00000119844	ENSG00000142655
Uniprot IDs		A0A8Q3SI61 A0A8Q3SIA4 A0A8Q3WKU6 A0A8Q3WM48 Q53GW0 Q6ULP2	O75381
PDB IDs			2W84 2W85 4BXU 9GAG
Enriched GO Terms of Interacting Partners?		Post-Golgi Vesicle-mediated Transport Intracellular Protein Transport Trans-Golgi Network Golgi Vesicle Transport Protein Localization To Cell Surface Protein Transport Golgi To Plasma Membrane Protein Transport Vesicle-mediated Transport Intracellular Transport Establishment Of Protein Localization Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Cellular Localization Establishment Of Localization In Cell Clathrin-coated Vesicle Small GTPase Binding Endosome Membrane AP-1 Adaptor Complex Intracellular Protein Localization Ubiquitin Binding Phosphatidylinositol Binding Clathrin Adaptor Activity Endosome Golgi To Vacuole Transport Cytosolic Transport Intracellular Vesicle Vesicle-mediated Transport To The Plasma Membrane Protein-containing Complex Disassembly Vacuolar Transport Membrane Coat Cytoplasmic Vesicle Membrane Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Protein Localization To Plasma Membrane Positive Regulation Of Natural Killer Cell Mediated Immunity Early Endosome Membrane Establishment Of Protein Localization To Membrane T Cell Differentiation In Thymus Protein Localization To Cell Periphery Regulation Of Natural Killer Cell Mediated Cytotoxicity Endosomal Transport Regulation Of Natural Killer Cell Mediated Immunity Establishment Of Integrated Proviral Latency Peroxisome Transport Along Microtubule Sperm Entry Positive Regulation Of Golgi Lumen Acidification Positive Regulation Of Leukocyte Mediated Cytotoxicity Golgi Apparatus Positive Regulation Of Cell Killing Protein Localization To Membrane Clathrin-coated Pit	Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Organization Protein Import Into Peroxisome Membrane Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Peroxisome Peroxisomal Membrane Peroxisome Membrane Targeting Sequence Binding Nucleoplasm Intracellular Protein Transmembrane Transport Protein Carrier Chaperone Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Nucleus Fatty Acid Oxidation Establishment Of Protein Localization To Membrane Protein Transmembrane Transport Protein Localization To Organelle Lipid Oxidation Nucleosome Disassembly Sin3-type Complex Protein-DNA Complex Disassembly Protein-containing Complex Negative Regulation Of Stem Cell Population Maintenance Receptor Recycling Circadian Rhythm Chromatin Organization Lipid Modification Regulation Of Androgen Receptor Signaling Pathway Protein-containing Complex Disassembly Lactic Acid Secretion Intracellular Aspartate Homeostasis Nucleosomal DNA Binding Establishment Of Protein Localization To Organelle Peroxisome Matrix Targeting Signal-2 Binding Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Receptor Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Peroxisomal Matrix Malonyl-CoA Biosynthetic Process Protein-containing Complex Organization Acetyl-CoA Carboxylase Activity Krueppel-associated Box Domain Binding Positive Regulation Of Immunological Synapse Formation Fatty Acid Beta-oxidation Peroxisome Matrix Targeting Signal-1 Binding
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