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AFTPH and STAT5B
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
AFTPH
STAT5B
Gene Name
aftiphilin
signal transducer and activator of transcription 5B
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
AP-1 Adaptor Complex
Intracellular Membrane-bounded Organelle
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Clathrin Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Chromatin Binding
Double-stranded DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Signal Transducer Activity
Protein Binding
Protein Phosphatase Binding
Glucocorticoid Receptor Binding
Protein Dimerization Activity
Biological Process
Protein Transport
Allantoin Metabolic Process
Luteinization
Response To Hypoxia
Natural Killer Cell Differentiation
Liver Development
Citrate Metabolic Process
2-oxoglutarate Metabolic Process
Succinate Metabolic Process
Oxaloacetate Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Isoleucine Metabolic Process
Valine Metabolic Process
Creatine Metabolic Process
Fatty Acid Metabolic Process
Acute-phase Response
JAK-STAT Cascade
Female Pregnancy
Lactation
Regulation Of Steroid Metabolic Process
Taurine Metabolic Process
Lipid Storage
Regulation Of Epithelial Cell Differentiation
Response To Estradiol
Response To Lipopolysaccharide
Positive Regulation Of Natural Killer Cell Proliferation
Positive Regulation Of Natural Killer Cell Differentiation
Cellular Response To Hormone Stimulus
T Cell Differentiation In Thymus
Prolactin Signaling Pathway
Regulation Of Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
Positive Regulation Of Activated T Cell Proliferation
Progesterone Metabolic Process
T Cell Homeostasis
Negative Regulation Of Apoptotic Process
Positive Regulation Of Interleukin-2 Biosynthetic Process
Response To Ethanol
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Negative Regulation Of Erythrocyte Differentiation
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Creatinine Metabolic Process
Development Of Secondary Female Sexual Characteristics
Development Of Secondary Male Sexual Characteristics
Peyer's Patch Development
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Inflammatory Response
Positive Regulation Of Cellular Component Movement
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Response To Interleukin-2
Response To Interleukin-4
Response To Interleukin-15
Cellular Response To Growth Factor Stimulus
Cellular Response To Epidermal Growth Factor Stimulus
Pathways
Signaling by PDGF
Signaling by FGFR in disease
Cytokine Signaling in Immune system
Signaling by ERBB4
Signaling by SCF-KIT
Signaling by Interleukins
Nuclear signaling by ERBB4
Downstream signal transduction
Signaling by FGFR1 mutants
Interleukin-7 signaling
Signaling by FGFR mutants
Interleukin-2 signaling
Prolactin receptor signaling
Signaling by FGFR1 fusion mutants
Interleukin-3, 5 and GM-CSF signaling
Signaling by Leptin
Growth hormone receptor signaling
Drugs
Dasatinib
Diseases
GWAS
Inflammatory bowel disease (
23128233
)
Protein-Protein Interactions
8 interactors:
AP1G1
AP1G2
GGA1
GGA2
GGA3
LIG4
STAT5B
UBE3A
49 interactors:
AFTPH
APP
CBL
CD247
CENPJ
CRK
CRKL
CTLA4
CXCR4
DMRTA1
EGFR
ELP2
EP300
EPOR
ERBB4
ETS1
ETS2
GHR
HAX1
IL15
IL2RA
IL2RB
IL7R
INSR
JAK2
JAK3
KIT
MAPK1
NCOR2
NMI
NR3C1
PDGFRA
PDGFRB
POU2F1
PPP2CA
PTPN1
PTPN11
PTPN2
PTPN6
RARA
SERTAD1
SHC1
SRC
STAP2
STAT1
STAT3
STAT5A
TEK
TFG
Entrez ID
54812
6777
HPRD ID
10635
05037
Ensembl ID
ENSG00000119844
ENSG00000173757
Uniprot IDs
Q53GW0
Q6ULP2
P51692
PDB IDs
Enriched GO Terms of Interacting Partners
?
Vesicle-mediated Transport
Intracellular Protein Transport
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Natural Killer Cell Mediated Immunity
Viral Process
Regulation Of Natural Killer Cell Mediated Cytotoxicity
Regulation Of Natural Killer Cell Mediated Immunity
Cellular Protein Localization
Positive Regulation Of Natural Killer Cell Activation
Protein Transport
Establishment Of Protein Localization
Intracellular Transport
Transport
Protein Localization
Establishment Of Localization In Cell
Regulation Of Protein Catabolic Process
T Cell Differentiation In Thymus
Sperm Entry
DNA Ligation Involved In DNA Recombination
Cellular Localization
Ovulation Cycle Process
Positive Regulation Of Leukocyte Mediated Cytotoxicity
Positive Regulation Of Cell Killing
Regulation Of Leukocyte Mediated Cytotoxicity
Female Gonad Development
Ovulation Cycle
Development Of Primary Female Sexual Characteristics
Positive Regulation Of Natural Killer Cell Degranulation
Golgi To Lysosome Transport
T Cell Differentiation
Creatinine Metabolic Process
Development Of Secondary Male Sexual Characteristics
Positive Regulation Of Innate Immune Response
Isoleucine Metabolic Process
Allantoin Metabolic Process
Positive Regulation Of Natural Killer Cell Proliferation
Lagging Strand Elongation
Pro-B Cell Differentiation
Positive Regulation Of Protein Catabolic Process
Taurine Metabolic Process
Regulation Of Natural Killer Cell Proliferation
Prolactin Signaling Pathway
Response To Interleukin-15
Golgi To Vacuole Transport
Establishment Of Integrated Proviral Latency
Gonad Development
Development Of Primary Sexual Characteristics
Lymphocyte Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Pigment Granule Maturation
Cellular Response To Organic Substance
Response To Organic Substance
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Immune Response
Response To Hormone
Regulation Of MAPK Cascade
Regulation Of Immune System Process
Regulation Of Kinase Activity
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cellular Metabolic Process
Response To Cytokine
Cell Surface Receptor Signaling Pathway
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Regulation Of Phosphorylation
Regulation Of Signal Transduction
Growth Hormone Receptor Signaling Pathway
Regulation Of Protein Phosphorylation
Cellular Response To Hormone Stimulus
Cellular Response To Growth Hormone Stimulus
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Immune Response
Signaling
Regulation Of Phosphorus Metabolic Process
Signal Transduction
JAK-STAT Cascade
Positive Regulation Of MAPK Cascade
Defense Response
Cell Communication
Regulation Of Signaling
Cellular Response To Organonitrogen Compound
Positive Regulation Of Metabolic Process
Immune System Process
Cellular Response To Cytokine Stimulus
Cellular Response To Peptide Hormone Stimulus
Positive Regulation Of Kinase Activity
Regulation Of Cellular Ketone Metabolic Process
Organ Development
Cellular Response To Peptide
Response To Growth Hormone
Positive Regulation Of Phosphorylation
Cellular Response To Stimulus
Regulation Of Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Regulation Of Protein Metabolic Process
Response To Peptide Hormone
Positive Regulation Of Transferase Activity
Innate Immune Response
Tagcloud
?
augment
augments
bait
cbp
coactivator
coil
coiled
enhances
except
hybrid
ifngamma
instead
interactor
interacts
interestingly
intrinsic
lacks
myc
nmi
potentiate
recruitment
reveal
screen
stat1
stat2
stats
yeast
Tagcloud (Difference)
?
augment
augments
bait
cbp
coactivator
coil
coiled
enhances
except
hybrid
ifngamma
instead
interactor
interacts
interestingly
intrinsic
lacks
myc
nmi
potentiate
recruitment
reveal
screen
stat1
stat2
stats
yeast
Tagcloud (Intersection)
?