KIF3A and PPP1R15A

Number of citations of the paper that reports this interaction (PubMedID 10631107)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		KIF3A	PPP1R15A
Description		kinesin family member 3A	protein phosphatase 1 regulatory subunit 15A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Kinesin Complex Microtubule Spindle Microtubule Cilium Microtubule Cytoskeleton Kinesin II Complex Cell Projection Extracellular Exosome Ciliary Tip Axon Cytoplasm	Protein Phosphatase Type 1 Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Cytoskeletal Protein Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Protein Phosphatase Binding Spectrin Binding Small GTPase Binding Protein-containing Complex Binding	Protein Binding Protein Phosphatase 1 Binding Protein Phosphatase Regulator Activity Protein Kinase Binding Eukaryotic Initiation Factor EIF2 Binding Protein Phosphatase Activator Activity
	Biological Process	Organelle Organization Microtubule-based Movement Anterograde Axonal Transport Centriole-centriole Cohesion Transport Along Microtubule Protein Transport Cell Projection Organization Microtubule Anchoring At Centrosome Cilium Assembly Plus-end-directed Vesicle Transport Along Microtubule Protein Localization To Cell Junction	Regulation Of Translation Regulation Of Translational Initiation Apoptotic Process DNA Damage Response Positive Regulation Of Translational Initiation In Response To Stress Response To Endoplasmic Reticulum Stress Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein Localization To Endoplasmic Reticulum Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of PERK-mediated Unfolded Protein Response
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Hedgehog 'off' state Intraflagellar transport Activation of SMO Activation of SMO COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins	Downregulation of TGF-beta receptor signaling Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 31619474 31959851) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 22197932 23042114 25574825 26482879) Atopic march ( 26542096) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Refractive error ( 32231278)	High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		21 interacting genes: APP BTG3 DISC1 DSCAM DSCR9 GRB2 HUNK KIF3B KIF3C LIG4 MAP3K10 MAP3K11 MORC3 NEK1 NRIP1 PLEKHA5 PPP1R15A RPGR TRIM14 TULP3 VHL	16 interacting genes: BAG1 BCAR1 CTBP2 EIF2S1 HABP4 HSPA1A KIF3A KMT2A LYN POU3F3 PPP1CA PPP1R1A RAD21 SMARCB1 TSN ZNF512B
Entrez ID		11127	23645
HPRD ID		05250	06572
Ensembl ID		ENSG00000131437	ENSG00000087074
Uniprot IDs		B4DHG8 E9PES4 J3KPF9 Q05CT3 Q9Y496	O75807
PDB IDs			4XPN 7NXV 7NZM 8QZZ
Enriched GO Terms of Interacting Partners?		Cilium Kinesin Complex JUN Kinase Kinase Kinase Activity Centrosome Positive Regulation Of JUN Kinase Activity Amyloid-beta Complex Positive Regulation Of Metabolic Process Axon Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Plasma Membrane Bounded Cell Projection Organization Central Nervous System Development Regulation Of JNK Cascade Regulation Of Response To Calcium Ion Transport Along Microtubule Amylin Binding Positive Regulation Of JNK Cascade Ephrin Receptor Binding Positive Regulation Of Toll Signaling Pathway Amyloid Fibril Formation Microtubule-based Process Protein Serine/threonine Kinase Binding Cytoplasm Microtubule-based Movement Positive Regulation Of Axon Extension Guanyl-nucleotide Exchange Factor Adaptor Activity ATP Binding Microtubule Establishment Of Integrated Proviral Latency Positive Regulation Of MAP Kinase Activity Phosphorylation Peptidyl-serine Phosphorylation Protein Serine Kinase Activity Protein Phosphorylation Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Cilium Assembly Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Cilium Organization Ciliary Base Ovarian Follicle Rupture Neuron Recognition Ciliary Tip Molecular Adaptor Activity Intraciliary Transport Cell Projection Organization Cytoskeleton-dependent Intracellular Transport Acetylcholine Receptor Activator Activity PTB Domain Binding	Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Translational Initiation In Response To Stress Cellular Response To Heat Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Response To Heat Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Translational Initiation Viral Genome Replication Regulation Of Translation In Response To Stress Protein-containing Complex Binding Response To Temperature Stimulus Nucleus Negative Regulation Of Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Translation Initiation Ternary Complex Regulation Of Erythrocyte Differentiation Positive Regulation Of RNA Splicing Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Metanephric DCT Cell Differentiation Cell Division Metanephric Macula Densa Development Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Transcription Initiation-coupled Chromatin Remodeling B Cell Receptor Signaling Pathway Positive Regulation Of Gene Expression, Epigenetic Regulation Of Metabolic Process Protein Stabilization Positive Regulation Of Apoptotic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Programmed Cell Death Glycogen Metabolic Process Positive Regulation Of Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Protein Metabolic Process Denatured Protein Binding Positive Regulation Of Oligodendrocyte Progenitor Proliferation Circadian Regulation Of Gene Expression Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity Metanephric Thick Ascending Limb Development
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