KIF3A and MAP3K10

Number of citations of the paper that reports this interaction (PMID 9427749)
54

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		KIF3A	MAP3K10
Gene Name		kinesin family member 3A	mitogen-activated protein kinase kinase kinase 10
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Cytosol Spindle Microtubule Microtubule Cytoskeleton Kinesin II Complex Extracellular Vesicular Exosome Primary Cilium Ciliary Tip	Cytoplasm
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity Spectrin Binding	Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity ATP Binding Protein Homodimerization Activity BHLH Transcription Factor Binding
	Biological Process	Organelle Organization Microtubule-based Movement Blood Coagulation Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neurogenesis Cilium Assembly Cilium Morphogenesis Membrane Organization Plus-end-directed Vesicle Transport Along Microtubule	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways		Organelle biogenesis and maintenance Hedgehog 'off' state Kinesins Translocation of GLUT4 to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Intraflagellar transport Hedgehog 'on' state MHC class II antigen presentation Signaling by Hedgehog Adaptive Immune System Activation of SMO
Drugs
Diseases
GWAS		Atopic dermatitis ( 23042114 22197932)
Protein-Protein Interactions		13 interactors: APP DISC1 GRB2 KIF3B KIF3C LIG4 MAP3K10 MAP3K11 NEK1 PLEKHA5 PPP1R15A RPGR VHL	30 interactors: ABL2 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS HGS HTT KIAA1804 KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB RAC1 RACGAP1 SH3RF1 TUBB YWHAE
Entrez ID		11127	4294
HPRD ID		05250	02533
Ensembl ID		ENSG00000131437	ENSG00000130758
Uniprot IDs		E9PES4 J3KPF9 Q05CT3 Q9Y496	Q02779
PDB IDs			2RF0
Enriched GO Terms of Interacting Partners?		Microtubule-based Transport Response To Stress Cytoskeleton-dependent Intracellular Transport Microtubule-based Process Cellular Response To Stress Activation Of JNKK Activity Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Microtubule-based Movement Positive Regulation Of Protein Metabolic Process Response To Stimulus Regulation Of Phosphorylation Activation Of MAPK Activity Response To Ionizing Radiation Blood Coagulation Hemostasis Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Protein Modification Process Response To Radiation Positive Regulation Of Catalytic Activity Cell Death Death Cell Morphogenesis Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Positive Regulation Of MAP Kinase Activity Regulation Of Body Fluid Levels Activation Of JUN Kinase Activity MAPK Cascade Wound Healing Regulation Of Signal Transduction Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Axon Cargo Transport Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Organelle Transport Along Microtubule Signal Transduction By Phosphorylation Response To Wounding Neuron Apoptotic Process Positive Regulation Of Protein Phosphorylation Regulation Of MAP Kinase Activity Regulation Of Signaling Regulation Of Protein Kinase Activity Developmental Process Activation Of MAPKK Activity Regulation Of Protein Metabolic Process	Regulation Of Intracellular Signal Transduction Movement Of Cell Or Subcellular Component Signal Transduction Regulation Of Signal Transduction Regulation Of Stress-activated MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Signaling Regulation Of Signaling Cell Communication Neurogenesis Cell Differentiation Regulation Of JNK Cascade Generation Of Neurons Positive Regulation Of Signal Transduction Blood Coagulation Hemostasis Regulation Of MAPK Cascade Organelle Organization Cellular Localization Cellular Response To Stimulus Neuron Differentiation Response To Stimulus Regulation Of Apoptotic Process Developmental Process Organelle Transport Along Microtubule Regulation Of Phosphorus Metabolic Process MAPK Cascade Response To Stress Intracellular Transport Regulation Of Cell Death Protein Localization Nervous System Development Cytoskeleton-dependent Intracellular Transport Regulation Of Body Fluid Levels Positive Regulation Of Intracellular Signal Transduction Plus-end-directed Vesicle Transport Along Microtubule Wound Healing Regulation Of Catalytic Activity Signal Transduction By Phosphorylation Membrane Organization Transport JNK Cascade Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Microtubule-based Movement Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Vesicle Transport Along Microtubule Response To Wounding
Tagcloud ?		aberrant activate advanced anchorage axis benign biopsies catenin causal ck1 correlate dvl2 exogenous gleason hef1 inactivation kinesin mechanistically mmp9 node notion promoted prostate rarely silencing transactivation upregulated upregulation wnt	artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Difference) ?		aberrant activate advanced anchorage axis benign biopsies catenin causal ck1 correlate dvl2 exogenous gleason hef1 inactivation kinesin mechanistically mmp9 node notion promoted prostate rarely silencing transactivation upregulated upregulation wnt	artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Intersection) ?