KIF3A

Description		kinesin family member 3A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Kinesin Complex Microtubule Spindle Microtubule Cilium Microtubule Cytoskeleton Kinesin II Complex Cell Projection Extracellular Exosome Ciliary Tip Axon Cytoplasm
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Cytoskeletal Protein Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Protein Phosphatase Binding Spectrin Binding Small GTPase Binding Protein-containing Complex Binding
	Biological Process	Organelle Organization Microtubule-based Movement Anterograde Axonal Transport Centriole-centriole Cohesion Transport Along Microtubule Protein Transport Cell Projection Organization Microtubule Anchoring At Centrosome Cilium Assembly Plus-end-directed Vesicle Transport Along Microtubule Protein Localization To Cell Junction
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Hedgehog 'off' state Intraflagellar transport Activation of SMO Activation of SMO COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 31619474 31959851) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 22197932 23042114 25574825 26482879) Atopic march ( 26542096) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Refractive error ( 32231278)
Interacting Genes		21 interacting genes: APP BTG3 DISC1 DSCAM DSCR9 GRB2 HUNK KIF3B KIF3C LIG4 MAP3K10 MAP3K11 MORC3 NEK1 NRIP1 PLEKHA5 PPP1R15A RPGR TRIM14 TULP3 VHL
Entrez ID		11127
HPRD ID		05250
Ensembl ID		ENSG00000131437
Uniprot IDs		B4DHG8 E9PES4 J3KPF9 Q05CT3 Q9Y496
PDB IDs
Enriched GO Terms of Interacting Partners?		Cilium Kinesin Complex JUN Kinase Kinase Kinase Activity Centrosome Positive Regulation Of JUN Kinase Activity Amyloid-beta Complex Positive Regulation Of Metabolic Process Axon Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Plasma Membrane Bounded Cell Projection Organization Central Nervous System Development Regulation Of JNK Cascade Regulation Of Response To Calcium Ion Transport Along Microtubule Amylin Binding Positive Regulation Of JNK Cascade Ephrin Receptor Binding Positive Regulation Of Toll Signaling Pathway Amyloid Fibril Formation Microtubule-based Process Protein Serine/threonine Kinase Binding Cytoplasm Microtubule-based Movement Positive Regulation Of Axon Extension Guanyl-nucleotide Exchange Factor Adaptor Activity ATP Binding Microtubule Establishment Of Integrated Proviral Latency Positive Regulation Of MAP Kinase Activity Phosphorylation Peptidyl-serine Phosphorylation Protein Serine Kinase Activity Protein Phosphorylation Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Cilium Assembly Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Cilium Organization Ciliary Base Ovarian Follicle Rupture Neuron Recognition Ciliary Tip Molecular Adaptor Activity Intraciliary Transport Cell Projection Organization Cytoskeleton-dependent Intracellular Transport Acetylcholine Receptor Activator Activity PTB Domain Binding
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