KIF3A and PLEKHA5

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		KIF3A	PLEKHA5
Gene Name		kinesin family member 3A	pleckstrin homology domain containing, family A member 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Cytosol Spindle Microtubule Microtubule Cytoskeleton Kinesin II Complex Extracellular Vesicular Exosome Primary Cilium Ciliary Tip	Cytosol Membrane
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity Spectrin Binding	Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Organelle Organization Microtubule-based Movement Blood Coagulation Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neurogenesis Cilium Assembly Cilium Morphogenesis Membrane Organization Plus-end-directed Vesicle Transport Along Microtubule	Biological_process Reproductive System Development
Pathways		Organelle biogenesis and maintenance Hedgehog 'off' state Kinesins Translocation of GLUT4 to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Intraflagellar transport Hedgehog 'on' state MHC class II antigen presentation Signaling by Hedgehog Adaptive Immune System Activation of SMO
Drugs
Diseases
GWAS		Atopic dermatitis ( 23042114 22197932)
Protein-Protein Interactions		13 interactors: APP DISC1 GRB2 KIF3B KIF3C LIG4 MAP3K10 MAP3K11 NEK1 PLEKHA5 PPP1R15A RPGR VHL	30 interactors: ARHGEF9 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX PDZD11 PLEC PLEKHA6 PPP1R13B PROM1 SH3BP5L SOGA1 SPTAN1 SPTBN1 UPF1 WASH2P YWHAG
Entrez ID		11127	54477
HPRD ID		05250	09684
Ensembl ID		ENSG00000131437	ENSG00000052126
Uniprot IDs		E9PES4 J3KPF9 Q05CT3 Q9Y496	Q9HAU0
PDB IDs			2DKP
Enriched GO Terms of Interacting Partners?		Microtubule-based Transport Response To Stress Cytoskeleton-dependent Intracellular Transport Microtubule-based Process Cellular Response To Stress Activation Of JNKK Activity Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Microtubule-based Movement Positive Regulation Of Protein Metabolic Process Response To Stimulus Regulation Of Phosphorylation Activation Of MAPK Activity Response To Ionizing Radiation Blood Coagulation Hemostasis Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Protein Modification Process Response To Radiation Positive Regulation Of Catalytic Activity Cell Death Death Cell Morphogenesis Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Positive Regulation Of MAP Kinase Activity Regulation Of Body Fluid Levels Activation Of JUN Kinase Activity MAPK Cascade Wound Healing Regulation Of Signal Transduction Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Axon Cargo Transport Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Organelle Transport Along Microtubule Signal Transduction By Phosphorylation Response To Wounding Neuron Apoptotic Process Positive Regulation Of Protein Phosphorylation Regulation Of MAP Kinase Activity Regulation Of Signaling Regulation Of Protein Kinase Activity Developmental Process Activation Of MAPKK Activity Regulation Of Protein Metabolic Process	Apoptotic Process Programmed Cell Death Cell Death Death Hemidesmosome Assembly Glomerular Visceral Epithelial Cell Differentiation Regulation Of Protein Complex Disassembly Cellular Localization Regulation Of Cellular Component Organization Movement Of Cell Or Subcellular Component Cellular Process Retina Development In Camera-type Eye Organelle Organization Generation Of Neurons Cell Differentiation Involved In Kidney Development Neuron Differentiation Cytoskeleton Organization Regulation Of Actin Filament Polymerization Microtubule-based Process Neurogenesis Metanephric Glomerular Basement Membrane Development Axon Extension Involved In Regeneration Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cell-substrate Junction Assembly Actin Filament Capping Membrane Organization Regulation Of Cytoskeleton Organization Glomerulus Development Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Actin Filament Depolymerization Epithelial Cell Differentiation Regulation Of Organelle Organization Metanephric Glomerular Visceral Epithelial Cell Development Response To Axon Injury Protein Localization Neuron Development Regulation Of Actin Filament Depolymerization Execution Phase Of Apoptosis Negative Regulation Of Actin Filament Polymerization Sensory Organ Development Glomerular Parietal Epithelial Cell Differentiation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Centriole-centriole Cohesion Response To Insulin Establishment Of Localization In Cell Microtubule-based Movement Intracellular Transport Negative Regulation Of Protein Polymerization Post-Golgi Vesicle-mediated Transport
Tagcloud ?		aberrant activate advanced anchorage axis benign biopsies catenin causal ck1 correlate dvl2 exogenous gleason hef1 inactivation kinesin mechanistically mmp9 node notion promoted prostate rarely silencing transactivation upregulated upregulation wnt	a375 a375br a375p aberrantly barrier bbb brain cerebrotropic constructed differentially extra homing immunofluorescence knock mediators melanoma metastases metastasis metastatic overwhelming parental passage profiles profiling propensity subjected transmigration viability yumul
Tagcloud (Difference) ?		aberrant activate advanced anchorage axis benign biopsies catenin causal ck1 correlate dvl2 exogenous gleason hef1 inactivation kinesin mechanistically mmp9 node notion promoted prostate rarely silencing transactivation upregulated upregulation wnt	a375 a375br a375p aberrantly barrier bbb brain cerebrotropic constructed differentially extra homing immunofluorescence knock mediators melanoma metastases metastasis metastatic overwhelming parental passage profiles profiling propensity subjected transmigration viability yumul
Tagcloud (Intersection) ?