AP2B1 and AP1M1

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (biochemical)
HPRD (two hybrid)

		AP2B1	AP1M1
Description		adaptor related protein complex 2 subunit beta 1	adaptor related protein complex 1 subunit mu 1
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Endomembrane System Membrane Membrane Coat Clathrin Coat AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Synapse Clathrin-coated Endocytic Vesicle Postsynaptic Endocytic Zone Extrinsic Component Of Presynaptic Endocytic Zone Membrane Glutamatergic Synapse	Golgi Membrane Lysosomal Membrane Early Endosome Golgi Apparatus Cytosol Plasma Membrane Membrane AP-1 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Specific Granule Membrane Synapse Extracellular Exosome
	Molecular Function	Signal Sequence Binding Protein Binding Clathrin Binding Clathrin Adaptor Activity Protein-containing Complex Binding	Protein Binding Clathrin Adaptor Activity
	Biological Process	Kidney Development Cardiac Septum Development Ventricular Septum Development Intracellular Protein Transport Endocytosis Chemical Synaptic Transmission Neurotransmitter Secretion Heart Development Protein Transport Vesicle-mediated Transport Aorta Development Positive Regulation Of Endocytosis Clathrin Coat Assembly Synaptic Vesicle Endocytosis Coronary Vasculature Development Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Protein Localization To Membrane	Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Melanosome Organization Endosome To Melanosome Transport Platelet Dense Granule Organization Melanosome Assembly
Pathways		Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation
Drugs
Diseases
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 22139419 27863252 32888494) Mean reticulocyte volume ( 32888494) Platelet count ( 22139419 27863252) Platelet distribution width ( 27863252) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Coronary artery disease ( 33020668)
Interacting Genes		60 interacting genes: - ACVR1 AFF4 AP1M1 AP1M2 AP2A2 AP2M1 AP2S1 APC ARF6 ARRB1 ATM ATP23 ATP6V1G1 BUB1 BUB1B CATSPERT CCDC187 CEBPA CLINT1 COL3A1 DHX58 DNAJC5 DSCAM FMNL2 GPANK1 GTF2I HIP1 HPCA HSPB1 KANK2 KIAA0408 KPNA2 LDLRAP1 LONRF1 MEA1 MLH1 NECAP2 NEU4 NUP54 PIP5K1C POM121 PSORS1C2 RAPGEF3 RIBC2 SLC25A6 SLC2A8 SMAD4 SMURF1 SNAP91 TENT5C TERF2IP TEX12 TGFBR1 TGFBR2 THAP1 TUBGCP4 TXN2 U2AF1 UBC	103 interacting genes: AMOT AP1M2 AP2B1 ARFRP1 ARL6IP4 ARNT2 ATF4 AXIN2 BACH2 BCAR3 BRCA1 C7orf57 CASP8 CCDC33 CEP57L1 CORO7 CTLA4 DCX DISC1 DVL2 DZIP3 EFEMP2 EHD2 ENTR1 ETV6 EVI5L FAM219B FAM9B FKBP7 FXR1 FXR2 GAK GCSAM GRIN2A GRIN2B HNRNPC HOOK1 HOOK2 IKZF1 KIF13A KIF24 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 LAMP1 LDOC1 LNX1 LRATD2 LRMDA LZTS1 LZTS2 MDK MEA1 MID2 MTF1 MYOD1 NECAB1 NKAP NKAPD1 OLIG3 PAX6 PHC2 PICK1 PIGR PNMA5 PURB RAPGEF3 ROPN1 RP9 RSPH14 RUNDC3A SDCBP2 SELP SLC2A4 SP4 SPATA6 SRPK2 SSX2IP TEPSIN TFIP11 TGOLN2 THAP6 TIFA TNIP1 TRIM27 TRIM41 UBC VAMP4 VANGL2 ZBTB14 ZBTB3 ZBTB43 ZBTB44 ZBTB8A ZCCHC17 ZNF19 ZNF219 ZNF276 ZNF552 ZNF655 ZNF8 ZSCAN16
Entrez ID		163	8907
HPRD ID		03015	04639
Ensembl ID		ENSG00000006125	ENSG00000072958
Uniprot IDs		A0A140VJE8 P63010 Q96EL6	B3KNH5 Q59EK3 Q9BXS5
PDB IDs		1E42 2G30 2IV8 2IV9 2JKR 2JKT 2VGL 2XA7 4UQI 5M5R 6QH5 6QH6 6QH7 6URI 6YAE 6YAF 6YAH 6YAI 7OG1 7OHO 7OM8 7Z5C
Enriched GO Terms of Interacting Partners?		Clathrin Adaptor Activity SMAD Binding Clathrin Adaptor Complex Clathrin-dependent Endocytosis Clathrin-coated Pit Synaptic Vesicle Endocytosis Regulation Of Receptor-mediated Endocytosis Presynaptic Endocytosis Endocytosis Clathrin Coat Assembly Vesicle-mediated Transport In Synapse Activin Receptor Complex Activin Receptor Activity, Type I Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Activin Receptor Signaling Pathway Receptor-mediated Endocytosis Mitotic Spindle Assembly Checkpoint Signaling Intracellular Protein Transport Clathrin-coated Endocytic Vesicle Membrane Negative Regulation Of Mitotic Metaphase/anaphase Transition Activin Binding Endocytic Vesicle Membrane AP-2 Adaptor Complex Receptor Internalization Clathrin-coated Vesicle Membrane Clathrin Binding Protein Transport Transmembrane Receptor Protein Serine/threonine Kinase Activity Clathrin-coated Vesicle Negative Regulation Of Chromosome Organization Ventricular Septum Morphogenesis Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of SMAD Protein Signal Transduction Import Into Cell Regulation Of Endocytosis Vesicle-mediated Transport I-SMAD Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA-dependent Protein Kinase Activity Transforming Growth Factor Beta Ligand-receptor Complex Transforming Growth Factor Beta Receptor Signaling Pathway Endolysosome Membrane Positive Regulation Of Receptor-mediated Endocytosis Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Cellular Component Organization Establishment Of Protein Localization Positive Regulation Of Cellular Component Organization Intracellular Protein Localization	Identical Protein Binding Protein Binding Zinc Ion Binding Regulation Of RNA Metabolic Process DNA Binding Post-Golgi Vesicle-mediated Transport Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Domain Specific Binding Convergent Extension Involved In Neural Plate Elongation Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Trans-Golgi Network Membrane Regulation Of Transcription By RNA Polymerase II Clathrin-coated Endocytic Vesicle Cellular Localization Intracellular Transport Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Synaptic Plasticity Negative Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Protein Complex Involved In Cell Adhesion Microtubule Convergent Extension Involved In Organogenesis Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion FHF Complex Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Regulatory T Cell Differentiation Convergent Extension Involved In Gastrulation Dentate Gyrus Development Protein Localization To Membrane Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity NMDA Glutamate Receptor Activity Regulation Of RNA Biosynthetic Process
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