AP2B1 and AP2A2

Number of citations of the paper that reports this interaction (PMID 12086608)
139

Data Source:
HPRD (in vitro)

		AP2B1	AP2A2
Gene Name		adaptor-related protein complex 2, beta 1 subunit	adaptor-related protein complex 2, alpha 2 subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle	Cytosol Plasma Membrane Cytoplasmic Membrane-bounded Vesicle AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane
	Molecular Function	Signal Sequence Binding Protein Binding Protein Transporter Activity Clathrin Binding Clathrin Adaptor Activity	Molecular_function Protein Binding Lipid Binding Protein Transporter Activity Protein Kinase Binding Clathrin Adaptor Activity
	Biological Process	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis
Pathways		Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System	Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419) Platelet counts ( 22139419)
Protein-Protein Interactions		44 interactors: ACVR1 AFF4 AP1M1 AP1M2 AP2A2 AP2M1 AP2S1 APC ARRB1 ATM ATP6V1G1 BUB1 BUB1B CLINT1 CLTC DHX58 FAM46C GTF2I HIP1 ITSN1 KIAA0408 KPNA2 LDLRAP1 MEA1 MLH1 NECAP2 NEU4 NUP54 PIP5K1C POM121 RAPGEF3 RIBC2 SLC25A6 SMAD4 SMURF1 SNAP91 TERF2IP TGFBR1 TGFBR2 THAP1 TUBGCP4 TXN2 U2AF1 XRCC6BP1	17 interactors: AMPH AP1S1 AP2B1 APP ATM ATR BIN1 CLTC DNAJC6 DNM1 EPN1 EPS15 HTT NUMB SHC1 SMAD1 SNAP91
Entrez ID		163	161
HPRD ID		03015	06256
Ensembl ID		ENSG00000006125	ENSG00000183020
Uniprot IDs		K7EJT8 P63010 Q96EL6	O94973
PDB IDs		1E42 2G30 2IV8 2IV9 2JKR 2JKT 2VGL 2XA7
Enriched GO Terms of Interacting Partners?		Protein Localization Regulation Of Defense Response To Virus By Virus Endocytosis Viral Process Cellular Localization Protein Transport Regulation Of Defense Response To Virus Vesicle-mediated Transport Establishment Of Protein Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Establishment Of Localization In Cell Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Intracellular Transport Clathrin Coat Assembly Membrane Organization Receptor-mediated Endocytosis Cellular Protein Localization Organelle Organization Regulation Of Cellular Component Organization Mitotic Spindle Assembly Checkpoint Negative Regulation Of Chromosome Organization Post-Golgi Vesicle-mediated Transport Cellular Response To Growth Factor Stimulus Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Apoptotic Process Clathrin-mediated Endocytosis Response To Growth Factor Negative Regulation Of Chromosome Segregation Programmed Cell Death Cell Cycle Process Cell Differentiation Regulation Of Mitotic Sister Chromatid Separation Cell Development Cell Death Death Regulation Of Signaling Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Chromosome Organization Regulation Of Signal Transduction Cellular Protein Complex Assembly Pathway-restricted SMAD Protein Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Cellular Response To Organic Substance Negative Regulation Of Protein Catabolic Process Cell Activation Cell Cycle Mitotic Cell Cycle Process	Vesicle-mediated Transport Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Post-Golgi Vesicle-mediated Transport Golgi Vesicle Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Signaling Cell Communication Neuron Apoptotic Process Anatomical Structure Morphogenesis Neuron Death Transport Cell Aging Membrane Organization Replicative Senescence Enzyme Linked Receptor Protein Signaling Pathway Cell Differentiation Establishment Of Localization In Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Clathrin-mediated Endocytosis Regulation Of Signal Transduction Developmental Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Transport Generation Of Neurons Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Signal Transduction By P53 Class Mediator Multicellular Organismal Development Nervous System Development Regulation Of Receptor Activity Neurogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Cellular Response To Gamma Radiation Anatomical Structure Development Regulation Of Neurogenesis Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Cellular Localization Cell Morphogenesis Involved In Differentiation Learning Notch Signaling Pathway Cell Development Axon Guidance
Tagcloud ?		17q 17q12 aa552509 acly amplicon amplifications aoc3 copy custom est ests gains gastriccancer grb7 itga3 jup krt14 lhx1 mkp mln51 mln64 mprl45 pip5k2b q21 rpl27 tags top2a transcribed uncharacterized
Tagcloud (Difference) ?		17q 17q12 aa552509 acly amplicon amplifications aoc3 copy custom est ests gains gastriccancer grb7 itga3 jup krt14 lhx1 mkp mln51 mln64 mprl45 pip5k2b q21 rpl27 tags top2a transcribed uncharacterized
Tagcloud (Intersection) ?