AP2B1 and AP2S1

Number of citations of the paper that reports this interaction (PubMedID 12086608)
0

Data Source:
HPRD (in vitro)

		AP2B1	AP2S1
Description		adaptor related protein complex 2 subunit beta 1	adaptor related protein complex 2 subunit sigma 1
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GO Annotations	Cellular Component	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Endomembrane System Membrane Membrane Coat Clathrin Coat AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Synapse Clathrin-coated Endocytic Vesicle Postsynaptic Endocytic Zone Extrinsic Component Of Presynaptic Endocytic Zone Membrane Glutamatergic Synapse	Cytosol Plasma Membrane Clathrin-coated Pit Cytoplasmic Side Of Plasma Membrane Membrane Membrane Coat AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Endolysosome Membrane Intracellular Membrane-bounded Organelle Synapse Clathrin-coated Endocytic Vesicle Presynapse Postsynapse
	Molecular Function	Signal Sequence Binding Protein Binding Clathrin Binding Clathrin Adaptor Activity Protein-containing Complex Binding	Protein Binding Clathrin Adaptor Activity
	Biological Process	Kidney Development Cardiac Septum Development Ventricular Septum Development Intracellular Protein Transport Endocytosis Chemical Synaptic Transmission Neurotransmitter Secretion Heart Development Protein Transport Vesicle-mediated Transport Aorta Development Positive Regulation Of Endocytosis Clathrin Coat Assembly Synaptic Vesicle Endocytosis Coronary Vasculature Development Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Protein Localization To Membrane	Intracellular Protein Transport Endocytosis Protein Transport Vesicle-mediated Transport Regulation Of Endocytosis Clathrin Coat Assembly Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 22139419 27863252 32888494) Mean reticulocyte volume ( 32888494) Platelet count ( 22139419 27863252) Platelet distribution width ( 27863252) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Brain morphology (MOSTest) ( 32665545) Deep white matter hyperintensities ( 32517579) Low density lipoprotein cholesterol levels ( 32154731) Spondylosis ( 33332786)
Interacting Genes		60 interacting genes: - ACVR1 AFF4 AP1M1 AP1M2 AP2A2 AP2M1 AP2S1 APC ARF6 ARRB1 ATM ATP23 ATP6V1G1 BUB1 BUB1B CATSPERT CCDC187 CEBPA CLINT1 COL3A1 DHX58 DNAJC5 DSCAM FMNL2 GPANK1 GTF2I HIP1 HPCA HSPB1 KANK2 KIAA0408 KPNA2 LDLRAP1 LONRF1 MEA1 MLH1 NECAP2 NEU4 NUP54 PIP5K1C POM121 PSORS1C2 RAPGEF3 RIBC2 SLC25A6 SLC2A8 SMAD4 SMURF1 SNAP91 TENT5C TERF2IP TEX12 TGFBR1 TGFBR2 THAP1 TUBGCP4 TXN2 U2AF1 UBC	6 interacting genes: AAGAB AP2A1 AP2B1 CRIPTO RNF41 UBC
Entrez ID		163	1175
HPRD ID		03015	03762
Ensembl ID		ENSG00000006125	ENSG00000042753
Uniprot IDs		A0A140VJE8 P63010 Q96EL6	M0QYZ2 M0R0N4 P53680 X6R390
PDB IDs		1E42 2G30 2IV8 2IV9 2JKR 2JKT 2VGL 2XA7 4UQI 5M5R 6QH5 6QH6 6QH7 6URI 6YAE 6YAF 6YAH 6YAI 7OG1 7OHO 7OM8 7Z5C	6URI
Enriched GO Terms of Interacting Partners?		Clathrin Adaptor Activity SMAD Binding Clathrin Adaptor Complex Clathrin-dependent Endocytosis Clathrin-coated Pit Synaptic Vesicle Endocytosis Regulation Of Receptor-mediated Endocytosis Presynaptic Endocytosis Endocytosis Clathrin Coat Assembly Vesicle-mediated Transport In Synapse Activin Receptor Complex Activin Receptor Activity, Type I Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Activin Receptor Signaling Pathway Receptor-mediated Endocytosis Mitotic Spindle Assembly Checkpoint Signaling Intracellular Protein Transport Clathrin-coated Endocytic Vesicle Membrane Negative Regulation Of Mitotic Metaphase/anaphase Transition Activin Binding Endocytic Vesicle Membrane AP-2 Adaptor Complex Receptor Internalization Clathrin-coated Vesicle Membrane Clathrin Binding Protein Transport Transmembrane Receptor Protein Serine/threonine Kinase Activity Clathrin-coated Vesicle Negative Regulation Of Chromosome Organization Ventricular Septum Morphogenesis Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of SMAD Protein Signal Transduction Import Into Cell Regulation Of Endocytosis Vesicle-mediated Transport I-SMAD Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA-dependent Protein Kinase Activity Transforming Growth Factor Beta Ligand-receptor Complex Transforming Growth Factor Beta Receptor Signaling Pathway Endolysosome Membrane Positive Regulation Of Receptor-mediated Endocytosis Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Cellular Component Organization Establishment Of Protein Localization Positive Regulation Of Cellular Component Organization Intracellular Protein Localization	Endocytic Vesicle Membrane Postsynaptic Neurotransmitter Receptor Internalization Postsynaptic Endocytic Zone AP-2 Adaptor Complex Clathrin Adaptor Complex Clathrin Adaptor Activity Endolysosome Membrane Clathrin-coated Endocytic Vesicle Membrane Coat Clathrin-dependent Endocytosis Synaptic Vesicle Endocytosis Presynaptic Endocytosis Receptor Internalization Clathrin-coated Endocytic Vesicle Membrane Clathrin-coated Pit Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Vesicle-mediated Transport In Synapse Cytoplasmic Side Of Plasma Membrane Interleukin-3 Receptor Binding Synaptic Vesicle Nodal Binding Erythropoietin Receptor Binding Blood Vessel Development Positive Regulation Of Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process Signal Sequence Binding Receptor-mediated Endocytosis Extrinsic Component Of Presynaptic Endocytic Zone Membrane Clathrin Coat Activin Receptor Binding Clathrin Coat Of Trans-Golgi Network Vesicle Regulation Of Hyaluronan Biosynthetic Process Heart Development Anterior/posterior Axis Specification, Embryo Protein Transport Nodal Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Endocytosis Golgi To Endosome Transport Cellular Response To Hepatocyte Growth Factor Stimulus Protein Tag Activity Response To Hepatocyte Growth Factor Cellular Response To Interleukin-6 Filopodium Tip Protein-containing Complex Binding Apical Plasma Membrane Establishment Of Protein Localization Clathrin Coat Assembly Response To Interleukin-6 Endoplasmic Reticulum Tubular Network
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