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AP2B1 and DHX58
Number of citations of the paper that reports this interaction (PMID
16189514
)
699
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
AP2B1
DHX58
Gene Name
adaptor-related protein complex 2, beta 1 subunit
DEXH (Asp-Glu-X-His) box polypeptide 58
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Plasma Membrane
Membrane
AP-2 Adaptor Complex
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Intracellular Membrane-bounded Organelle
Cytoplasm
Molecular Function
Signal Sequence Binding
Protein Binding
Protein Transporter Activity
Clathrin Binding
Clathrin Adaptor Activity
DNA Binding
Double-stranded RNA Binding
Single-stranded RNA Binding
Helicase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Biological Process
Intracellular Protein Transport
Epidermal Growth Factor Receptor Signaling Pathway
Synaptic Transmission
Axon Guidance
Viral Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Regulation Of Defense Response To Virus By Virus
Clathrin-mediated Endocytosis
Metabolic Process
Response To Virus
Viral Process
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Negative Regulation Of MDA-5 Signaling Pathway
Negative Regulation Of RIG-I Signaling Pathway
Innate Immune Response
Regulation Of Innate Immune Response
Negative Regulation Of Innate Immune Response
Defense Response To Virus
Positive Regulation Of MDA-5 Signaling Pathway
Positive Regulation Of RIG-I Signaling Pathway
Pathways
Retrograde neurotrophin signalling
Axon guidance
HIV Infection
Nef Mediated CD8 Down-regulation
L1CAM interactions
Signaling by Wnt
Signaling by EGFRvIII in Cancer
Recycling pathway of L1
EPH-ephrin mediated repulsion of cells
MHC class II antigen presentation
EPH-Ephrin signaling
Nef Mediated CD4 Down-regulation
EGFR downregulation
Signalling by NGF
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
Host Interactions of HIV factors
The role of Nef in HIV-1 replication and disease pathogenesis
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
beta-catenin independent WNT signaling
Signaling by EGFR
WNT5A-dependent internalization of FZD4
Signaling by EGFR in Cancer
PCP/CE pathway
Adaptive Immune System
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Innate Immune System
Drugs
Diseases
GWAS
Mean platelet volume (
22139419
)
Platelet counts (
22139419
)
Protein-Protein Interactions
44 interactors:
ACVR1
AFF4
AP1M1
AP1M2
AP2A2
AP2M1
AP2S1
APC
ARRB1
ATM
ATP6V1G1
BUB1
BUB1B
CLINT1
CLTC
DHX58
FAM46C
GTF2I
HIP1
ITSN1
KIAA0408
KPNA2
LDLRAP1
MEA1
MLH1
NECAP2
NEU4
NUP54
PIP5K1C
POM121
RAPGEF3
RIBC2
SLC25A6
SMAD4
SMURF1
SNAP91
TERF2IP
TGFBR1
TGFBR2
THAP1
TUBGCP4
TXN2
U2AF1
XRCC6BP1
9 interactors:
AGO2
AP2B1
APP
DHX30
DICER1
EIF2AK2
EIF6
NKRF
STAU2
Entrez ID
163
79132
HPRD ID
03015
13115
Ensembl ID
ENSG00000006125
ENSG00000108771
Uniprot IDs
K7EJT8
P63010
Q96EL6
Q96C10
PDB IDs
1E42
2G30
2IV8
2IV9
2JKR
2JKT
2VGL
2XA7
2RQA
2W4R
3EQT
Enriched GO Terms of Interacting Partners
?
Protein Localization
Regulation Of Defense Response To Virus By Virus
Endocytosis
Viral Process
Cellular Localization
Protein Transport
Regulation Of Defense Response To Virus
Vesicle-mediated Transport
Establishment Of Protein Localization
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Establishment Of Localization In Cell
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Intracellular Transport
Clathrin Coat Assembly
Membrane Organization
Receptor-mediated Endocytosis
Cellular Protein Localization
Organelle Organization
Regulation Of Cellular Component Organization
Mitotic Spindle Assembly Checkpoint
Negative Regulation Of Chromosome Organization
Post-Golgi Vesicle-mediated Transport
Cellular Response To Growth Factor Stimulus
Spindle Assembly Checkpoint
Mitotic Spindle Checkpoint
Apoptotic Process
Clathrin-mediated Endocytosis
Response To Growth Factor
Negative Regulation Of Chromosome Segregation
Programmed Cell Death
Cell Cycle Process
Cell Differentiation
Regulation Of Mitotic Sister Chromatid Separation
Cell Development
Cell Death
Death
Regulation Of Signaling
Negative Regulation Of Mitotic Nuclear Division
Spindle Checkpoint
Regulation Of Chromosome Organization
Regulation Of Signal Transduction
Cellular Protein Complex Assembly
Pathway-restricted SMAD Protein Phosphorylation
Regulation Of Mitotic Metaphase/anaphase Transition
Cellular Response To Organic Substance
Negative Regulation Of Protein Catabolic Process
Cell Activation
Cell Cycle
Mitotic Cell Cycle Process
RNA Interference
Pre-miRNA Processing
Posttranscriptional Regulation Of Gene Expression
Production Of MiRNAs Involved In Gene Silencing By MiRNA
Ribonucleoprotein Complex Assembly
Regulation Of Defense Response To Virus By Virus
RNA Processing
Gene Expression
Gene Silencing By MiRNA
Cellular Response To DsRNA
Posttranscriptional Gene Silencing
Regulation Of Translation
Ribonucleoprotein Complex Biogenesis
Gene Silencing By RNA
Regulation Of Viral Genome Replication
RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Regulation Of Translational Initiation
Response To DsRNA
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
RNA Metabolic Process
Evasion Or Tolerance By Virus Of Host Immune Response
Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference
Hair Follicle Cell Proliferation
Conversion Of Ds SiRNA To Ss SiRNA
Regulation Of ERBB Signaling Pathway
Regulation Of Defense Response To Virus
Negative Regulation Of Translation
Negative Regulation Of Cellular Metabolic Process
Immune System Process
Gene Silencing
RNA Phosphodiester Bond Hydrolysis
MRNA Cleavage Involved In Gene Silencing By MiRNA
Regulation Of Enamel Mineralization
Peripheral Nervous System Myelin Formation
Synaptic Growth At Neuromuscular Junction
Zygote Asymmetric Cell Division
Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Gene Expression
Defense Response
Negative Regulation Of Biosynthetic Process
SiRNA Loading Onto RISC Involved In RNA Interference
Targeting Of MRNA For Destruction Involved In RNA Interference
Collateral Sprouting In Absence Of Injury
Evasion Or Tolerance Of Host Defenses By Virus
Notch Signaling Pathway
Post-embryonic Development
Cellular Macromolecular Complex Assembly
Regulation Of Viral Process
Neuron Projection Morphogenesis
Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation
Tagcloud
?
17q
17q12
aa552509
acly
amplicon
amplifications
aoc3
copy
custom
est
ests
gains
gastriccancer
grb7
itga3
jup
krt14
lhx1
mkp
mln51
mln64
mprl45
pip5k2b
q21
rpl27
tags
top2a
transcribed
uncharacterized
Tagcloud (Difference)
?
17q
17q12
aa552509
acly
amplicon
amplifications
aoc3
copy
custom
est
ests
gains
gastriccancer
grb7
itga3
jup
krt14
lhx1
mkp
mln51
mln64
mprl45
pip5k2b
q21
rpl27
tags
top2a
transcribed
uncharacterized
Tagcloud (Intersection)
?