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AP2B1 and NECAP2
Number of citations of the paper that reports this interaction (PubMedID
35271311
)
106
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(two hybrid)
AP2B1
NECAP2
Description
adaptor related protein complex 2 subunit beta 1
NECAP endocytosis associated 2
Image
No pdb structure
GO Annotations
Cellular Component
Lysosomal Membrane
Cytosol
Plasma Membrane
Clathrin-coated Pit
Synaptic Vesicle
Cytoplasmic Side Of Plasma Membrane
Endomembrane System
Membrane
Membrane Coat
Clathrin Coat
AP-2 Adaptor Complex
Clathrin Adaptor Complex
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Cytoplasmic Vesicle
Endolysosome Membrane
Synapse
Clathrin-coated Endocytic Vesicle
Postsynaptic Endocytic Zone
Extrinsic Component Of Presynaptic Endocytic Zone Membrane
Glutamatergic Synapse
Plasma Membrane
Clathrin-coated Pit
Membrane
Clathrin Vesicle Coat
Clathrin-coated Vesicle Membrane
Cytoplasmic Vesicle
Molecular Function
Signal Sequence Binding
Protein Binding
Clathrin Binding
Clathrin Adaptor Activity
Protein-containing Complex Binding
Protein Binding
Biological Process
Kidney Development
Cardiac Septum Development
Ventricular Septum Development
Intracellular Protein Transport
Endocytosis
Chemical Synaptic Transmission
Neurotransmitter Secretion
Heart Development
Protein Transport
Vesicle-mediated Transport
Aorta Development
Positive Regulation Of Endocytosis
Clathrin Coat Assembly
Synaptic Vesicle Endocytosis
Coronary Vasculature Development
Clathrin-dependent Endocytosis
Postsynaptic Neurotransmitter Receptor Internalization
Positive Regulation Of Protein Localization To Membrane
Endocytosis
Protein Transport
Vesicle-mediated Transport
Pathways
Nef Mediated CD4 Down-regulation
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
Nef Mediated CD8 Down-regulation
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Recycling pathway of L1
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance
Potential therapeutics for SARS
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Drugs
Diseases
GWAS
Cerebrospinal AB1-42 levels in normal cognition (
29274321
)
Chronotype (
30696823
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
27863252
32888494
)
Immature fraction of reticulocytes (
32888494
)
Mean platelet volume (
22139419
27863252
32888494
)
Mean reticulocyte volume (
32888494
)
Platelet count (
22139419
27863252
)
Platelet distribution width (
27863252
)
Reticulocyte count (
27863252
32888494
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Interacting Genes
60 interacting genes:
-
ACVR1
AFF4
AP1M1
AP1M2
AP2A2
AP2M1
AP2S1
APC
ARF6
ARRB1
ATM
ATP23
ATP6V1G1
BUB1
BUB1B
CATSPERT
CCDC187
CEBPA
CLINT1
COL3A1
DHX58
DNAJC5
DSCAM
FMNL2
GPANK1
GTF2I
HIP1
HPCA
HSPB1
KANK2
KIAA0408
KPNA2
LDLRAP1
LONRF1
MEA1
MLH1
NECAP2
NEU4
NUP54
PIP5K1C
POM121
PSORS1C2
RAPGEF3
RIBC2
SLC25A6
SLC2A8
SMAD4
SMURF1
SNAP91
TENT5C
TERF2IP
TEX12
TGFBR1
TGFBR2
THAP1
TUBGCP4
TXN2
U2AF1
UBC
6 interacting genes:
AP2B1
APP
NMI
PLSCR1
SNCA
TRAF2
Entrez ID
163
55707
HPRD ID
03015
07674
Ensembl ID
ENSG00000006125
ENSG00000157191
Uniprot IDs
A0A140VJE8
P63010
Q96EL6
F6SKB8
Q9NVZ3
PDB IDs
1E42
2G30
2IV8
2IV9
2JKR
2JKT
2VGL
2XA7
4UQI
5M5R
6QH5
6QH6
6QH7
6URI
6YAE
6YAF
6YAH
6YAI
7OG1
7OHO
7OM8
7Z5C
Enriched GO Terms of Interacting Partners
?
Clathrin Adaptor Activity
SMAD Binding
Clathrin Adaptor Complex
Clathrin-dependent Endocytosis
Clathrin-coated Pit
Synaptic Vesicle Endocytosis
Regulation Of Receptor-mediated Endocytosis
Presynaptic Endocytosis
Endocytosis
Clathrin Coat Assembly
Vesicle-mediated Transport In Synapse
Activin Receptor Complex
Activin Receptor Activity, Type I
Postsynaptic Neurotransmitter Receptor Internalization
Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition
Activin Receptor Signaling Pathway
Receptor-mediated Endocytosis
Mitotic Spindle Assembly Checkpoint Signaling
Intracellular Protein Transport
Clathrin-coated Endocytic Vesicle Membrane
Negative Regulation Of Mitotic Metaphase/anaphase Transition
Activin Binding
Endocytic Vesicle Membrane
AP-2 Adaptor Complex
Receptor Internalization
Clathrin-coated Vesicle Membrane
Clathrin Binding
Protein Transport
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Clathrin-coated Vesicle
Negative Regulation Of Chromosome Organization
Ventricular Septum Morphogenesis
Negative Regulation Of Mitotic Nuclear Division
Positive Regulation Of SMAD Protein Signal Transduction
Import Into Cell
Regulation Of Endocytosis
Vesicle-mediated Transport
I-SMAD Binding
Negative Regulation Of Mitotic Cell Cycle Phase Transition
DNA-dependent Protein Kinase Activity
Transforming Growth Factor Beta Ligand-receptor Complex
Transforming Growth Factor Beta Receptor Signaling Pathway
Endolysosome Membrane
Positive Regulation Of Receptor-mediated Endocytosis
Transforming Growth Factor Beta Binding
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Negative Regulation Of Cellular Component Organization
Establishment Of Protein Localization
Positive Regulation Of Cellular Component Organization
Intracellular Protein Localization
Cell Activation
Macrophage Activation
Regulation Of Endocytosis
Enzyme Binding
Positive Regulation Of Endocytosis
Regulation Of Vesicle-mediated Transport
Response To Lead Ion
Positive Regulation Of Inflammatory Response
Response To External Biotic Stimulus
Positive Regulation Of Defense Response
Myeloid Leukocyte Activation
Regulation Of Neurotransmitter Uptake
Leukocyte Activation
Cellular Response To Copper Ion
Membrane Raft
Regulation Of Presynapse Organization
Regulation Of Immune System Process
Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Presynapse Assembly
Amyloid Fibril Formation
Microglial Cell Activation
Leukocyte Activation Involved In Inflammatory Response
Response To Copper Ion
Synaptic Vesicle Endocytosis
Regulation Of Defense Response
Neurotransmitter Secretion
Presynaptic Endocytosis
Apoptotic Process
Chemical Synaptic Transmission
Positive Regulation Of Phosphate Metabolic Process
Programmed Cell Death
Cell Death
Regulation Of Immune Response
Response To Metal Ion
Trans-synaptic Signaling
Synaptic Signaling
Positive Regulation Of Immune System Process
Regulation Of Neuronal Synaptic Plasticity
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Response To Other Organism
Regulation Of Cellular Component Organization
Receptor Internalization
Endocytosis
Clathrin-coated Pit
Positive Regulation Of Protein Localization
Amyloid-beta Complex
Response To Interleukin-1
Growth Cone Lamellipodium
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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