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KLHL35 and ALAS1
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
KLHL35
ALAS1
Description
kelch like family member 35
5'-aminolevulinate synthase 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cul3-RING Ubiquitin Ligase Complex
Nucleoplasm
Mitochondrion
Mitochondrial Inner Membrane
Mitochondrial Matrix
Cytosol
Membrane
Molecular Function
Protein Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
5-aminolevulinate Synthase Activity
Protein Binding
Transferase Activity
Acyltransferase Activity
Pyridoxal Phosphate Binding
Identical Protein Binding
Biological Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Response To Hypoxia
Porphyrin-containing Compound Metabolic Process
Protoporphyrinogen IX Biosynthetic Process
Heme Biosynthetic Process
Heme A Biosynthetic Process
Heme B Biosynthetic Process
Response To Xenobiotic Stimulus
Response To Herbicide
Response To Nickel Cation
Response To Nutrient Levels
Response To Cobalt Ion
Cellular Response To Insulin Stimulus
Tetrapyrrole Biosynthetic Process
Response To Gonadotropin
Hemoglobin Biosynthetic Process
Response To Ethanol
Heme O Biosynthetic Process
Erythrocyte Development
Response To CAMP
Response To Platinum Ion
Response To Bile Acid
Pathways
Heme biosynthesis
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Mitochondrial protein degradation
Drugs
Pyridoxal phosphate
Pyridoxal phosphate
Glycine
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
21926972
)
Parkinson's disease (
28892059
)
Schizophrenia (
23974872
)
Interacting Genes
12 interacting genes:
ACVR1
ALAS1
APPBP2
CALCOCO2
FAM25A
FAM25C
FAM25G
GOLGA6L9
MX1
NCK2
TGFBR1
UBTD2
54 interacting genes:
BCL7A
C2orf42
C8orf33
CAP2
CCHCR1
CDC73
CDK5
CDKN1A
CERK
COBL
EP400
FBXL8
FXR1
GNL3L
GRXCR1
HSBP1L1
JRK
KIF9
KLHL35
LONRF1
LRRC45
MTFR2
MTSS2
NUDT3
OXTR
PIBF1
PIK3CB
PLAU
POLDIP2
PPL
RAP1B
RNF168
RTL8B
SH2D4A
SNRPB2
SNX20
STAMBP
SUMO2
TCEA2
TEKT4
TK1
TMSB10
TMSB4X
TMSB4XP1
TMSB4XP2
TMSB4XP6
TTC23
USP20
UTP14C
WIPF1
ZFYVE26
ZMAT1
ZNF175
ZNF564
Entrez ID
283212
211
HPRD ID
08747
00505
Ensembl ID
ENSG00000149243
ENSG00000023330
Uniprot IDs
Q6PF15
B4DVA0
P13196
Q5JAM2
PDB IDs
Enriched GO Terms of Interacting Partners
?
Activin Receptor Complex
Activin Receptor Activity, Type I
Transforming Growth Factor Beta Receptor Activity, Type I
Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Activin Binding
Pharyngeal System Development
Transforming Growth Factor Beta Binding
Activin Receptor Signaling Pathway
Ventricular Septum Morphogenesis
Positive Regulation Of SMAD Protein Signal Transduction
Growth Factor Binding
SMAD Binding
Endocardial Cushion Cell Fate Commitment
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of SMAD Protein Signal Transduction
Cardiac Septum Morphogenesis
Positive Regulation Of Determination Of Dorsal Identity
5-aminolevulinate Synthase Activity
Response To Nickel Cation
Vascular Endothelial Cell Proliferation
Epicardium Morphogenesis
Actin Monomer Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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