ZZZ3 and EPS8

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ZZZ3	EPS8
Gene Name		zinc finger, ZZ-type containing 3	epidermal growth factor receptor pathway substrate 8
Image
Gene Ontology Annotations	Cellular Component	Nucleus Ada2/Gcn5/Ada3 Transcription Activator Complex Nucleolus Nuclear Membrane	Cell Cortex Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Growth Cone Vesicle Stereocilium Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding	Actin Binding SH3/SH2 Adaptor Activity Protein Binding Rac GTPase Binding
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Adult Locomotory Behavior Regulation Of Cell Shape Positive Regulation Of Signal Transduction Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Actin Cytoskeleton Reorganization Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS		Obesity ( 23563607)	Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		16 interactors: BLZF1 DNAJB11 EPS8 FAM124A GATA1 HOXA1 IKBKG LZTR1 MAML3 PBXIP1 PCBD2 TRIM22 ZBTB9 ZNF212 ZNF496 ZNF513	54 interactors: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BYSL C17orf59 C19orf25 C8orf33 CASK CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RFXAP RUNX1T1 SCRN3 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XRCC6 ZZZ3
Entrez ID		26009	2059
HPRD ID		15907	02563
Ensembl ID		ENSG00000036549	ENSG00000151491
Uniprot IDs		Q8IYH5	B4DX66 B4E3T6 Q12929
PDB IDs		2FC7 2YUM	2E8M
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Optokinetic Behavior Abducens Nerve Formation Facial Nucleus Development Basophil Differentiation Eosinophil Fate Commitment Eosinophil Differentiation Rhombomere 4 Development Actin Polymerization-dependent Cell Motility Semicircular Canal Formation Transcriptional Activation By Promoter-enhancer Looping Rhombomere 3 Development Rhombomere 5 Development Positive Regulation Of Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Definitive Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Exit From Mitosis Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryonic Neurocranium Morphogenesis Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Behavioral Response To Ethanol Outer Ear Morphogenesis	Cell Differentiation Developmental Process Movement Of Cell Or Subcellular Component Multicellular Organismal Development System Development Anatomical Structure Development Cell Projection Morphogenesis Cell Part Morphogenesis Axonogenesis Axon Guidance Fc Receptor Signaling Pathway Axon Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Morphogenesis Chemotaxis Neurogenesis Neuron Projection Development Immune Response-regulating Signaling Pathway Neuron Projection Morphogenesis Organelle Organization Positive Regulation Of Signal Transduction Cell Morphogenesis Leukocyte Migration Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Generation Of Neurons Cell Development Response To External Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Development Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Hemostasis Regulation Of ERBB Signaling Pathway Nervous System Development Innate Immune Response Anatomical Structure Formation Involved In Morphogenesis Regulation Of Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Phosphorylation Regulation Of Immune System Process Platelet Activation Response To Fibroblast Growth Factor
Tagcloud ?		5th adcy9 ancestry broader classes etiological exploiting extremes generalizable gnat2 h6pd height hip hnf4g hs6st3 igfbp4 influencing loci mrps33p4 obesity overlap percentiles ppp2r2a rptor rsrc1 tails trait traits waist	adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound
Tagcloud (Difference) ?		5th adcy9 ancestry broader classes etiological exploiting extremes generalizable gnat2 h6pd height hip hnf4g hs6st3 igfbp4 influencing loci mrps33p4 obesity overlap percentiles ppp2r2a rptor rsrc1 tails trait traits waist	adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound
Tagcloud (Intersection) ?