ZZZ3 and MAML3

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ZZZ3	MAML3
Gene Name		zinc finger, ZZ-type containing 3	mastermind-like 3 (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Ada2/Gcn5/Ada3 Transcription Activator Complex Nucleolus Nuclear Membrane	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding	Transcription Coactivator Activity
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 intracellular domain regulates transcription Notch-HLH transcription pathway Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH2 Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Obesity ( 23563607)	Congenital heart malformation ( 23708190)
Protein-Protein Interactions		16 interactors: BLZF1 DNAJB11 EPS8 FAM124A GATA1 HOXA1 IKBKG LZTR1 MAML3 PBXIP1 PCBD2 TRIM22 ZBTB9 ZNF212 ZNF496 ZNF513	10 interactors: NFX1 NOTCH1 NOTCH2 NOTCH3 NOTCH4 RAI1 SCMH1 SUPT5H ZBTB1 ZZZ3
Entrez ID		26009	55534
HPRD ID		15907	10066
Ensembl ID		ENSG00000036549	ENSG00000196782
Uniprot IDs		Q8IYH5	Q96JK9 Q9NPV6
PDB IDs		2FC7 2YUM
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Optokinetic Behavior Abducens Nerve Formation Facial Nucleus Development Basophil Differentiation Eosinophil Fate Commitment Eosinophil Differentiation Rhombomere 4 Development Actin Polymerization-dependent Cell Motility Semicircular Canal Formation Transcriptional Activation By Promoter-enhancer Looping Rhombomere 3 Development Rhombomere 5 Development Positive Regulation Of Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Definitive Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Exit From Mitosis Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryonic Neurocranium Morphogenesis Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Behavioral Response To Ethanol Outer Ear Morphogenesis	Notch Receptor Processing Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Notch Signaling Pathway Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cell Fate Commitment Interleukin-4 Secretion Notch Signaling Involved In Heart Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Pulmonary Valve Morphogenesis Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Interleukin-4 Production Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Pattern Specification Process Regulation Of Endothelial Cell Differentiation Glomerulus Vasculature Development Blood Vessel Development Vasculature Development Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Cellular Metabolic Process Cardiac Atrium Morphogenesis Inflammatory Response To Antigenic Stimulus Cytokine Secretion Heart Valve Morphogenesis Heart Valve Development Positive Regulation Of BMP Signaling Pathway
Tagcloud ?		5th adcy9 ancestry broader classes etiological exploiting extremes generalizable gnat2 h6pd height hip hnf4g hs6st3 igfbp4 influencing loci mrps33p4 obesity overlap percentiles ppp2r2a rptor rsrc1 tails trait traits waist	2c acetyltransferase activators binds box broadly catenin cdk8 coactivator coactivators connects conserved contains diverse enhancer evolutionarily interact key mads maml1 maml2 mastermind mediator mef molecule notch regulate suppressor
Tagcloud (Difference) ?		5th adcy9 ancestry broader classes etiological exploiting extremes generalizable gnat2 h6pd height hip hnf4g hs6st3 igfbp4 influencing loci mrps33p4 obesity overlap percentiles ppp2r2a rptor rsrc1 tails trait traits waist	2c acetyltransferase activators binds box broadly catenin cdk8 coactivator coactivators connects conserved contains diverse enhancer evolutionarily interact key mads maml1 maml2 mastermind mediator mef molecule notch regulate suppressor
Tagcloud (Intersection) ?