ZZZ3 and TRIM22

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		ZZZ3	TRIM22
Description		zinc finger ZZ-type containing 3	tripartite motif containing 22
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Mitotic Spindle ATAC Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cajal Body Nuclear Body Nuclear Speck
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Regulation Of Cell Division Regulation Of Cell Cycle	Positive Regulation Of Defense Response To Virus By Host Regulation Of DNA-templated Transcription Immune Response Response To Virus Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Defense Response To Virus Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process Antiviral Innate Immune Response
Pathways		HATs acetylate histones Formation of WDR5-containing histone-modifying complexes	Interferon gamma signaling
Drugs
Diseases
GWAS		A body shape index ( 34021172) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Height ( 31562340) Hip circumference ( 25673412) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Obesity ( 23563607) Platelet count ( 32888494) Type 2 diabetes (age of onset) ( 28060188) Waist-to-hip ratio adjusted for BMI ( 34021172)	Coronary artery disease ( 29212778) Malaria ( 31844061)
Interacting Genes		21 interacting genes: BLZF1 CARD9 DNAJB11 EFHC2 EPS8 FAM124A GATA1 GOLGA2 IKBKG LZTR1 MAML3 PBXIP1 PCBD2 PICK1 PPP1R13B TRAF2 TRIM22 ZBTB9 ZNF212 ZNF496 ZNF513	13 interacting genes: CASK CIC CREB1 LGALS3 LGALS8 MFHAS1 PLEKHF2 RAF1 RERE TAF7 UBE2D1 USP7 ZZZ3
Entrez ID		26009	10346
HPRD ID		15907	05951
Ensembl ID		ENSG00000036549	ENSG00000132274
Uniprot IDs		Q8IYH5	B4DQS5 Q8IYM9
PDB IDs		2FC7 2YUM 6E83 6E86
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding	Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Histone Acetyltransferase Binding Positive Regulation Of Calcium Ion Import Cerebellar Purkinje Cell Layer Maturation Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Radial Glia Guided Migration Of Purkinje Cell Response To Dehydroepiandrosterone Positive Regulation Of Cardiac Muscle Tissue Development ATF4-CREB1 Transcription Factor Complex Hormone Transport Regulation Of DNA-templated Transcription Initiation Intracellular Signal Transduction Positive Regulation Of Transforming Growth Factor Beta3 Production Hormone Secretion Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription By RNA Polymerase II Response To Hypobaric Hypoxia MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription Initiation By RNA Polymerase II MRNA Transcription Chemotaxis To Arachidonate Transcription By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of NK T Cell Activation Negative Regulation Of Signal Transduction Disaccharide Binding Negative Regulation Of Immunological Synapse Formation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Calcium Ion Import Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Calcium Ion Transport Lymphatic Endothelial Cell Migration Death-inducing Signaling Complex Assembly Negative Regulation Of MHC Class I Biosynthetic Process TFIIH-class Transcription Factor Complex Binding Spermine Transport P-TEFb Complex Binding Negative Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling
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