TXNIP and TXN

Number of citations of the paper that reports this interaction (PMID 10419473)
100

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		TXNIP	TXN
Gene Name		thioredoxin interacting protein	thioredoxin
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Intermembrane Space Cytosol	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Vesicular Exosome
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding Protein Disulfide Oxidoreductase Activity Peptide Disulfide Oxidoreductase Activity Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Protein Import Into Nucleus Cell Cycle Response To Mechanical Stimulus Response To Glucose Keratinocyte Differentiation Response To Estradiol Response To Progesterone Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Cell Proliferation Response To Drug Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Innate Immune Response Platelet-derived Growth Factor Receptor Signaling Pathway Response To Calcium Ion Negative Regulation Of Cell Division Cellular Response To Tumor Cell	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Reactive Oxygen Species Transcription, DNA-templated Glycerol Ether Metabolic Process Movement Of Cell Or Subcellular Component Signal Transduction Cell-cell Signaling Cell Proliferation Response To Radiation Nucleobase-containing Small Molecule Interconversion Activation Of Protein Kinase B Activity Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Protein Import Into Nucleus, Translocation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of DNA Binding Small Molecule Metabolic Process Innate Immune Response Cell Redox Homeostasis Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Kinase B Signaling Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Pathways		The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System	The NLRP3 inflammasome Inflammasomes Oxidative Stress Induced Senescence Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Cellular Senescence Detoxification of Reactive Oxygen Species Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: DDIT4 ECD FHL1 HDAC1 HDAC3 ITCH KPNA2 PRKAA1 SCEL SMURF2 TXN TXNRD1 ZBTB16 ZBTB32	22 interactors: ACTN4 APEX1 CDKN1A COL1A1 COPS5 DNAJA1 DYNLT1 FST GFER GPRASP2 MAP3K5 MLH1 MYD88 NCF4 NFE2 NFKB1 NR3C1 SIAH1 TP53 TXNIP UCHL5 VIM
Entrez ID		10628	7295
HPRD ID		05964	01761
Ensembl ID		ENSG00000117289	ENSG00000136810
Uniprot IDs		Q9H3M7	H9ZYJ2 P10599
PDB IDs		4GEI 4GEJ	1AIU 1AUC 1CQG 1CQH 1ERT 1ERU 1ERV 1ERW 1M7T 1MDI 1MDJ 1MDK 1TRS 1TRU 1TRV 1TRW 1W1C 1W1E 2HSH 2HXK 2IFQ 2IIY 3E3E 3KD0 3M9J 3M9K 3QFA 3QFB 3TRX 4TRX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Regulation Of Glycolytic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Regulation Of TOR Signaling Regulation Of Nitrogen Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Death Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Nucleobase-containing Compound Metabolic Process Nucleobase-containing Small Molecule Interconversion Cell Proliferation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Notch Signaling Pathway Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Carbohydrate Metabolic Process Histone H4 Deacetylation Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle RNA Metabolic Process Negative Regulation Of JNK Cascade Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Death Nitrogen Compound Metabolic Process Negative Regulation Of TOR Signaling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Reactive Oxygen Species Histone H3 Deacetylation Negative Regulation Of Stress-activated MAPK Cascade Histone H3-K9 Modification Regulation Of RNA Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Response To Stress Gene Expression Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor	Regulation Of Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Signal Transduction Cell Communication Response To Stress Response To Oxidative Stress Response To Stimulus Regulation Of Signaling Response To Abiotic Stimulus Response To Hydrogen Peroxide Signaling Immune System Process Cellular Response To Stimulus Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Immune Response Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Response To Growth Factor Regulation Of Cellular Process Apoptotic Process Regulation Of JNK Cascade Signal Transduction Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Response To Organic Substance Cell Death Regulation Of Stress-activated MAPK Cascade Death Response To Reactive Oxygen Species Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress Developmental Process Epithelium Development Intracellular Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Neuron Death Response To Mechanical Stimulus Cellular Response To Mechanical Stimulus Stress-induced Premature Senescence Anatomical Structure Development Negative Regulation Of Catalytic Activity Response To Inorganic Substance System Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Tagcloud ?		another arrest better br breast bt474 causes corresponding g1 indicated inversely little marker microarray noncancerous os p27 plays previous prognostic r regarding sk strong taken thioredoxin tissue transfection validated	alphascreen ammp calnexin cndp2 combines hsp90aa1 hsp90b1 hspa1b hspa5 hspa9 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 ubc unraveling vcp
Tagcloud (Difference) ?		another arrest better br breast bt474 causes corresponding g1 indicated inversely little marker microarray noncancerous os p27 plays previous prognostic r regarding sk strong taken thioredoxin tissue transfection validated	alphascreen ammp calnexin cndp2 combines hsp90aa1 hsp90b1 hspa1b hspa5 hspa9 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 ubc unraveling vcp
Tagcloud (Intersection) ?