TXNIP and LUC7L3

Number of citations of the paper that reports this interaction (PubMedID 31669268)
0

Data Source:
BioGRID (two hybrid)

		TXNIP	LUC7L3
Description		thioredoxin interacting protein	LUC7 like 3 pre-mRNA splicing factor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm U1 SnRNP Nuclear Speck U2-type Prespliceosome
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding	DNA Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Inflammatory Response Response To Oxidative Stress Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Glucose Protein Transport Keratinocyte Differentiation Response To Estradiol Response To Progesterone Regulation Of Cell Population Proliferation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Response To Calcium Ion Negative Regulation Of Cell Division Cellular Response To Tumor Cell Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus	MRNA Splice Site Recognition MRNA Processing RNA Splicing
Pathways		The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection Cytoprotection by HMOX1	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Femur bone mineral density x serum urate levels interaction ( 34046847) Mild to moderate chronic kidney disease ( 31178898)
Interacting Genes		30 interacting genes: CBX8 DDIT4 ECD EEF1A1 FHL1 GAPDH HDAC1 HDAC3 HSPB2 IDI1 INTS9 KPNA2 LUC7L3 MAPK1 NLGN3 PRKAA1 PTPN11 RUVBL2 SCEL SIVA1 SLC2A1 SMURF2 TRAF6 TXN TXNRD1 UBR5 UXT WWP1 ZBTB16 ZBTB32	12 interacting genes: CLK1 ITSN2 MLH1 OGT RNPS1 SRPK1 SRPK2 SRSF1 TLR10 TXNIP USP7 YWHAG
Entrez ID		10628	51747
HPRD ID		05964	16759
Ensembl ID		ENSG00000265972	ENSG00000108848
Uniprot IDs		Q9H3M7	A8K3C5 J3KPP4 O95232 Q86Y74
PDB IDs		4GEI 4GEJ 4GFX 4LL1 4LL4 4ROF 4ROJ 5CQ2 5DF6 5DWS 5DZD
Enriched GO Terms of Interacting Partners?		Nucleus Cytosol Cytoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Protein Lysine Delactylase Activity Regulation Of Signal Transduction Positive Regulation Of Type I Interferon Production Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Nucleoplasm Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Export From Nucleus Regulation Of Protein Stability Regulation Of Gene Expression Positive Regulation Of Signal Transduction Protein Modification Process Regulation Of Cell Communication Regulation Of Macromolecule Biosynthetic Process Regulation Of Signaling Regulation Of RNA Metabolic Process Regulation Of Nucleocytoplasmic Transport Thioredoxin-disulfide Reductase (NADPH) Activity Regulation Of Canonical Wnt Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Type I Interferon Production Histone Deacetylase Binding Negative Regulation Of Protein Export From Nucleus Transcription Corepressor Binding Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Transport Response To Epidermal Growth Factor Regulation Of Intracellular Protein Transport Histone Deacetylase Activity, Hydrolytic Mechanism Bergmann Glial Cell Differentiation	Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing TORC1 Signaling TOR Signaling MRNA Metabolic Process Regulation Of TORC1 Signaling Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Exon-exon Junction Complex RNA Splicing Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of TOR Signaling Nuclear Speck MRNA Processing Positive Regulation Of Viral Genome Replication Response To Stress Protein-RNA Complex Assembly Regulation Of Macromolecule Metabolic Process Signal Transduction Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Negative Regulation Of Gene Expression Cellular Response To Nutrient Levels Regulation Of Gluconeogenesis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein Localization To Organelle Protein Localization To Lysosome Regulation Of Metabolic Process Positive Regulation Of Viral Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Gene Expression Chromosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment
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