TXNIP and FHL1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TXNIP	FHL1
Gene Name		thioredoxin interacting protein	four and a half LIM domains 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Intermembrane Space Cytosol	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding	Molecular_function Protein Binding Zinc Ion Binding Ion Channel Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Protein Import Into Nucleus Cell Cycle Response To Mechanical Stimulus Response To Glucose Keratinocyte Differentiation Response To Estradiol Response To Progesterone Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Cell Proliferation Response To Drug Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Innate Immune Response Platelet-derived Growth Factor Receptor Signaling Pathway Response To Calcium Ion Negative Regulation Of Cell Division Cellular Response To Tumor Cell	Regulation Of Membrane Depolarization Muscle Organ Development Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: DDIT4 ECD FHL1 HDAC1 HDAC3 ITCH KPNA2 PRKAA1 SCEL SMURF2 TXN TXNRD1 ZBTB16 ZBTB32	19 interactors: AKAP12 CBX4 DBN1 DEAF1 EED FHL2 HES1 HIVEP3 MYBPC1 PDE4DIP PRNP RBPJ RING1 SRF SRPK1 TTN TXNIP UBE2E2 USP15
Entrez ID		10628	2273
HPRD ID		05964	02157
Ensembl ID		ENSG00000117289	ENSG00000022267
Uniprot IDs		Q9H3M7	B7Z9A1 Q13642
PDB IDs		4GEI 4GEJ	1X63 2CUP 2CUR 2EGQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Regulation Of Glycolytic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Regulation Of TOR Signaling Regulation Of Nitrogen Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Death Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Nucleobase-containing Compound Metabolic Process Nucleobase-containing Small Molecule Interconversion Cell Proliferation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Notch Signaling Pathway Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Carbohydrate Metabolic Process Histone H4 Deacetylation Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle RNA Metabolic Process Negative Regulation Of JNK Cascade Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Death Nitrogen Compound Metabolic Process Negative Regulation Of TOR Signaling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Reactive Oxygen Species Histone H3 Deacetylation Negative Regulation Of Stress-activated MAPK Cascade Histone H3-K9 Modification Regulation Of RNA Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Response To Stress Gene Expression Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor	Cardiocyte Differentiation Heart Morphogenesis Aorta Morphogenesis Negative Regulation Of Transcription, DNA-templated Heart Trabecula Morphogenesis Aorta Development Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Muscle Structure Development Transcription, DNA-templated Regulation Of RNA Metabolic Process Striated Muscle Tissue Development Negative Regulation Of Gene Expression RNA Biosynthetic Process Muscle Cell Differentiation Cardiac Chamber Development Negative Regulation Of Biosynthetic Process Muscle Tissue Development Trabecula Morphogenesis RNA Metabolic Process Auditory Receptor Cell Fate Commitment Dorsal Aorta Morphogenesis Regulation Of Gene Expression Muscle Cell Development Artery Morphogenesis Dorsal Aorta Development Cell Differentiation Negative Regulation Of Cellular Metabolic Process Cardiac Muscle Tissue Development Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Regulation Of Transcription, DNA-templated Artery Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cardiac Muscle Cell Development Tissue Development Regulation Of Metabolic Process Cardiac Muscle Cell Myoblast Differentiation Nucleobase-containing Compound Metabolic Process Cell Development Heart Development Regulation Of Transcription From RNA Polymerase II Promoter Cardioblast Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Anatomical Structure Development Heart Trabecula Formation Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		another arrest better br breast bt474 causes corresponding g1 indicated inversely little marker microarray noncancerous os p27 plays previous prognostic r regarding sk strong taken thioredoxin tissue transfection validated	764g atrophy biopsy bodies boy cardiomyopathy distal dreifuss dystrophy echocardiogram emery exon hemizygous hypertrophic linked missense muscle muscular myopathy occurring pathology postural predominantly reducing scapuloperoneal sequencing vacuolar wasting weakness
Tagcloud (Difference) ?		another arrest better br breast bt474 causes corresponding g1 indicated inversely little marker microarray noncancerous os p27 plays previous prognostic r regarding sk strong taken thioredoxin tissue transfection validated	764g atrophy biopsy bodies boy cardiomyopathy distal dreifuss dystrophy echocardiogram emery exon hemizygous hypertrophic linked missense muscle muscular myopathy occurring pathology postural predominantly reducing scapuloperoneal sequencing vacuolar wasting weakness
Tagcloud (Intersection) ?