TXNIP and DDIT4

Number of citations of the paper that reports this interaction (PMID 21460850)
14

Data Source:
BioGRID (pull down, affinity chromatography technology, imaging technique)

		TXNIP	DDIT4
Gene Name		thioredoxin interacting protein	DNA-damage-inducible transcript 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Intermembrane Space Cytosol	Intracellular Cytoplasm Mitochondrion Cytosol
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding	14-3-3 Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Protein Import Into Nucleus Cell Cycle Response To Mechanical Stimulus Response To Glucose Keratinocyte Differentiation Response To Estradiol Response To Progesterone Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Cell Proliferation Response To Drug Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Innate Immune Response Platelet-derived Growth Factor Receptor Signaling Pathway Response To Calcium Ion Negative Regulation Of Cell Division Cellular Response To Tumor Cell	Response To Hypoxia Neuron Migration Brain Development Cell Proliferation Negative Regulation Of Peptidyl-threonine Phosphorylation Neuron Differentiation Negative Regulation Of TOR Signaling Negative Regulation Of Peptidyl-serine Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Complex Disassembly Negative Regulation Of Glycolytic Process Neurotrophin TRK Receptor Signaling Pathway Defense Response To Virus Reactive Oxygen Species Metabolic Process Positive Regulation Of Neuron Death Negative Regulation Of Intracellular Signal Transduction
Pathways		The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: DDIT4 ECD FHL1 HDAC1 HDAC3 ITCH KPNA2 PRKAA1 SCEL SMURF2 TXN TXNRD1 ZBTB16 ZBTB32	5 interactors: GSK3B HSPA4 LRIF1 PDPK1 TXNIP
Entrez ID		10628	54541
HPRD ID		05964	09662
Ensembl ID		ENSG00000117289	ENSG00000168209
Uniprot IDs		Q9H3M7	Q9NX09
PDB IDs		4GEI 4GEJ	3LQ9
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Regulation Of Glycolytic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Regulation Of TOR Signaling Regulation Of Nitrogen Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Death Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Nucleobase-containing Compound Metabolic Process Nucleobase-containing Small Molecule Interconversion Cell Proliferation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Notch Signaling Pathway Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Carbohydrate Metabolic Process Histone H4 Deacetylation Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle RNA Metabolic Process Negative Regulation Of JNK Cascade Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Death Nitrogen Compound Metabolic Process Negative Regulation Of TOR Signaling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Reactive Oxygen Species Histone H3 Deacetylation Negative Regulation Of Stress-activated MAPK Cascade Histone H3-K9 Modification Regulation Of RNA Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Response To Stress Gene Expression Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor	Protein Localization To Organelle Extrinsic Apoptotic Signaling Pathway Cellular Response To Tumor Cell Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cytoplasmic Transport Phosphatidylinositol-mediated Signaling Negative Regulation Of Catalytic Activity Innate Immune Response Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Protein Import Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Response To Organic Substance Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Hypermethylation Of CpG Island Protein Import Into Mitochondrial Outer Membrane Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Response To Mechanical Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Response To Abiotic Stimulus Negative Regulation Of Kinase Activity Cellular Response To Interleukin-3 Positive Regulation Of Intracellular Transport Response To Tumor Cell Nucleocytoplasmic Transport Nuclear Transport Fc Receptor Signaling Pathway Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Immune Response Protein Localization To Microtubule Negative Regulation Of Transferase Activity Defense Response Cellular Protein Localization Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of Protein Phosphorylation Response To Metal Ion Negative Regulation Of NFAT Protein Import Into Nucleus Protein Transport
Tagcloud ?		another arrest better br breast bt474 causes corresponding g1 indicated inversely little marker microarray noncancerous os p27 plays previous prognostic r regarding sk strong taken thioredoxin tissue transfection validated	activates anticancer atf4 attenuated autophagy cebpb chip depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Difference) ?		another arrest better br breast bt474 causes corresponding g1 indicated inversely little marker microarray noncancerous os p27 plays previous prognostic r regarding sk strong taken thioredoxin tissue transfection validated	activates anticancer atf4 attenuated autophagy cebpb chip depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Intersection) ?