TXNIP and ECD

Number of citations of the paper that reports this interaction (PMID 23880345)
0

Data Source:
BioGRID (affinity chromatography technology, pull down, two hybrid)

		TXNIP	ECD
Gene Name		thioredoxin interacting protein	ecdysoneless homolog (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Intermembrane Space Cytosol	Nucleoplasm Cytoplasm
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding	Transcription Coactivator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Protein Import Into Nucleus Cell Cycle Response To Mechanical Stimulus Response To Glucose Keratinocyte Differentiation Response To Estradiol Response To Progesterone Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Cell Proliferation Response To Drug Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Innate Immune Response Platelet-derived Growth Factor Receptor Signaling Pathway Response To Calcium Ion Negative Regulation Of Cell Division Cellular Response To Tumor Cell	Regulation Of Glycolytic Process Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cell Proliferation Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: DDIT4 ECD FHL1 HDAC1 HDAC3 ITCH KPNA2 PRKAA1 SCEL SMURF2 TXN TXNRD1 ZBTB16 ZBTB32	4 interactors: EWSR1 NR3C1 PSEN2 TXNIP
Entrez ID		10628	11319
HPRD ID		05964	11032
Ensembl ID		ENSG00000117289	ENSG00000122882
Uniprot IDs		Q9H3M7	O95905
PDB IDs		4GEI 4GEJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Regulation Of Glycolytic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Regulation Of TOR Signaling Regulation Of Nitrogen Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Death Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Nucleobase-containing Compound Metabolic Process Nucleobase-containing Small Molecule Interconversion Cell Proliferation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Notch Signaling Pathway Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Carbohydrate Metabolic Process Histone H4 Deacetylation Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle RNA Metabolic Process Negative Regulation Of JNK Cascade Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Death Nitrogen Compound Metabolic Process Negative Regulation Of TOR Signaling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Reactive Oxygen Species Histone H3 Deacetylation Negative Regulation Of Stress-activated MAPK Cascade Histone H3-K9 Modification Regulation Of RNA Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Response To Stress Gene Expression Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor	Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Response To Tumor Cell Glucocorticoid Mediated Signaling Pathway Epithelium Development Intracellular Receptor Signaling Pathway Negative Regulation Of Glucocorticoid Mediated Signaling Pathway Skin Development Epidermis Development Regulation Of Apoptotic Process Regulation Of Glucocorticoid Mediated Signaling Pathway Response To Tumor Cell Regulation Of Cell Death Glucocorticoid Receptor Signaling Pathway Regulation Of Glucocorticoid Biosynthetic Process Tissue Development Regulation Of Glucocorticoid Metabolic Process Amyloid Precursor Protein Catabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Steroid Hormone Maternal Behavior Gland Development Regulation Of Cellular Ketone Metabolic Process Glucocorticoid Metabolic Process Membrane Protein Intracellular Domain Proteolysis Nitrogen Compound Metabolic Process Membrane Protein Ectodomain Proteolysis Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Transcription, DNA-templated Behavior Notch Receptor Processing RNA Biosynthetic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Hormone Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Tube Development Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Hormone Metabolic Process Dorsal/ventral Neural Tube Patterning Membrane Protein Proteolysis Positive Regulation Of Coagulation Adrenal Gland Development Brain Morphogenesis Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Tagcloud ?		another arrest better br breast bt474 causes corresponding g1 indicated inversely little marker microarray noncancerous os p27 plays previous prognostic r regarding sk strong taken thioredoxin tissue transfection validated	ascites baculovirus boost dodecyl ectodomain epitope epitopes fluids folded htshr hybridoma hybridomas hyperimmunize intraperitoneally isotype m3 m4 m5 m6 m9 mabs monoclonals monophosphate mtshr refolded spanning spleens thyrotropin unfolding
Tagcloud (Difference) ?		another arrest better br breast bt474 causes corresponding g1 indicated inversely little marker microarray noncancerous os p27 plays previous prognostic r regarding sk strong taken thioredoxin tissue transfection validated	ascites baculovirus boost dodecyl ectodomain epitope epitopes fluids folded htshr hybridoma hybridomas hyperimmunize intraperitoneally isotype m3 m4 m5 m6 m9 mabs monoclonals monophosphate mtshr refolded spanning spleens thyrotropin unfolding
Tagcloud (Intersection) ?