TXNIP and ZBTB32

Number of citations of the paper that reports this interaction (PubMedID 12821938)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		TXNIP	ZBTB32
Description		thioredoxin interacting protein	zinc finger and BTB domain containing 32
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Inflammatory Response Response To Oxidative Stress Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Glucose Protein Transport Keratinocyte Differentiation Response To Estradiol Response To Progesterone Regulation Of Cell Population Proliferation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Response To Calcium Ion Negative Regulation Of Cell Division Cellular Response To Tumor Cell Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process Negative Regulation Of DNA-templated Transcription
Pathways		The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection Cytoprotection by HMOX1
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278)
Interacting Genes		30 interacting genes: CBX8 DDIT4 ECD EEF1A1 FHL1 GAPDH HDAC1 HDAC3 HSPB2 IDI1 INTS9 KPNA2 LUC7L3 MAPK1 NLGN3 PRKAA1 PTPN11 RUVBL2 SCEL SIVA1 SLC2A1 SMURF2 TRAF6 TXN TXNRD1 UBR5 UXT WWP1 ZBTB16 ZBTB32	54 interacting genes: ANKS1A AR ATXN1 ATXN1L BLK BOLL CAMK2A CAMK2B CCDC102B CDKN2D CFAP206 DAB1 DAZAP2 E2F6 ELF2 ERVK-6 FANCC GATA2 HNRNPF HOXD4 KRTAP15-1 KRTAP19-5 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 MIEN1 MLX MVP MYO15B OXER1 PATZ1 PITX1 PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB1 RBPMS RBPMS2 RHOXF2 SHARPIN SPAG8 SPMIP9 TFAP2D TLX3 TNPO2 TXNIP VENTX WWOX ZBTB16 ZNF490
Entrez ID		10628	27033
HPRD ID		05964	12055
Ensembl ID		ENSG00000265972	ENSG00000011590
Uniprot IDs		Q9H3M7	A0A0C4DGF1 Q9Y2Y4
PDB IDs		4GEI 4GEJ 4GFX 4LL1 4LL4 4ROF 4ROJ 5CQ2 5DF6 5DWS 5DZD	3M5B
Enriched GO Terms of Interacting Partners?		Nucleus Cytosol Cytoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Protein Lysine Delactylase Activity Regulation Of Signal Transduction Positive Regulation Of Type I Interferon Production Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Nucleoplasm Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Export From Nucleus Regulation Of Protein Stability Regulation Of Gene Expression Positive Regulation Of Signal Transduction Protein Modification Process Regulation Of Cell Communication Regulation Of Macromolecule Biosynthetic Process Regulation Of Signaling Regulation Of RNA Metabolic Process Regulation Of Nucleocytoplasmic Transport Thioredoxin-disulfide Reductase (NADPH) Activity Regulation Of Canonical Wnt Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Type I Interferon Production Histone Deacetylase Binding Negative Regulation Of Protein Export From Nucleus Transcription Corepressor Binding Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Transport Response To Epidermal Growth Factor Regulation Of Intracellular Protein Transport Histone Deacetylase Activity, Hydrolytic Mechanism Bergmann Glial Cell Differentiation	Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity POZ Domain Binding Intermediate Filament Regulation Of Nucleobase-containing Compound Metabolic Process Keratinization Sequence-specific Double-stranded DNA Binding Calcium- And Calmodulin-dependent Protein Kinase Complex Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process GABAergic Neuron Differentiation Male Germ Cell Nucleus Cytosol Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding
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