TXNIP and ZBTB32

Number of citations of the paper that reports this interaction (PMID 12821938)
49

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		TXNIP	ZBTB32
Gene Name		thioredoxin interacting protein	zinc finger and BTB domain containing 32
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Intermembrane Space Cytosol	Nuclear Chromosome Nucleus Nucleoplasm
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding	DNA Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Protein Import Into Nucleus Cell Cycle Response To Mechanical Stimulus Response To Glucose Keratinocyte Differentiation Response To Estradiol Response To Progesterone Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Cell Proliferation Response To Drug Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Innate Immune Response Platelet-derived Growth Factor Receptor Signaling Pathway Response To Calcium Ion Negative Regulation Of Cell Division Cellular Response To Tumor Cell	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cytokine Production DNA Repair Transcription From RNA Polymerase II Promoter Hemopoiesis T Cell Proliferation
Pathways		The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System	Fanconi Anemia pathway Regulation of the Fanconi anemia pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: DDIT4 ECD FHL1 HDAC1 HDAC3 ITCH KPNA2 PRKAA1 SCEL SMURF2 TXN TXNRD1 ZBTB16 ZBTB32	17 interactors: AR ATXN1 DAB1 ELF2 ERVK-6 FANCC GATA2 HOXD4 MLX MVP PITX1 PRKAB2 RBPMS RHOXF2 TXNIP ZBTB16 ZNF490
Entrez ID		10628	27033
HPRD ID		05964	12055
Ensembl ID		ENSG00000117289	ENSG00000011590
Uniprot IDs		Q9H3M7	Q9Y2Y4
PDB IDs		4GEI 4GEJ	3M5B
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Regulation Of Glycolytic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Regulation Of TOR Signaling Regulation Of Nitrogen Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Death Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Nucleobase-containing Compound Metabolic Process Nucleobase-containing Small Molecule Interconversion Cell Proliferation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Notch Signaling Pathway Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Carbohydrate Metabolic Process Histone H4 Deacetylation Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle RNA Metabolic Process Negative Regulation Of JNK Cascade Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Death Nitrogen Compound Metabolic Process Negative Regulation Of TOR Signaling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Reactive Oxygen Species Histone H3 Deacetylation Negative Regulation Of Stress-activated MAPK Cascade Histone H3-K9 Modification Regulation Of RNA Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Response To Stress Gene Expression Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Embryonic Hindlimb Morphogenesis Pituitary Gland Development Ventral Spinal Cord Development Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of Integrin Biosynthetic Process Cellular Response To Tumor Cell Hindlimb Morphogenesis Nucleocytoplasmic Transport Nuclear Transport Cellular Metabolic Process Negative Regulation Of Signaling Regulation Of Cellular Process Developmental Process Involved In Reproduction Cerebellum Structural Organization
Tagcloud ?		another arrest better br breast bt474 causes corresponding g1 indicated inversely little marker microarray noncancerous os p27 plays previous prognostic r regarding sk strong taken thioredoxin tissue transfection validated
Tagcloud (Difference) ?		another arrest better br breast bt474 causes corresponding g1 indicated inversely little marker microarray noncancerous os p27 plays previous prognostic r regarding sk strong taken thioredoxin tissue transfection validated
Tagcloud (Intersection) ?