TXNIP and NLGN3

Number of citations of the paper that reports this interaction (PubMedID 25464930)
0

Data Source:
BioGRID (two hybrid)

		TXNIP	NLGN3
Description		thioredoxin interacting protein	neuroligin 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Plasma Membrane Cell Surface Membrane Endocytic Vesicle Synapse Postsynaptic Membrane Excitatory Synapse Presynapse Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Asymmetric, Glutamatergic, Excitatory Synapse
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding Signaling Receptor Activity Neurexin Family Protein Binding Cell Adhesion Molecule Binding Scaffold Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Inflammatory Response Response To Oxidative Stress Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Glucose Protein Transport Keratinocyte Differentiation Response To Estradiol Response To Progesterone Regulation Of Cell Population Proliferation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Response To Calcium Ion Negative Regulation Of Cell Division Cellular Response To Tumor Cell Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Receptor-mediated Endocytosis Cell Adhesion Neuron Cell-cell Adhesion Chemical Synaptic Transmission Synapse Assembly Learning Adult Behavior Social Behavior Synaptic Vesicle Endocytosis Axon Extension Modulation Of Chemical Synaptic Transmission Synapse Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Rhythmic Synaptic Transmission Inhibitory Postsynaptic Potential Vocalization Behavior Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynapse Assembly Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection Cytoprotection by HMOX1	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS			Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Prostate cancer ( 25217961)
Interacting Genes		30 interacting genes: CBX8 DDIT4 ECD EEF1A1 FHL1 GAPDH HDAC1 HDAC3 HSPB2 IDI1 INTS9 KPNA2 LUC7L3 MAPK1 NLGN3 PRKAA1 PTPN11 RUVBL2 SCEL SIVA1 SLC2A1 SMURF2 TRAF6 TXN TXNRD1 UBR5 UXT WWP1 ZBTB16 ZBTB32	65 interacting genes: AKT1 ALPP AP2A2 APC2 ATF4 ATXN1 C1orf122 C1QA CCAR2 CGB3 COBL CTSD DLG2 DLG3 DLG4 DPEP2 EBPL EFEMP1 EFS FANCG FBLN1 FHOD1 FKBP1A FLNA GDF15 GUK1 HID1 HIVEP1 ITPRIP LGALS1 MAN2C1 MAP1S MEOX2 MIEN1 NFATC4 NRDC NRXN1 NRXN2 NRXN3 OAZ1 OR1F12P PICK1 PKIB PLB1 PLCB4 PRDX2 PSAP PSG1 PSG11 PSG3 PSG4 PSG5 QARS1 RBFOX2 SPAG5 SPINT1 SSR4 TDRD7 TLE5 TNNT3 TRIM33 TXNIP UBQLN1 UBXN6 UQCRC1
Entrez ID		10628	54413
HPRD ID		05964	02275
Ensembl ID		ENSG00000265972	ENSG00000196338
Uniprot IDs		Q9H3M7	A0A8I5KSB7 A0A8I5QJH8 B7Z3P8 Q4G160 Q9NZ94 X5D2P6 X5D7L6 X5DNV3
PDB IDs		4GEI 4GEJ 4GFX 4LL1 4LL4 4ROF 4ROJ 5CQ2 5DF6 5DWS 5DZD	8GS3
Enriched GO Terms of Interacting Partners?		Nucleus Cytosol Cytoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Protein Lysine Delactylase Activity Regulation Of Signal Transduction Positive Regulation Of Type I Interferon Production Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Nucleoplasm Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Export From Nucleus Regulation Of Protein Stability Regulation Of Gene Expression Positive Regulation Of Signal Transduction Protein Modification Process Regulation Of Cell Communication Regulation Of Macromolecule Biosynthetic Process Regulation Of Signaling Regulation Of RNA Metabolic Process Regulation Of Nucleocytoplasmic Transport Thioredoxin-disulfide Reductase (NADPH) Activity Regulation Of Canonical Wnt Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Type I Interferon Production Histone Deacetylase Binding Negative Regulation Of Protein Export From Nucleus Transcription Corepressor Binding Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Transport Response To Epidermal Growth Factor Regulation Of Intracellular Protein Transport Histone Deacetylase Activity, Hydrolytic Mechanism Bergmann Glial Cell Differentiation	Receptor Clustering Neuroligin Family Protein Binding Kinase Binding Protein Localization To Cell Junction Vocalization Behavior Social Behavior Protein Localization To Synapse Female Pregnancy Protein Localization To Membrane Cell-cell Adhesion Neuron Cell-cell Adhesion Receptor Localization To Synapse Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Cellular Response To Metal Ion Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway GDF15-GFRAL Signaling Pathway Somite Specification Gephyrin Clustering Involved In Postsynaptic Density Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Localization Within Membrane Ionotropic Glutamate Receptor Binding NMDA Selective Glutamate Receptor Signaling Pathway Trans-synaptic Protein Complex Postsynaptic Density Protein 95 Clustering Negative Regulation Of Signal Transduction Neuromuscular Junction Postsynapse Response To Metal Ion Negative Regulation Of Apoptotic Signaling Pathway Postsynaptic Membrane Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Learning Vocal Learning Cell Adhesion Cell-cell Signaling GMP Kinase Activity Postsynaptic Membrane Organization Neurotransmitter Secretion Observational Learning Cellular Localization Learning Or Memory Protein Kinase Inhibitor Activity Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signaling Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway PERK-mediated Unfolded Protein Response GDP Metabolic Process
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