PFKP and AGO2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PFKP	AGO2
Gene Name		phosphofructokinase, platelet	argonaute RISC catalytic component 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Membrane Extracellular Vesicular Exosome	Cytoplasmic MRNA Processing Body Nucleoplasm Cytoplasm Cytosol Polysome MRNA Cap Binding Complex Membrane RISC Complex Ribonucleoprotein Complex Micro-ribonucleoprotein Complex
	Molecular Function	6-phosphofructokinase Activity ATP Binding Protein Complex Binding Metal Ion Binding	RNA 7-methylguanosine Cap Binding MRNA Binding Translation Initiation Factor Activity Endoribonuclease Activity Protein Binding SiRNA Binding MiRNA Binding Poly(A) RNA Binding Metal Ion Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA
	Biological Process	Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Glycolytic Process Pathogenesis Small Molecule Metabolic Process Carbohydrate Phosphorylation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Translation Translational Initiation Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Post-embryonic Development Gene Expression MiRNA Metabolic Process Posttranscriptional Gene Silencing Gene Silencing By RNA Pre-miRNA Processing SiRNA Loading Onto RISC Involved In RNA Interference Negative Regulation Of Translation Involved In Gene Silencing By MiRNA MRNA Cleavage Involved In Gene Silencing By MiRNA Fc-epsilon Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Translational Initiation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways		Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Regulatory RNA pathways Signaling by Wnt Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Pre-NOTCH Transcription and Translation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Pre-NOTCH Expression and Processing Post-transcriptional silencing by small RNAs Innate Immune System Signaling by PDGF Transcriptional regulation by small RNAs Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 MicroRNA (miRNA) biogenesis Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR beta-catenin independent WNT signaling Signaling by ERBB2 Signaling by EGFR Ca2+ pathway Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Small interfering RNA (siRNA) biogenesis Adaptive Immune System
Drugs
Diseases
GWAS		Disc degeneration (lumbar) ( 22993228)
Protein-Protein Interactions		7 interactors: ACD AGO2 DYNLL1 POT1 TERF1 TINF2 WNK1	15 interactors: AGO1 BTRC DCP1A DCP2 DDX20 DHX58 DICER1 GEMIN4 MIRLET7B MIRLET7I PFKP PRKRA TARBP2 TBK1 TBKBP1
Entrez ID		5214	27161
HPRD ID		01384	06943
Ensembl ID		ENSG00000067057	ENSG00000123908
Uniprot IDs		Q01813	A4FVC0 Q9UKV8
PDB IDs			3LUC 3LUD 3LUG 3LUH 3LUJ 3LUK 3QX8 3QX9 4EI1 4EI3 4F3T
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of DNA Replication Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of Telomerase Activity Negative Regulation Of DNA Metabolic Process Regulation Of DNA Replication Negative Regulation Of Cellular Metabolic Process Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomere Capping Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Telomerase Activity Regulation Of Organelle Organization Positive Regulation Of Organelle Organization Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of DNA Biosynthetic Process RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Protein Localization To Chromosome Negative Regulation Of Cellular Protein Metabolic Process Cellular Component Assembly Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Transferase Activity Chromosome Organization DNA Metabolic Process Positive Regulation Of DNA Replication Regulation Of Catalytic Activity Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Homeostatic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process G2/M Transition Of Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process MRNA Cleavage Involved In Gene Silencing By MiRNA	Production Of SiRNA Involved In RNA Interference Posttranscriptional Gene Silencing RNA Interference Gene Silencing By RNA Gene Silencing Gene Silencing By MiRNA Cellular Response To DsRNA Targeting Of MRNA For Destruction Involved In RNA Interference Ribonucleoprotein Complex Assembly Negative Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression NcRNA Metabolic Process Regulation Of Gene Expression, Epigenetic Response To DsRNA MRNA Metabolic Process RNA Processing Pre-miRNA Processing Response To Virus Ribonucleoprotein Complex Biogenesis Production Of MiRNAs Involved In Gene Silencing By MiRNA Cellular Response To Organic Cyclic Compound Cellular Macromolecule Catabolic Process Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Defense Response To Virus RNA Metabolic Process Aromatic Compound Catabolic Process MRNA Catabolic Process Defense Response To Virus Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Catabolic Process Gene Expression Catabolic Process Spliceosomal SnRNP Assembly Negative Regulation Of Type I Interferon Production Cellular Macromolecular Complex Assembly Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Immune Response Response To Other Organism Defense Response Response To Biotic Stimulus Immune System Process Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Hair Follicle Cell Proliferation Conversion Of Ds SiRNA To Ss SiRNA Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Type I Interferon Production Regulation Of Defense Response To Virus Nucleobase-containing Compound Metabolic Process
Tagcloud ?		450k akr1b1 akt3 array beadchip belonging cdkl2 custom dbx1 epitect focusing foxc2 hk1 homeobox humanmethylation450 illumina ina infinium irf4 lowered methylation multicellular neurod1 nkx2 overrepresentation signature six6 top warranted	acf acriflavine aerosol alphaviruses avenue bioterror capsid degrading downregulating encephalitic encephalitis equine equines licensed loads master nile priority publications resultant risc stomatitis titers trd veev venezuelan vesicular virulent weapon
Tagcloud (Difference) ?		450k akr1b1 akt3 array beadchip belonging cdkl2 custom dbx1 epitect focusing foxc2 hk1 homeobox humanmethylation450 illumina ina infinium irf4 lowered methylation multicellular neurod1 nkx2 overrepresentation signature six6 top warranted	acf acriflavine aerosol alphaviruses avenue bioterror capsid degrading downregulating encephalitic encephalitis equine equines licensed loads master nile priority publications resultant risc stomatitis titers trd veev venezuelan vesicular virulent weapon
Tagcloud (Intersection) ?