SAMM50 and MAP1LC3B

Number of citations of the paper that reports this interaction (PubMedID 34037656)
114

Data Source:
BioGRID (pull down)

		SAMM50	MAP1LC3B
Description		SAMM50 sorting and assembly machinery component	microtubule associated protein 1 light chain 3 beta
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GO Annotations	Cellular Component	SAM Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Outer Membrane Extracellular Exosome MIB Complex	Autophagosome Membrane Cytoplasm Mitochondrion Autophagosome Cytosol Cytoskeleton Microtubule Axoneme Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Mitochondrial Membrane
	Molecular Function	Protein Binding	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Ceramide Binding
	Biological Process	Inner Mitochondrial Membrane Organization Protein Import Into Mitochondrial Matrix Cristae Formation Protein Insertion Into Mitochondrial Outer Membrane	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Cellular Response To Nitrogen Starvation Cellular Response To Starvation Macroautophagy Autophagosome Maturation
Pathways		Mitochondrial protein import Cristae formation RAC2 GTPase cycle	Macroautophagy PINK1-PRKN Mediated Mitophagy TBC/RABGAPs Receptor Mediated Mitophagy Pexophagy Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex SARS-CoV-2 modulates autophagy KEAP1-NFE2L2 pathway
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 30718733) Cholesterol, total ( 26780889) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757) Metabolite levels ( 23823483) Nonalcoholic fatty liver disease ( 22719876 29271184 29385134 34841290) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Total cholesterol levels ( 28334899) Type 2 diabetes ( 30054458)	General factor of neuroticism ( 30867560) Major depressive disorder ( 22472876) Metabolite levels ( 23823483) Neuroticism ( 29255261) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: A1BG CHCHD3 CHCHD6 GABARAP HMGB2 MAP1LC3B MAP1LC3C MEOX2 UBC VDAC1	97 interacting genes: AAMP ABTB3 ADD1 ADNP AFTPH AMBRA1 ANK2 APPL1 ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4C ATG4D ATG7 BAG6 BIRC6 BNIP3 BRD3 BRD9 CAMSAP1 CARS2 CASP8 CCDC50 CCPG1 CCSER2 CDC37 CLTA CUL3 DBI DBN1 DNMT3B DPPA4 EED EPS8 EVA1A FLCN FUNDC1 GORASP2 HYPK IRGQ KBTBD7 KLHL5 KXD1 LUC7L2 MESD MKRN1 MRFAP1 MRTFA MTX1 MYBL2 NCOR1 NEDD4 NEK9 OPTN PCNT PLEKHM1 PRKCZ PRUNE2 RAD1 RAP1GAP RASAL3 RETREG1 RETREG2 RIC1 RIPOR1 RPLP1 SAMM50 SEM1 SEPTIN3 SMARCB1 SNCA SNU13 SNX18 SPAG9 SQSTM1 STK3 STK36 TAF7 TBC1D17 TBC1D25 TBC1D5 TBC1D9 TBC1D9B THAP7 TMOD3 TNIP1 TPPP TRIM21 TRIM25 TRIM32 TTN UPF2 USP10 VHL WDR90
Entrez ID		25813	81631
HPRD ID		10826	14358
Ensembl ID		ENSG00000100347	ENSG00000140941
Uniprot IDs		Q9Y512	Q658J6 Q9GZQ8
PDB IDs		6YOO 6YOP	1V49 2LUE 2N9X 2ZJD 3VTU 3VTV 3VTW 3WAO 3X0W 4WAA 5D94 5DCN 5GMV 5MS2 5MS5 5MS6 5V4K 5W9A 5XAC 5XAD 5XAE 6J04 6LAN 7ELG 7GA8 7GA9 7GAA 7GAB 7GAC 7GAD 7GAE 7GAF 7GAG 7GAH 7GAI 7GAJ 7GAK 7GAL 7GAM 7GAN 7GAO 7GAP 7GAQ 7GAR 7GAS 7GAU 8Q53 8Q7K 8YV6
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagosome Membrane Autophagosome Maturation Mitochondrial Crista Junction MICOS Complex Autophagy Of Mitochondrion Ceramide Binding Autophagosome SAM Complex MIB Complex Ubiquitin Protein Ligase Binding Autophagosome Assembly Cristae Formation Autophagosome Organization Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Cellular Response To Starvation Inner Mitochondrial Membrane Organization Response To Starvation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Organelle Membrane Cellular Response To Nutrient Levels Endomembrane System Autophagy Microtubule Cellular Response To Stress Non-sequence-specific DNA Binding, Bending Mitochondrion Organelle Organization Negative Regulation Of Calcium Import Into The Mitochondrion Positive Regulation Of Protein K48-linked Ubiquitination Mitochondrial Membrane Organization Extrinsic Apoptotic Signaling Pathway Axoneme Response To Nutrient Levels Somite Specification Voltage-gated Monoatomic Anion Channel Activity Supercoiled DNA Binding Porin Activity Regulation Of Calcium Import Into The Mitochondrion Regulation Of Protein K48-linked Ubiquitination Response To Stress Mitochondrial Permeability Transition Pore Complex DNA Geometric Change Mitochondrial Membrane Neuron-neuron Synaptic Transmission	Autophagy Autophagy Of Mitochondrion Mitophagy Macroautophagy Autophagosome Autophagosome Assembly Autophagosome Organization Nucleophagy Organelle Organization Regulation Of Autophagy Vacuole Organization Organelle Assembly Piecemeal Microautophagy Of The Nucleus Protein-phosphatidylethanolamide Deconjugating Activity Microautophagy Catabolic Process Positive Regulation Of Autophagy Protein Delipidation Aggrephagy Cellular Component Assembly Establishment Of Protein Localization Cytoplasm Substrate Localization To Autophagosome Intracellular Protein Localization Protein Transport Protein Binding Positive Regulation Of Catabolic Process Cytosol Endoplasmic Reticulum-autophagosome Adaptor Activity Cellular Localization Establishment Of Localization In Cell Regulation Of Protein Stability Proteolysis Involved In Protein Catabolic Process Cysteine-type Endopeptidase Activity Regulation Of Cellular Component Organization Response To Mitochondrial Depolarisation Proteolysis Regulation Of Organelle Organization Regulation Of Macroautophagy Protein Monoubiquitination GTPase Activator Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Macroautophagy Phagophore Assembly Site Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Catabolic Process Regulation Of Cell Projection Assembly
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