SAMM50 and MAP1LC3C

Number of citations: 114 (PubMedID 34037656)
Data Source: BioGRID (pull down)

		SAMM50	MAP1LC3C
Name		SAMM50 sorting and assembly machinery component	microtubule associated protein 1 light chain 3 gamma
Structure
GO Annotations	Cellular Component	SAM Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Outer Membrane Extracellular Exosome MIB Complex	Autophagosome Membrane Cytoplasm Autophagosome Cytosol Cytoskeleton Microtubule Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Protein Binding	Protein Binding Phospholipid Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding
	Biological Process	Inner Mitochondrial Membrane Organization Protein Import Into Mitochondrial Matrix Cristae Formation Protein Insertion Into Mitochondrial Outer Membrane	Autophagosome Assembly Mitophagy Autophagy Response To Stress Cellular Response To Nitrogen Starvation Cellular Response To Starvation Macroautophagy Protein Exit From Endoplasmic Reticulum Aggrephagy Autophagosome Maturation
Pathways		Mitochondrial protein import Cristae formation RAC2 GTPase cycle	Macroautophagy
GWAS		Alanine aminotransferase levels ( 30718733 ) Cholesterol, total ( 26780889 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Hematological and biochemical traits ( 20139978 ) Liver enzyme levels ( 18940312 ) Liver enzyme levels (alanine transaminase) ( 22001757 ) Metabolite levels ( 23823483 ) Nonalcoholic fatty liver disease ( 22719876 29271184 29385134 34841290 ) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134 ) Pediatric non-alcoholic fatty liver disease activity score ( 23535911 ) Total cholesterol levels ( 28334899 ) Type 2 diabetes ( 30054458 )	Hip circumference adjusted for BMI ( 28552196 ) Metabolite levels ( 23823483 )
Interacting Genes		10 interacting genes: A1BG CHCHD3 CHCHD6 GABARAP HMGB2 MAP1LC3B MAP1LC3C MEOX2 UBC VDAC1	41 interacting genes: AMBRA1 ANK2 ANK3 APPL1 ATG13 ATXN3 BICC1 CALCOCO2 CAPN3 CDC37 CUL3 GMEB2 IRGM KBTBD6 KBTBD7 LAT LMNB1 MEFV MISP NCOR1 NEDD4 NIPBL OPRM1 OPTN PDLIM1 RESF1 RHOXF1 RUFY4 SAMM50 STK3 TAX1BP1 TBC1D25 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 TSR2 WDFY3 WDR81 ZNF24
Entrez ID		25813	440738
HPRD ID		10826	14226
Ensembl ID		ENSG00000100347	ENSG00000197769
Uniprot IDs		Q9Y512	Q9BXW4
PDB IDs		6YOO 6YOP	2NCN 3VVW 3WAM 3WAP 5DPW
GO Terms Enriched among Interactors		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagosome Membrane Autophagosome Maturation Mitochondrial Crista Junction MICOS Complex Autophagy Of Mitochondrion Ceramide Binding Autophagosome SAM Complex MIB Complex Ubiquitin Protein Ligase Binding Autophagosome Assembly Cristae Formation Autophagosome Organization Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Cellular Response To Starvation Inner Mitochondrial Membrane Organization Response To Starvation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Organelle Membrane Cellular Response To Nutrient Levels Endomembrane System Autophagy Microtubule Cellular Response To Stress Non-sequence-specific DNA Binding, Bending Mitochondrion Organelle Organization Negative Regulation Of Calcium Import Into The Mitochondrion Positive Regulation Of Protein K48-linked Ubiquitination Mitochondrial Membrane Organization Extrinsic Apoptotic Signaling Pathway Axoneme Response To Nutrient Levels Somite Specification Voltage-gated Monoatomic Anion Channel Activity Supercoiled DNA Binding Porin Activity Regulation Of Calcium Import Into The Mitochondrion Regulation Of Protein K48-linked Ubiquitination Response To Stress Mitochondrial Permeability Transition Pore Complex DNA Geometric Change Mitochondrial Membrane Neuron-neuron Synaptic Transmission	Autophagosome Positive Regulation Of Autophagy Regulation Of Autophagy Autophagy Positive Regulation Of Catabolic Process Regulation Of Macroautophagy Catabolic Process Autophagosome Assembly Positive Regulation Of Macroautophagy Autophagosome Organization Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Protein Polyubiquitination Vacuole Organization Protein K48-linked Ubiquitination Regulation Of Intracellular Signal Transduction Cytosol Organelle Organization Regulation Of Cell Communication Cytoplasmic Vesicle Regulation Of Innate Immune Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Localization To Organelle Macroautophagy Regulation Of Protein Stability Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Signal Transduction Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Innate Immune Response-activating Signaling Pathway Organelle Assembly Ubiquitin-dependent Protein Catabolic Process Protein Localization To Phagocytic Vesicle Regulation Of Autophagosome Maturation Modification-dependent Protein Catabolic Process Cytoplasm Regulation Of Gene Expression Intracellular Protein Localization Regulation Of Macromolecule Metabolic Process Suppression Of Viral Release By Host Autophagosome Membrane Regulation Of Signaling Activation Of Innate Immune Response Protein Monoubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Macromolecule Biosynthetic Process Protein-macromolecule Adaptor Activity