SAMM50 and A1BG

Number of citations: 114 (PubMedID 34037656)
Data Source: BioGRID (pull down, affinity chromatography technology)

		SAMM50	A1BG
Name		SAMM50 sorting and assembly machinery component	alpha-1-B glycoprotein
Structure			No pdb structure
GO Annotations	Cellular Component	SAM Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Outer Membrane Extracellular Exosome MIB Complex	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding	None
	Biological Process	Inner Mitochondrial Membrane Organization Protein Import Into Mitochondrial Matrix Cristae Formation Protein Insertion Into Mitochondrial Outer Membrane	Immune Response-regulating Signaling Pathway
Pathways		Mitochondrial protein import Cristae formation RAC2 GTPase cycle	Platelet degranulation Neutrophil degranulation
Drugs		None	Zinc Copper Zinc acetate
GWAS		Alanine aminotransferase levels ( 30718733 ) Cholesterol, total ( 26780889 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Hematological and biochemical traits ( 20139978 ) Liver enzyme levels ( 18940312 ) Liver enzyme levels (alanine transaminase) ( 22001757 ) Metabolite levels ( 23823483 ) Nonalcoholic fatty liver disease ( 22719876 29271184 29385134 34841290 ) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134 ) Pediatric non-alcoholic fatty liver disease activity score ( 23535911 ) Total cholesterol levels ( 28334899 ) Type 2 diabetes ( 30054458 )	No GWAS studies recorded
Interacting Genes		10 interacting genes: A1BG CHCHD3 CHCHD6 GABARAP HMGB2 MAP1LC3B MAP1LC3C MEOX2 UBC VDAC1	13 interacting genes: ABCC6 ANXA7 CDKN1A CRISP3 GRB7 HSP90AA1 MTX1 PRDX4 SAMM50 SETD7 SMN1 SNCA TK1
Entrez ID		25813	1
HPRD ID		10826	00726
Ensembl ID		ENSG00000100347	ENSG00000121410
Uniprot IDs		Q9Y512	P04217
PDB IDs		6YOO 6YOP	Not available
GO Terms Enriched among Interactors		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagosome Membrane Autophagosome Maturation Mitochondrial Crista Junction MICOS Complex Autophagy Of Mitochondrion Ceramide Binding Autophagosome SAM Complex MIB Complex Ubiquitin Protein Ligase Binding Autophagosome Assembly Cristae Formation Autophagosome Organization Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Cellular Response To Starvation Inner Mitochondrial Membrane Organization Response To Starvation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Organelle Membrane Cellular Response To Nutrient Levels Endomembrane System Autophagy Microtubule Cellular Response To Stress Non-sequence-specific DNA Binding, Bending Mitochondrion Organelle Organization Negative Regulation Of Calcium Import Into The Mitochondrion Positive Regulation Of Protein K48-linked Ubiquitination Mitochondrial Membrane Organization Extrinsic Apoptotic Signaling Pathway Axoneme Response To Nutrient Levels Somite Specification Voltage-gated Monoatomic Anion Channel Activity Supercoiled DNA Binding Porin Activity Regulation Of Calcium Import Into The Mitochondrion Regulation Of Protein K48-linked Ubiquitination Response To Stress Mitochondrial Permeability Transition Pore Complex DNA Geometric Change Mitochondrial Membrane Neuron-neuron Synaptic Transmission	Establishment Of Protein Localization To Mitochondrion SAM Complex MIB Complex Protein Insertion Into Mitochondrial Outer Membrane Response To Magnesium Ion Mitochondrial Membrane Organization Establishment Of Protein Localization To Organelle Protein Import Into Mitochondrial Matrix Protein Insertion Into Mitochondrial Membrane Establishment Of Protein Localization To Mitochondrial Membrane Protein Kinase Inhibitor Activity Protein Sequestering Activity Response To Cocaine Protein Localization To Mitochondrion Tau Protein Binding Inner Mitochondrial Membrane Organization Mitochondrial Outer Membrane CTP Binding DATP Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Mitochondrion Organization Membrane Organization Response To Xenobiotic Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Identical Protein Binding Protein Transmembrane Transport Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Protein Insertion Into Membrane Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Thymidine Kinase Activity Response To Metal Ion Regulation Of DNA Biosynthetic Process Response To Alkaloid DNA Biosynthetic Process Rho GDP-dissociation Inhibitor Binding Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Protein Tetramerization Negative Regulation Of Chaperone-mediated Autophagy DNA Synthesis Involved In Mitotic DNA Replication