SAMM50 and VDAC1

Number of citations: 114 (PubMedID 34037656)
Data Source: BioGRID (affinity chromatography technology, pull down)

		SAMM50	VDAC1
Name		SAMM50 sorting and assembly machinery component	voltage dependent anion channel 1
Structure
GO Annotations	Cellular Component	SAM Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Outer Membrane Extracellular Exosome MIB Complex	Nucleus Mitochondrion Mitochondrial Outer Membrane Mitochondrial Permeability Transition Pore Complex Plasma Membrane Membrane Mitochondrial Membrane Mitochondrial Nucleoid Membrane Raft Synapse Pore Complex Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding Voltage-gated Monoatomic Ion Channel Activity Protein Binding ATP Binding Oxysterol Binding Lipid Binding Voltage-gated Monoatomic Anion Channel Activity Porin Activity Cholesterol Binding Protein Kinase Binding Phosphatidylcholine Binding Identical Protein Binding Transmembrane Transporter Binding Ceramide Binding
	Biological Process	Inner Mitochondrial Membrane Organization Protein Import Into Mitochondrial Matrix Cristae Formation Protein Insertion Into Mitochondrial Outer Membrane	Behavioral Fear Response Monoatomic Ion Transport Monoatomic Anion Transport Lipid Transport Apoptotic Process Chemical Synaptic Transmission Neuron-neuron Synaptic Transmission Learning Epithelial Cell Differentiation Calcium Import Into The Mitochondrion Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Transmembrane Transport Monoatomic Anion Transmembrane Transport Negative Regulation Of Calcium Import Into The Mitochondrion Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Type 2 Mitophagy Mitochondrial Transmembrane Transport Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Mitochondrial protein import Cristae formation RAC2 GTPase cycle	Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases Pyruvate metabolism Mitochondrial calcium ion transport
Drugs		None	Aluminium monostearate Cannabidiol Medical Cannabis Nabiximols
GWAS		Alanine aminotransferase levels ( 30718733 ) Cholesterol, total ( 26780889 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Hematological and biochemical traits ( 20139978 ) Liver enzyme levels ( 18940312 ) Liver enzyme levels (alanine transaminase) ( 22001757 ) Metabolite levels ( 23823483 ) Nonalcoholic fatty liver disease ( 22719876 29271184 29385134 34841290 ) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134 ) Pediatric non-alcoholic fatty liver disease activity score ( 23535911 ) Total cholesterol levels ( 28334899 ) Type 2 diabetes ( 30054458 )	Alopecia areata ( 25608926 ) Metabolite levels ( 23823483 ) Systemic lupus erythematosus ( 28714469 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Interacting Genes		10 interacting genes: A1BG CHCHD3 CHCHD6 GABARAP HMGB2 MAP1LC3B MAP1LC3C MEOX2 UBC VDAC1	26 interacting genes: ADRB2 BAK1 BAX BCL2L1 BCL2L11 CKMT1A CKMT1B CSNK2B DUX4 DYNLT1 DYNLT3 GSN HK1 KLHL40 MCL1 PLAT PPIF PRKCE PRKN RAF1 RNF31 SAMM50 STUB1 SUMO4 TOMM20 TUBA4A
Entrez ID		25813	7416
HPRD ID		10826	05137
Ensembl ID		ENSG00000100347	ENSG00000213585
Uniprot IDs		Q9Y512	A0A1L1UHR1 B3KTS5 P21796
PDB IDs		6YOO 6YOP	2JK4 2K4T 5JDP 5XDN 5XDO 6G6U 6G73 6TIQ 6TIR 7QI2 8J0O
GO Terms Enriched among Interactors		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagosome Membrane Autophagosome Maturation Mitochondrial Crista Junction MICOS Complex Autophagy Of Mitochondrion Ceramide Binding Autophagosome SAM Complex MIB Complex Ubiquitin Protein Ligase Binding Autophagosome Assembly Cristae Formation Autophagosome Organization Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Cellular Response To Starvation Inner Mitochondrial Membrane Organization Response To Starvation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Organelle Membrane Cellular Response To Nutrient Levels Endomembrane System Autophagy Microtubule Cellular Response To Stress Non-sequence-specific DNA Binding, Bending Mitochondrion Organelle Organization Negative Regulation Of Calcium Import Into The Mitochondrion Positive Regulation Of Protein K48-linked Ubiquitination Mitochondrial Membrane Organization Extrinsic Apoptotic Signaling Pathway Axoneme Response To Nutrient Levels Somite Specification Voltage-gated Monoatomic Anion Channel Activity Supercoiled DNA Binding Porin Activity Regulation Of Calcium Import Into The Mitochondrion Regulation Of Protein K48-linked Ubiquitination Response To Stress Mitochondrial Permeability Transition Pore Complex DNA Geometric Change Mitochondrial Membrane Neuron-neuron Synaptic Transmission	Mitochondrial Outer Membrane Bcl-2 Family Protein Complex Apoptotic Mitochondrial Changes Regulation Of Release Of Cytochrome C From Mitochondria Mitochondrion Organization Mitochondrial Membrane Organization Mitochondrion Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrion Organization Extrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Release Of Cytochrome C From Mitochondria Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Membrane Permeability BH3 Domain Binding Regulation Of Mitochondrial Membrane Potential Regulation Of Apoptotic Signaling Pathway Cellular Response To Topologically Incorrect Protein Positive Regulation Of Mitochondrial Membrane Permeability Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Membrane Permeability Positive Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of Intracellular Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Channel Activity Programmed Cell Death Thymocyte Apoptotic Process Cell Death Leukocyte Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Programmed Cell Death Regulation Of Proteolysis Response To Stress Regulation Of IRE1-mediated Unfolded Protein Response BAK Complex B Cell Negative Selection Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Regulation Of Protein-containing Complex Assembly Cellular Response To Unfolded Protein Mitochondrial Fusion Positive Regulation Of Intracellular Signal Transduction Membrane Organization Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Establishment Of Protein Localization To Mitochondrion