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DICER1 and PRKAB2
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
DICER1
PRKAB2
Gene Name
dicer 1, ribonuclease type III
protein kinase, AMP-activated, beta 2 non-catalytic subunit
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
RISC Complex
Axon
Dendrite
Growth Cone
ARC Complex
Micro-ribonucleoprotein Complex
Nucleoplasm
Cytosol
AMP-activated Protein Kinase Complex
Molecular Function
Double-stranded RNA Binding
Helicase Activity
Endoribonuclease Activity
Ribonuclease III Activity
Deoxyribonuclease I Activity
Protein Binding
ATP Binding
MiRNA Binding
Metal Ion Binding
AMP-activated Protein Kinase Activity
Protein Binding
Identical Protein Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Angiogenesis
Apoptotic DNA Fragmentation
Post-embryonic Development
Zygote Asymmetric Cell Division
Gene Expression
Negative Regulation Of Schwann Cell Proliferation
Positive Regulation Of Gene Expression
Regulation Of Muscle Cell Apoptotic Process
Positive Regulation Of Schwann Cell Differentiation
Myoblast Differentiation Involved In Skeletal Muscle Regeneration
Stem Cell Maintenance
Spinal Cord Motor Neuron Differentiation
Nerve Development
Olfactory Bulb Interneuron Differentiation
Cerebral Cortex Development
Lung Development
Production Of SiRNA Involved In RNA Interference
Targeting Of MRNA For Destruction Involved In RNA Interference
Pre-miRNA Processing
Hair Follicle Morphogenesis
Positive Regulation Of Myelination
Peripheral Nervous System Myelin Formation
Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference
Embryonic Hindlimb Morphogenesis
Production Of MiRNAs Involved In Gene Silencing By MiRNA
Multicellular Organism Growth
Conversion Of Ds SiRNA To Ss SiRNA
Regulation Of Viral Genome Replication
Regulation Of Neuron Differentiation
MRNA Stabilization
Spleen Development
Reproductive Structure Development
Regulation Of Oligodendrocyte Differentiation
Branching Morphogenesis Of An Epithelial Tube
Neuron Projection Morphogenesis
Cartilage Development
Spindle Assembly
Defense Response To Virus
Regulation Of Cell Cycle
Cardiac Muscle Cell Development
Inner Ear Receptor Cell Development
Intestinal Epithelial Cell Development
Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
Ganglion Development
Regulation Of Enamel Mineralization
Hair Follicle Cell Proliferation
RNA Phosphodiester Bond Hydrolysis
RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Positive Regulation Of MiRNA Metabolic Process
Energy Reserve Metabolic Process
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Carnitine Shuttle
Organelle Organization
Mitochondrion Organization
Cell Cycle Arrest
Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Fatty Acid Biosynthetic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Regulation Of Protein Kinase Activity
Membrane Organization
Pathways
Regulatory RNA pathways
MicroRNA (miRNA) biogenesis
Small interfering RNA (siRNA) biogenesis
Organelle biogenesis and maintenance
Integration of energy metabolism
Metabolism of lipids and lipoproteins
Regulation of Rheb GTPase activity by AMPK
IRS-mediated signalling
mTOR signalling
Translocation of GLUT4 to the plasma membrane
Import of palmitoyl-CoA into the mitochondrial matrix
mTOR signalling
IGF1R signaling cascade
IRS-related events triggered by IGF1R
Energy dependent regulation of mTOR by LKB1-AMPK
PKB-mediated events
PI3K Cascade
Signaling by Insulin receptor
Fatty acid, triacylglycerol, and ketone body metabolism
Insulin receptor signalling cascade
Regulation of AMPK activity via LKB1
IRS-related events
Mitochondrial biogenesis
IRS-mediated signalling
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
AMPK inhibits chREBP transcriptional activation activity
PKB-mediated events
PI3K Cascade
Drugs
Adenosine monophosphate
Diseases
GWAS
Body mass index (interaction) (
23192594
)
Response to statin therapy (
20339536
)
Protein-Protein Interactions
11 interactors:
AGO1
AGO2
ALOX5
DHX58
EIF2AK2
PIWIL1
PIWIL2
PIWIL4
PRKAB2
PRKRA
TARBP2
70 interactors:
ADAMTSL4
BANP
BEND5
BLZF1
CALCOCO2
CASP6
CCDC33
CCDC36
CDX4
CREB3L1
CRX
CSNK2B
DAO
DDIT4L
DICER1
DST
EPM2A
FAM208B
FDX1
FLNC
GATA1
GATAD2B
GET4
GNB2L1
GOLGA2
GRN
IKZF1
IKZF3
KCTD5
KLF15
KRT40
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP4-12
KRTAP4-2
KRTAP5-9
KRTAP9-2
KRTAP9-4
LZTS2
MAGED1
MDFI
MEOX2
NEBL
PIAS2
PRDM14
PRKAA1
PRKAA2
PRKAG1
PRKAG2
PRKAG3
PSME3
PYGM
RBPMS
REL
RHEBL1
RIMBP3
SPRY2
STX11
STX19
TADA2A
TCF4
TP53BP2
TRAF2
TRIM10
UBXN11
YY1AP1
ZBTB32
Entrez ID
23405
5565
HPRD ID
05875
04117
Ensembl ID
ENSG00000100697
ENSG00000131791
Uniprot IDs
Q9UPY3
O43741
PDB IDs
2EB1
2F15
2V8Q
2V92
2V9J
2Y8L
2Y8Q
2Y94
2YA3
4EAI
4EAJ
Enriched GO Terms of Interacting Partners
?
Gene Silencing By RNA
Gene Silencing
Posttranscriptional Regulation Of Gene Expression
Regulation Of Translation
Regulation Of Gene Expression, Epigenetic
Posttranscriptional Gene Silencing
RNA Interference
Negative Regulation Of Gene Expression
NcRNA Metabolic Process
Negative Regulation Of Defense Response To Virus
PiRNA Metabolic Process
Gene Silencing By MiRNA
Regulation Of Cellular Protein Metabolic Process
Cellular Response To DsRNA
Regulation Of Protein Metabolic Process
Production Of SiRNA Involved In RNA Interference
Response To DsRNA
Regulation Of Defense Response To Virus
Negative Regulation Of Translation Involved In Gene Silencing By MiRNA
Pre-miRNA Processing
Negative Regulation Of Translation
RNA Metabolic Process
MiRNA Metabolic Process
Production Of MiRNAs Involved In Gene Silencing By MiRNA
Gene Expression
DNA Methylation Involved In Gamete Generation
Cellular Response To Organic Substance
RNA Processing
Meiotic Cell Cycle
Immune Response
Regulation Of Immune System Process
Nucleobase-containing Compound Metabolic Process
Defense Response
Response To Virus
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Gene Expression
Cellular Nitrogen Compound Metabolic Process
DNA Methylation
Innate Immune Response
Negative Regulation Of Cellular Protein Metabolic Process
Response To Organic Substance
Regulation Of Viral Genome Replication
Evasion Or Tolerance By Virus Of Host Immune Response
Leukotriene Production Involved In Inflammatory Response
Regulation Of Translational Initiation
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Immune System Process
Cellular Response To Organic Cyclic Compound
Nitrogen Compound Metabolic Process
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cell Cycle Arrest
Transcription, DNA-templated
Regulation Of Gene Expression
RNA Biosynthetic Process
Glycogen Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Glycolytic Process
Regulation Of Transcription, DNA-templated
Positive Regulation Of Metabolic Process
Positive Regulation Of Protein Phosphorylation
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Protein Modification Process
Negative Regulation Of Cell Cycle
Energy Reserve Metabolic Process
Regulation Of Cell Cycle
Regulation Of RNA Metabolic Process
Positive Regulation Of Gene Expression
Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Polysaccharide Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Macromolecule Biosynthetic Process
Organelle Organization
Gene Expression
Cell Cycle Process
Positive Regulation Of Phosphorylation
RNA Metabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Protein Metabolic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Signaling
Fatty Acid Biosynthetic Process
Cellular Process
Regulation Of Cellular Ketone Metabolic Process
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Transcription From RNA Polymerase II Promoter
Regulation Of Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Binding
Regulation Of Metabolic Process
Regulation Of Carbohydrate Metabolic Process
Regulation Of Phosphorylation
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of Cell Death
Tagcloud
?
adipocytes
adipogenesis
ctgdcrko
downregulated
fibrosis
follicular
goiter
goitrogenic
hypothyroidism
intrathyroid
itgdcrko
ko
micrornas
mirnas
nkx2
organization
pax8
perinatal
peroxidase
tamoxifen
tg
thyrocyte
thyrocytes
thyroglobulin
thyroid
thyroids
tpo
ttf
weights
Tagcloud (Difference)
?
adipocytes
adipogenesis
ctgdcrko
downregulated
fibrosis
follicular
goiter
goitrogenic
hypothyroidism
intrathyroid
itgdcrko
ko
micrornas
mirnas
nkx2
organization
pax8
perinatal
peroxidase
tamoxifen
tg
thyrocyte
thyrocytes
thyroglobulin
thyroid
thyroids
tpo
ttf
weights
Tagcloud (Intersection)
?