DICER1 and DHX58

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (pull down)

		DICER1	DHX58
Description		dicer 1, ribonuclease III	DExH-box helicase 58
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol RISC Complex Perinuclear Region Of Cytoplasm Extracellular Exosome RISC-loading Complex	Cytoplasm
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Helicase Activity Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Ribonuclease III Activity Deoxyribonuclease I Activity Protein Binding ATP Binding Hydrolase Activity RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Protein Domain Specific Binding SiRNA Binding Metal Ion Binding Regulatory RNA Binding Pre-miRNA Binding	Nucleotide Binding DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic DNA Fragmentation RNA Processing MiRNA Metabolic Process Negative Regulation Of Schwann Cell Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Schwann Cell Differentiation TRNA Decay Post-transcriptional Gene Silencing Nerve Development SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing Positive Regulation Of Myelination Peripheral Nervous System Myelin Formation Negative Regulation Of Tumor Necrosis Factor Production MiRNA Processing Neuron Projection Morphogenesis Regulation Of Multicellular Organismal Process RISC Complex Assembly Global Gene Silencing By MRNA Cleavage	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Virus Response To Bacterium Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Defense Response To Virus Antiviral Innate Immune Response Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway
Pathways		MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis M-decay: degradation of maternal mRNAs by maternally stored factors Regulation of MITF-M-dependent genes involved in apoptosis	DDX58/IFIH1-mediated induction of interferon-alpha/beta
Drugs
Diseases
GWAS		Body mass index ( 25760438) Body mass index (dietary energy interaction) ( 23192594) Chin dimples ( 27182965) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 28869591 30598549) Metabolite levels ( 23823483) Nose size ( 27182965) Plasma anti-thyroid peroxidase levels ( 29678681) Response to statin therapy ( 20339536)	Coronary artery disease ( 29212778) Fasting plasma glucose ( 31932636) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		12 interacting genes: AGO1 AGO2 ALOX5 DHX58 EIF2AK2 PIWIL1 PIWIL2 PIWIL4 PRKAB2 PRKRA TARBP2 TRIM25	10 interacting genes: AGO2 AP2B1 APP DHX30 DICER1 EIF2AK2 EIF6 NKRF STAU2 TRIM14
Entrez ID		23405	79132
HPRD ID		05875	13115
Ensembl ID		ENSG00000100697	ENSG00000108771
Uniprot IDs		H0YJZ6 Q9UPY3	A0AA51U9C6 Q96C10
PDB IDs		2EB1 4NGB 4NGC 4NGD 4NGF 4NGG 4NH3 4NH5 4NH6 4NHA 4WYQ 5ZAK 5ZAL 5ZAM 7XW2 7XW3	2RQA 2W4R 3EQT
Enriched GO Terms of Interacting Partners?		Double-stranded RNA Binding Regulatory NcRNA-mediated Gene Silencing RISC-loading Complex RISC Complex Assembly RNA Endonuclease Activity Pre-miRNA Processing RNA Binding Regulation Of Translation Negative Regulation Of Gene Expression MiRNA Processing PiRNA Binding SiRNA Processing Post-transcriptional Gene Silencing Single-stranded RNA Binding Post-transcriptional Regulation Of Gene Expression SiRNA Binding Antiviral Innate Immune Response PiRNA Processing P Granule RISC Complex Regulatory NcRNA-mediated Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation RNA Processing MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Secondary PiRNA Processing Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA Binding Positive Regulation Of MRNA Metabolic Process Transposable Element Silencing PiRNA-mediated Gene Silencing By MRNA Destabilization SiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Metabolic Process Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Dense Body Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Constitutive Heterochromatin Formation Protein-RNA Complex Assembly Negative Regulation Of Metabolic Process Regulation Of RNA Stability Pre-miRNA Binding Endonuclease Activity Cytoplasm Regulation Of Protein Metabolic Process	Double-stranded RNA Binding RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Protein-RNA Complex Assembly RISC-loading Complex SiRNA Processing Post-transcriptional Regulation Of Gene Expression Translational Initiation RISC Complex Assembly SiRNA Binding Protein-containing Complex Assembly Pre-miRNA Processing Protein-containing Complex Organization Post-transcriptional Gene Silencing Regulation Of Translation RNA Binding MiRNA Metabolic Process Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Translation MiRNA Processing RNA Endonuclease Activity Nucleic Acid Binding Negative Regulation Of Gene Expression Dendritic Shaft Postsynapse Translation Initiation Factor Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulatory RNA Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Biosynthetic Process Clathrin-coated Pit Positive Regulation Of Chemokine Production Regulation Of ATP Metabolic Process Ribosome Binding Negative Regulation Of Viral Process Endonuclease Activity Nucleus Translation Cellular Component Assembly Axo-dendritic Transport
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