DICER1 and PIWIL2

Number of citations of the paper that reports this interaction (PMID 12906857)
68

Data Source:
HPRD (in vivo, in vitro)

		DICER1	PIWIL2
Gene Name		dicer 1, ribonuclease type III	piwi-like RNA-mediated gene silencing 2
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol RISC Complex Axon Dendrite Growth Cone ARC Complex Micro-ribonucleoprotein Complex	Cytoplasm Polysome Chromatoid Body P Granule Pi-body
	Molecular Function	Double-stranded RNA Binding Helicase Activity Endoribonuclease Activity Ribonuclease III Activity Deoxyribonuclease I Activity Protein Binding ATP Binding MiRNA Binding Metal Ion Binding	MRNA Binding PiRNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Apoptotic DNA Fragmentation Post-embryonic Development Zygote Asymmetric Cell Division Gene Expression Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Gene Expression Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Schwann Cell Differentiation Myoblast Differentiation Involved In Skeletal Muscle Regeneration Stem Cell Maintenance Spinal Cord Motor Neuron Differentiation Nerve Development Olfactory Bulb Interneuron Differentiation Cerebral Cortex Development Lung Development Production Of SiRNA Involved In RNA Interference Targeting Of MRNA For Destruction Involved In RNA Interference Pre-miRNA Processing Hair Follicle Morphogenesis Positive Regulation Of Myelination Peripheral Nervous System Myelin Formation Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Embryonic Hindlimb Morphogenesis Production Of MiRNAs Involved In Gene Silencing By MiRNA Multicellular Organism Growth Conversion Of Ds SiRNA To Ss SiRNA Regulation Of Viral Genome Replication Regulation Of Neuron Differentiation MRNA Stabilization Spleen Development Reproductive Structure Development Regulation Of Oligodendrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis Cartilage Development Spindle Assembly Defense Response To Virus Regulation Of Cell Cycle Cardiac Muscle Cell Development Inner Ear Receptor Cell Development Intestinal Epithelial Cell Development Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Ganglion Development Regulation Of Enamel Mineralization Hair Follicle Cell Proliferation RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Positive Regulation Of MiRNA Metabolic Process	RNA 5'-end Processing Multicellular Organismal Development Spermatogenesis Gene Expression Germ-line Stem Cell Maintenance Gene Silencing By RNA PiRNA Metabolic Process DNA Methylation Involved In Gamete Generation Positive Regulation Of Translation Oogenesis Meiotic Cell Cycle Positive Regulation Of Meiosis I
Pathways		Regulatory RNA pathways MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis	PIWI-interacting RNA (piRNA) biogenesis Regulatory RNA pathways
Drugs
Diseases
GWAS		Body mass index (interaction) ( 23192594) Response to statin therapy ( 20339536)	Hypertriglyceridemia ( 23505323)
Protein-Protein Interactions		11 interactors: AGO1 AGO2 ALOX5 DHX58 EIF2AK2 PIWIL1 PIWIL2 PIWIL4 PRKAB2 PRKRA TARBP2	2 interactors: DDX4 DICER1
Entrez ID		23405	55124
HPRD ID		05875	11434
Ensembl ID		ENSG00000100697	ENSG00000197181
Uniprot IDs		Q9UPY3	Q8TC59
PDB IDs		2EB1	3O7X 3QIR
Enriched GO Terms of Interacting Partners?		Gene Silencing By RNA Gene Silencing Posttranscriptional Regulation Of Gene Expression Regulation Of Translation Regulation Of Gene Expression, Epigenetic Posttranscriptional Gene Silencing RNA Interference Negative Regulation Of Gene Expression NcRNA Metabolic Process Negative Regulation Of Defense Response To Virus PiRNA Metabolic Process Gene Silencing By MiRNA Regulation Of Cellular Protein Metabolic Process Cellular Response To DsRNA Regulation Of Protein Metabolic Process Production Of SiRNA Involved In RNA Interference Response To DsRNA Regulation Of Defense Response To Virus Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Pre-miRNA Processing Negative Regulation Of Translation RNA Metabolic Process MiRNA Metabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Gene Expression DNA Methylation Involved In Gamete Generation Cellular Response To Organic Substance RNA Processing Meiotic Cell Cycle Immune Response Regulation Of Immune System Process Nucleobase-containing Compound Metabolic Process Defense Response Response To Virus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process DNA Methylation Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Regulation Of Viral Genome Replication Evasion Or Tolerance By Virus Of Host Immune Response Leukotriene Production Involved In Inflammatory Response Regulation Of Translational Initiation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Immune System Process Cellular Response To Organic Cyclic Compound Nitrogen Compound Metabolic Process	Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Hair Follicle Cell Proliferation Conversion Of Ds SiRNA To Ss SiRNA Regulation Of Enamel Mineralization Peripheral Nervous System Myelin Formation Zygote Asymmetric Cell Division Targeting Of MRNA For Destruction Involved In RNA Interference Myoblast Differentiation Involved In Skeletal Muscle Regeneration Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Schwann Cell Proliferation NcRNA Metabolic Process Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Positive Regulation Of Schwann Cell Differentiation Asymmetric Cell Division Regulation Of Schwann Cell Differentiation Positive Regulation Of Myelination Regulation Of MiRNA Metabolic Process Production Of SiRNA Involved In RNA Interference Negative Regulation Of Glial Cell Proliferation Olfactory Bulb Interneuron Differentiation RNA Interference Pre-miRNA Processing Ganglion Development Regulation Of Odontogenesis Of Dentin-containing Tooth Intestinal Epithelial Cell Development Apoptotic DNA Fragmentation Intestinal Epithelial Cell Differentiation Production Of MiRNAs Involved In Gene Silencing By MiRNA Cell Cycle Process Skeletal Muscle Tissue Regeneration MRNA Stabilization Male Meiosis I Regulation Of Odontogenesis Apoptotic Nuclear Changes Myelin Assembly PiRNA Metabolic Process Hair Follicle Morphogenesis Gene Silencing By MiRNA Cellular Response To DsRNA Reproductive Process Positive Regulation Of Glial Cell Differentiation Posttranscriptional Gene Silencing Cell Cycle Inner Ear Receptor Cell Development Epidermis Morphogenesis Olfactory Bulb Development Spleen Development Olfactory Lobe Development Regulation Of Oligodendrocyte Differentiation Spinal Cord Motor Neuron Differentiation
Tagcloud ?		adipocytes adipogenesis ctgdcrko downregulated fibrosis follicular goiter goitrogenic hypothyroidism intrathyroid itgdcrko ko micrornas mirnas nkx2 organization pax8 perinatal peroxidase tamoxifen tg thyrocyte thyrocytes thyroglobulin thyroid thyroids tpo ttf weights	apoptosis binds fas filament finding hybrid increases indicates inhibits interacting intermediate k8 keratin p38 partner plays protecting protects represses revealing ser src stimuli supports triple tumorigenesis ubiquitin widely
Tagcloud (Difference) ?		adipocytes adipogenesis ctgdcrko downregulated fibrosis follicular goiter goitrogenic hypothyroidism intrathyroid itgdcrko ko micrornas mirnas nkx2 organization pax8 perinatal peroxidase tamoxifen tg thyrocyte thyrocytes thyroglobulin thyroid thyroids tpo ttf weights	apoptosis binds fas filament finding hybrid increases indicates inhibits interacting intermediate k8 keratin p38 partner plays protecting protects represses revealing ser src stimuli supports triple tumorigenesis ubiquitin widely
Tagcloud (Intersection) ?