DICER1 and AGO2

Number of citations of the paper that reports this interaction (PMID 12526743)
55

Data Source:
HPRD (in vivo)

		DICER1	AGO2
Gene Name		dicer 1, ribonuclease type III	argonaute RISC catalytic component 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol RISC Complex Axon Dendrite Growth Cone ARC Complex Micro-ribonucleoprotein Complex	Cytoplasmic MRNA Processing Body Nucleoplasm Cytoplasm Cytosol Polysome MRNA Cap Binding Complex Membrane RISC Complex Ribonucleoprotein Complex Micro-ribonucleoprotein Complex
	Molecular Function	Double-stranded RNA Binding Helicase Activity Endoribonuclease Activity Ribonuclease III Activity Deoxyribonuclease I Activity Protein Binding ATP Binding MiRNA Binding Metal Ion Binding	RNA 7-methylguanosine Cap Binding MRNA Binding Translation Initiation Factor Activity Endoribonuclease Activity Protein Binding SiRNA Binding MiRNA Binding Poly(A) RNA Binding Metal Ion Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Apoptotic DNA Fragmentation Post-embryonic Development Zygote Asymmetric Cell Division Gene Expression Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Gene Expression Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Schwann Cell Differentiation Myoblast Differentiation Involved In Skeletal Muscle Regeneration Stem Cell Maintenance Spinal Cord Motor Neuron Differentiation Nerve Development Olfactory Bulb Interneuron Differentiation Cerebral Cortex Development Lung Development Production Of SiRNA Involved In RNA Interference Targeting Of MRNA For Destruction Involved In RNA Interference Pre-miRNA Processing Hair Follicle Morphogenesis Positive Regulation Of Myelination Peripheral Nervous System Myelin Formation Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Embryonic Hindlimb Morphogenesis Production Of MiRNAs Involved In Gene Silencing By MiRNA Multicellular Organism Growth Conversion Of Ds SiRNA To Ss SiRNA Regulation Of Viral Genome Replication Regulation Of Neuron Differentiation MRNA Stabilization Spleen Development Reproductive Structure Development Regulation Of Oligodendrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis Cartilage Development Spindle Assembly Defense Response To Virus Regulation Of Cell Cycle Cardiac Muscle Cell Development Inner Ear Receptor Cell Development Intestinal Epithelial Cell Development Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Ganglion Development Regulation Of Enamel Mineralization Hair Follicle Cell Proliferation RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Positive Regulation Of MiRNA Metabolic Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Translation Translational Initiation Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Post-embryonic Development Gene Expression MiRNA Metabolic Process Posttranscriptional Gene Silencing Gene Silencing By RNA Pre-miRNA Processing SiRNA Loading Onto RISC Involved In RNA Interference Negative Regulation Of Translation Involved In Gene Silencing By MiRNA MRNA Cleavage Involved In Gene Silencing By MiRNA Fc-epsilon Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Translational Initiation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways		Regulatory RNA pathways MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Regulatory RNA pathways Signaling by Wnt Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Pre-NOTCH Transcription and Translation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Pre-NOTCH Expression and Processing Post-transcriptional silencing by small RNAs Innate Immune System Signaling by PDGF Transcriptional regulation by small RNAs Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 MicroRNA (miRNA) biogenesis Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR beta-catenin independent WNT signaling Signaling by ERBB2 Signaling by EGFR Ca2+ pathway Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Small interfering RNA (siRNA) biogenesis Adaptive Immune System
Drugs
Diseases
GWAS		Body mass index (interaction) ( 23192594) Response to statin therapy ( 20339536)
Protein-Protein Interactions		11 interactors: AGO1 AGO2 ALOX5 DHX58 EIF2AK2 PIWIL1 PIWIL2 PIWIL4 PRKAB2 PRKRA TARBP2	15 interactors: AGO1 BTRC DCP1A DCP2 DDX20 DHX58 DICER1 GEMIN4 MIRLET7B MIRLET7I PFKP PRKRA TARBP2 TBK1 TBKBP1
Entrez ID		23405	27161
HPRD ID		05875	06943
Ensembl ID		ENSG00000100697	ENSG00000123908
Uniprot IDs		Q9UPY3	A4FVC0 Q9UKV8
PDB IDs		2EB1	3LUC 3LUD 3LUG 3LUH 3LUJ 3LUK 3QX8 3QX9 4EI1 4EI3 4F3T
Enriched GO Terms of Interacting Partners?		Gene Silencing By RNA Gene Silencing Posttranscriptional Regulation Of Gene Expression Regulation Of Translation Regulation Of Gene Expression, Epigenetic Posttranscriptional Gene Silencing RNA Interference Negative Regulation Of Gene Expression NcRNA Metabolic Process Negative Regulation Of Defense Response To Virus PiRNA Metabolic Process Gene Silencing By MiRNA Regulation Of Cellular Protein Metabolic Process Cellular Response To DsRNA Regulation Of Protein Metabolic Process Production Of SiRNA Involved In RNA Interference Response To DsRNA Regulation Of Defense Response To Virus Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Pre-miRNA Processing Negative Regulation Of Translation RNA Metabolic Process MiRNA Metabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Gene Expression DNA Methylation Involved In Gamete Generation Cellular Response To Organic Substance RNA Processing Meiotic Cell Cycle Immune Response Regulation Of Immune System Process Nucleobase-containing Compound Metabolic Process Defense Response Response To Virus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process DNA Methylation Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Regulation Of Viral Genome Replication Evasion Or Tolerance By Virus Of Host Immune Response Leukotriene Production Involved In Inflammatory Response Regulation Of Translational Initiation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Immune System Process Cellular Response To Organic Cyclic Compound Nitrogen Compound Metabolic Process	Production Of SiRNA Involved In RNA Interference Posttranscriptional Gene Silencing RNA Interference Gene Silencing By RNA Gene Silencing Gene Silencing By MiRNA Cellular Response To DsRNA Targeting Of MRNA For Destruction Involved In RNA Interference Ribonucleoprotein Complex Assembly Negative Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression NcRNA Metabolic Process Regulation Of Gene Expression, Epigenetic Response To DsRNA MRNA Metabolic Process RNA Processing Pre-miRNA Processing Response To Virus Ribonucleoprotein Complex Biogenesis Production Of MiRNAs Involved In Gene Silencing By MiRNA Cellular Response To Organic Cyclic Compound Cellular Macromolecule Catabolic Process Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of Defense Response To Virus RNA Metabolic Process Aromatic Compound Catabolic Process MRNA Catabolic Process Defense Response To Virus Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Catabolic Process Gene Expression Catabolic Process Spliceosomal SnRNP Assembly Negative Regulation Of Type I Interferon Production Cellular Macromolecular Complex Assembly Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Immune Response Response To Other Organism Defense Response Response To Biotic Stimulus Immune System Process Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Hair Follicle Cell Proliferation Conversion Of Ds SiRNA To Ss SiRNA Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Type I Interferon Production Regulation Of Defense Response To Virus Nucleobase-containing Compound Metabolic Process
Tagcloud ?		adipocytes adipogenesis ctgdcrko downregulated fibrosis follicular goiter goitrogenic hypothyroidism intrathyroid itgdcrko ko micrornas mirnas nkx2 organization pax8 perinatal peroxidase tamoxifen tg thyrocyte thyrocytes thyroglobulin thyroid thyroids tpo ttf weights	acf acriflavine aerosol alphaviruses avenue bioterror capsid degrading downregulating encephalitic encephalitis equine equines licensed loads master nile priority publications resultant risc stomatitis titers trd veev venezuelan vesicular virulent weapon
Tagcloud (Difference) ?		adipocytes adipogenesis ctgdcrko downregulated fibrosis follicular goiter goitrogenic hypothyroidism intrathyroid itgdcrko ko micrornas mirnas nkx2 organization pax8 perinatal peroxidase tamoxifen tg thyrocyte thyrocytes thyroglobulin thyroid thyroids tpo ttf weights	acf acriflavine aerosol alphaviruses avenue bioterror capsid degrading downregulating encephalitic encephalitis equine equines licensed loads master nile priority publications resultant risc stomatitis titers trd veev venezuelan vesicular virulent weapon
Tagcloud (Intersection) ?