DICER1 and EIF2AK2

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		DICER1	EIF2AK2
Gene Name		dicer 1, ribonuclease type III	eukaryotic translation initiation factor 2-alpha kinase 2
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol RISC Complex Axon Dendrite Growth Cone ARC Complex Micro-ribonucleoprotein Complex	Nucleus Cytoplasm Cytosol Ribosome Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Double-stranded RNA Binding Helicase Activity Endoribonuclease Activity Ribonuclease III Activity Deoxyribonuclease I Activity Protein Binding ATP Binding MiRNA Binding Metal Ion Binding	Double-stranded RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Type 2A Regulator Activity Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Apoptotic DNA Fragmentation Post-embryonic Development Zygote Asymmetric Cell Division Gene Expression Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Gene Expression Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Schwann Cell Differentiation Myoblast Differentiation Involved In Skeletal Muscle Regeneration Stem Cell Maintenance Spinal Cord Motor Neuron Differentiation Nerve Development Olfactory Bulb Interneuron Differentiation Cerebral Cortex Development Lung Development Production Of SiRNA Involved In RNA Interference Targeting Of MRNA For Destruction Involved In RNA Interference Pre-miRNA Processing Hair Follicle Morphogenesis Positive Regulation Of Myelination Peripheral Nervous System Myelin Formation Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Embryonic Hindlimb Morphogenesis Production Of MiRNAs Involved In Gene Silencing By MiRNA Multicellular Organism Growth Conversion Of Ds SiRNA To Ss SiRNA Regulation Of Viral Genome Replication Regulation Of Neuron Differentiation MRNA Stabilization Spleen Development Reproductive Structure Development Regulation Of Oligodendrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis Cartilage Development Spindle Assembly Defense Response To Virus Regulation Of Cell Cycle Cardiac Muscle Cell Development Inner Ear Receptor Cell Development Intestinal Epithelial Cell Development Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Ganglion Development Regulation Of Enamel Mineralization Hair Follicle Cell Proliferation RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Positive Regulation Of MiRNA Metabolic Process	Activation Of MAPKK Activity Positive Regulation Of Cytokine Production Transcription, DNA-templated Translation Protein Phosphorylation Negative Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Translation Peptidyl-tyrosine Phosphorylation Modulation By Virus Of Host Morphology Or Physiology Modulation By Virus Of Host Process Viral Life Cycle Evasion Or Tolerance By Virus Of Host Immune Response Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Chemokine Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Response To Interferon-alpha Negative Regulation Of Apoptotic Process Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		Regulatory RNA pathways MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis	ISG15 antiviral mechanism Interferon Signaling Inhibition of PKR Cytokine Signaling in Immune system Host Interactions with Influenza Factors Influenza Infection NS1 Mediated Effects on Host Pathways Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS		Body mass index (interaction) ( 23192594) Response to statin therapy ( 20339536)
Protein-Protein Interactions		11 interactors: AGO1 AGO2 ALOX5 DHX58 EIF2AK2 PIWIL1 PIWIL2 PIWIL4 PRKAB2 PRKRA TARBP2	48 interactors: CASP3 CASP7 CASP8 CDC42 CHUK DHX30 DHX58 DHX9 DICER1 DNAJC3 EDC4 EIF2S1 EIF6 ELF2 FTSJ3 HIST2H2AC HSP90AA1 HSPA1A IKBKB IL7R ILF2 ILF3 JAK1 MAP3K5 MAP3K7 METAP2 MOV10 NFKBIA NPM1 PDGFRB PPP1CA PPP1CC PPP2R5A PRKRA PRKRIP1 PRKRIR PTGES3 RAC1 STAT1 STAT3 STRBP TAB2 TARBP2 TIRAP TOLLIP TP53 TYK2 ZNF346
Entrez ID		23405	5610
HPRD ID		05875	01468
Ensembl ID		ENSG00000100697	ENSG00000055332
Uniprot IDs		Q9UPY3	B7ZKK7 P19525 Q8IW76
PDB IDs		2EB1	1QU6 2A19 2A1A 3UIU
Enriched GO Terms of Interacting Partners?		Gene Silencing By RNA Gene Silencing Posttranscriptional Regulation Of Gene Expression Regulation Of Translation Regulation Of Gene Expression, Epigenetic Posttranscriptional Gene Silencing RNA Interference Negative Regulation Of Gene Expression NcRNA Metabolic Process Negative Regulation Of Defense Response To Virus PiRNA Metabolic Process Gene Silencing By MiRNA Regulation Of Cellular Protein Metabolic Process Cellular Response To DsRNA Regulation Of Protein Metabolic Process Production Of SiRNA Involved In RNA Interference Response To DsRNA Regulation Of Defense Response To Virus Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Pre-miRNA Processing Negative Regulation Of Translation RNA Metabolic Process MiRNA Metabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Gene Expression DNA Methylation Involved In Gamete Generation Cellular Response To Organic Substance RNA Processing Meiotic Cell Cycle Immune Response Regulation Of Immune System Process Nucleobase-containing Compound Metabolic Process Defense Response Response To Virus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process DNA Methylation Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Regulation Of Viral Genome Replication Evasion Or Tolerance By Virus Of Host Immune Response Leukotriene Production Involved In Inflammatory Response Regulation Of Translational Initiation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Immune System Process Cellular Response To Organic Cyclic Compound Nitrogen Compound Metabolic Process	Immune Response Defense Response Immune System Process Innate Immune Response Response To Stress Response To Organic Substance Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Immune System Process Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process Response To Stimulus Regulation Of Cell Death Response To External Stimulus Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Stimulus Regulation Of Apoptotic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Fc Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Signal Transduction Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Posttranscriptional Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Response To Biotic Stimulus Response To Abiotic Stimulus Signaling Response To Growth Factor Response To Virus Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Kinase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Metabolic Process Response To DsRNA Positive Regulation Of Intracellular Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway
Tagcloud ?		adipocytes adipogenesis ctgdcrko downregulated fibrosis follicular goiter goitrogenic hypothyroidism intrathyroid itgdcrko ko micrornas mirnas nkx2 organization pax8 perinatal peroxidase tamoxifen tg thyrocyte thyrocytes thyroglobulin thyroid thyroids tpo ttf weights	c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x
Tagcloud (Difference) ?		adipocytes adipogenesis ctgdcrko downregulated fibrosis follicular goiter goitrogenic hypothyroidism intrathyroid itgdcrko ko micrornas mirnas nkx2 organization pax8 perinatal peroxidase tamoxifen tg thyrocyte thyrocytes thyroglobulin thyroid thyroids tpo ttf weights	c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1 tbl1x
Tagcloud (Intersection) ?