DICER1 and TARBP2

Number of citations of the paper that reports this interaction (PMID 15973356)
419

Data Source:
HPRD (in vivo, in vitro)

		DICER1	TARBP2
Gene Name		dicer 1, ribonuclease type III	TAR (HIV-1) RNA binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol RISC Complex Axon Dendrite Growth Cone ARC Complex Micro-ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol RISC Complex Micro-ribonucleoprotein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Double-stranded RNA Binding Helicase Activity Endoribonuclease Activity Ribonuclease III Activity Deoxyribonuclease I Activity Protein Binding ATP Binding MiRNA Binding Metal Ion Binding	Double-stranded RNA Binding Protein Binding SiRNA Binding MiRNA Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Apoptotic DNA Fragmentation Post-embryonic Development Zygote Asymmetric Cell Division Gene Expression Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Gene Expression Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Schwann Cell Differentiation Myoblast Differentiation Involved In Skeletal Muscle Regeneration Stem Cell Maintenance Spinal Cord Motor Neuron Differentiation Nerve Development Olfactory Bulb Interneuron Differentiation Cerebral Cortex Development Lung Development Production Of SiRNA Involved In RNA Interference Targeting Of MRNA For Destruction Involved In RNA Interference Pre-miRNA Processing Hair Follicle Morphogenesis Positive Regulation Of Myelination Peripheral Nervous System Myelin Formation Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Embryonic Hindlimb Morphogenesis Production Of MiRNAs Involved In Gene Silencing By MiRNA Multicellular Organism Growth Conversion Of Ds SiRNA To Ss SiRNA Regulation Of Viral Genome Replication Regulation Of Neuron Differentiation MRNA Stabilization Spleen Development Reproductive Structure Development Regulation Of Oligodendrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis Cartilage Development Spindle Assembly Defense Response To Virus Regulation Of Cell Cycle Cardiac Muscle Cell Development Inner Ear Receptor Cell Development Intestinal Epithelial Cell Development Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Ganglion Development Regulation Of Enamel Mineralization Hair Follicle Cell Proliferation RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Positive Regulation Of MiRNA Metabolic Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Translation Negative Regulation Of Protein Kinase Activity Gene Expression Production Of SiRNA Involved In RNA Interference Targeting Of MRNA For Destruction Involved In RNA Interference Pre-miRNA Processing MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Positive Regulation Of Viral Genome Replication Regulation Of Viral Transcription Negative Regulation Of Defense Response To Virus By Host
Pathways		Regulatory RNA pathways MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis	Regulatory RNA pathways MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
Drugs
Diseases
GWAS		Body mass index (interaction) ( 23192594) Response to statin therapy ( 20339536)
Protein-Protein Interactions		11 interactors: AGO1 AGO2 ALOX5 DHX58 EIF2AK2 PIWIL1 PIWIL2 PIWIL4 PRKAB2 PRKRA TARBP2	21 interactors: AGO2 APP DICER1 EIF2AK2 HDHD2 IKBKG KCNIP3 MED21 NEDD4L NEUROG1 NF2 NUDT18 PRKRA RBM14 STRBP TCEANC TGIF2 TOP1 TRAF4 VAV2 ZNF346
Entrez ID		23405	6895
HPRD ID		05875	05446
Ensembl ID		ENSG00000100697	ENSG00000139546
Uniprot IDs		Q9UPY3	Q15633
PDB IDs		2EB1	2CPN 3ADL 3LLH
Enriched GO Terms of Interacting Partners?		Gene Silencing By RNA Gene Silencing Posttranscriptional Regulation Of Gene Expression Regulation Of Translation Regulation Of Gene Expression, Epigenetic Posttranscriptional Gene Silencing RNA Interference Negative Regulation Of Gene Expression NcRNA Metabolic Process Negative Regulation Of Defense Response To Virus PiRNA Metabolic Process Gene Silencing By MiRNA Regulation Of Cellular Protein Metabolic Process Cellular Response To DsRNA Regulation Of Protein Metabolic Process Production Of SiRNA Involved In RNA Interference Response To DsRNA Regulation Of Defense Response To Virus Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Pre-miRNA Processing Negative Regulation Of Translation RNA Metabolic Process MiRNA Metabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Gene Expression DNA Methylation Involved In Gamete Generation Cellular Response To Organic Substance RNA Processing Meiotic Cell Cycle Immune Response Regulation Of Immune System Process Nucleobase-containing Compound Metabolic Process Defense Response Response To Virus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process DNA Methylation Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Regulation Of Viral Genome Replication Evasion Or Tolerance By Virus Of Host Immune Response Leukotriene Production Involved In Inflammatory Response Regulation Of Translational Initiation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Immune System Process Cellular Response To Organic Cyclic Compound Nitrogen Compound Metabolic Process	Regulation Of Gene Expression RNA Interference Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of NIK/NF-kappaB Signaling Posttranscriptional Regulation Of Gene Expression Regulation Of NIK/NF-kappaB Signaling Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Cellular Response To DsRNA Posttranscriptional Gene Silencing Positive Regulation Of Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Programmed Cell Death Regulation Of Apoptotic Process Cell Death Death Gene Silencing By RNA Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Response To DsRNA Production Of SiRNA Involved In RNA Interference Regulation Of Kinase Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Response To Virus Cellular Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Pre-miRNA Processing Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Gene Silencing Sensory Organ Development Apoptotic Process Activation Of NF-kappaB-inducing Kinase Activity Production Of MiRNAs Involved In Gene Silencing By MiRNA Multicellular Organismal Development Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Differentiation Response To Stress
Tagcloud ?		adipocytes adipogenesis ctgdcrko downregulated fibrosis follicular goiter goitrogenic hypothyroidism intrathyroid itgdcrko ko micrornas mirnas nkx2 organization pax8 perinatal peroxidase tamoxifen tg thyrocyte thyrocytes thyroglobulin thyroid thyroids tpo ttf weights	computational conducting defining deregulated destabilization destabilizes destabilizing displaying elements govern governed huntington integrating isogenic metastatic modulators overrepresented represses searches srse srses tbses termed transcriptionally transcripts unbiased uncovered unexplored znf395
Tagcloud (Difference) ?		adipocytes adipogenesis ctgdcrko downregulated fibrosis follicular goiter goitrogenic hypothyroidism intrathyroid itgdcrko ko micrornas mirnas nkx2 organization pax8 perinatal peroxidase tamoxifen tg thyrocyte thyrocytes thyroglobulin thyroid thyroids tpo ttf weights	computational conducting defining deregulated destabilization destabilizes destabilizing displaying elements govern governed huntington integrating isogenic metastatic modulators overrepresented represses searches srse srses tbses termed transcriptionally transcripts unbiased uncovered unexplored znf395
Tagcloud (Intersection) ?