DICER1 and TARBP2

Number of citations of the paper that reports this interaction (PubMedID 16424907)
60

Data Source:
HPRD (in vitro, in vivo)

		DICER1	TARBP2
Description		dicer 1, ribonuclease III	TARBP2 subunit of RISC loading complex
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol RISC Complex Perinuclear Region Of Cytoplasm Extracellular Exosome RISC-loading Complex	Nucleus Nucleoplasm Cytoplasm Cytosol RISC Complex Nuclear Body Perinuclear Region Of Cytoplasm RISC-loading Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Helicase Activity Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Ribonuclease III Activity Deoxyribonuclease I Activity Protein Binding ATP Binding Hydrolase Activity RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Protein Domain Specific Binding SiRNA Binding Metal Ion Binding Regulatory RNA Binding Pre-miRNA Binding	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Binding SiRNA Binding MiRNA Binding Pre-mRNA Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding Protein Sequestering Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic DNA Fragmentation RNA Processing MiRNA Metabolic Process Negative Regulation Of Schwann Cell Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Schwann Cell Differentiation TRNA Decay Post-transcriptional Gene Silencing Nerve Development SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing Positive Regulation Of Myelination Peripheral Nervous System Myelin Formation Negative Regulation Of Tumor Necrosis Factor Production MiRNA Processing Neuron Projection Morphogenesis Regulation Of Multicellular Organismal Process RISC Complex Assembly Global Gene Silencing By MRNA Cleavage	Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Translation Negative Regulation Of Protein Kinase Activity Spermatid Development Single Fertilization Post-transcriptional Regulation Of Gene Expression SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing MiRNA Processing Multicellular Organism Growth Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Skeletal Muscle Tissue Regeneration Positive Regulation Of Viral Genome Replication Positive Regulation Of Translation Regulation Of Viral Transcription Negative Regulation Of Defense Response To Virus By Host Positive Regulation Of Muscle Cell Differentiation Regulation Of Protein Metabolic Process Neural Precursor Cell Proliferation Protein K63-linked Ubiquitination Regulation Of Regulatory NcRNA Processing Regulation Of SiRNA Processing RISC Complex Assembly Global Gene Silencing By MRNA Cleavage Regulation Of MiRNA Processing
Pathways		MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis M-decay: degradation of maternal mRNAs by maternally stored factors Regulation of MITF-M-dependent genes involved in apoptosis	MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis PKR-mediated signaling
Drugs
Diseases
GWAS		Body mass index ( 25760438) Body mass index (dietary energy interaction) ( 23192594) Chin dimples ( 27182965) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 28869591 30598549) Metabolite levels ( 23823483) Nose size ( 27182965) Plasma anti-thyroid peroxidase levels ( 29678681) Response to statin therapy ( 20339536)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		12 interacting genes: AGO1 AGO2 ALOX5 DHX58 EIF2AK2 PIWIL1 PIWIL2 PIWIL4 PRKAB2 PRKRA TARBP2 TRIM25	32 interacting genes: ADARB1 AGO2 APP CDK9 DICER1 EIF2AK2 FOXP1 HDHD2 HSPB1 IKBKG KCNIP3 MAPK8IP2 MED21 NEDD4L NEUROG1 NF2 NKRF NUDT18 OGT PNKP PRKRA RBM14 RNF10 TCEA2 TCEANC TGIF2 TOP1 TRAF4 VAV2 ZMAT3 ZMAT4 ZNF346
Entrez ID		23405	6895
HPRD ID		05875	05446
Ensembl ID		ENSG00000100697	ENSG00000139546
Uniprot IDs		H0YJZ6 Q9UPY3	Q15633
PDB IDs		2EB1 4NGB 4NGC 4NGD 4NGF 4NGG 4NH3 4NH5 4NH6 4NHA 4WYQ 5ZAK 5ZAL 5ZAM 7XW2 7XW3	2CPN 3ADL 3LLH 4WYQ 5N8L 5N8M 5ZAK 5ZAL 5ZAM 6ZBK
Enriched GO Terms of Interacting Partners?		Double-stranded RNA Binding Regulatory NcRNA-mediated Gene Silencing RISC-loading Complex RISC Complex Assembly RNA Endonuclease Activity Pre-miRNA Processing RNA Binding Regulation Of Translation Negative Regulation Of Gene Expression MiRNA Processing PiRNA Binding SiRNA Processing Post-transcriptional Gene Silencing Single-stranded RNA Binding Post-transcriptional Regulation Of Gene Expression SiRNA Binding Antiviral Innate Immune Response PiRNA Processing P Granule RISC Complex Regulatory NcRNA-mediated Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation RNA Processing MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Secondary PiRNA Processing Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA Binding Positive Regulation Of MRNA Metabolic Process Transposable Element Silencing PiRNA-mediated Gene Silencing By MRNA Destabilization SiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Metabolic Process Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Dense Body Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Constitutive Heterochromatin Formation Protein-RNA Complex Assembly Negative Regulation Of Metabolic Process Regulation Of RNA Stability Pre-miRNA Binding Endonuclease Activity Cytoplasm Regulation Of Protein Metabolic Process	Double-stranded RNA Binding Nucleus Negative Regulation Of Schwann Cell Proliferation RISC-loading Complex SiRNA Processing RISC Complex Assembly SiRNA Binding Regulation Of Primary Metabolic Process Pre-miRNA Processing Regulation Of Macromolecule Metabolic Process Negative Regulation Of Glial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Nucleic Acid Binding Regulation Of Metabolic Process RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm MiRNA Processing Cell Death Programmed Cell Death Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Translational Initiation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Defense Response To Symbiont Regulation Of RNA Metabolic Process Regulation Of Nervous System Process Defense Response To Other Organism RNA Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Pre-miRNA Binding Response To External Biotic Stimulus Regulation Of Macromolecule Biosynthetic Process Defense Response Innate Immune Response Response To Other Organism Apoptotic Process Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Metabolic Process Regulation Of Tumor Necrosis Factor Production Nucleolus Regulation Of Programmed Cell Death Endonuclease Activity Regulation Of Developmental Process Response To Stress Negative Regulation Of Cell Population Proliferation Regulation Of Cell Migration
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