DICER1 and AGO1

Number of citations of the paper that reports this interaction (PMID 12526743)
55

Data Source:
HPRD (in vivo)

		DICER1	AGO1
Gene Name		dicer 1, ribonuclease type III	argonaute RISC catalytic component 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol RISC Complex Axon Dendrite Growth Cone ARC Complex Micro-ribonucleoprotein Complex	Cytoplasmic MRNA Processing Body Nucleoplasm Cytoplasm Cytosol Polysome Ribonucleoprotein Complex Micro-ribonucleoprotein Complex
	Molecular Function	Double-stranded RNA Binding Helicase Activity Endoribonuclease Activity Ribonuclease III Activity Deoxyribonuclease I Activity Protein Binding ATP Binding MiRNA Binding Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Binding Endoribonuclease Activity Protein Binding MiRNA Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Apoptotic DNA Fragmentation Post-embryonic Development Zygote Asymmetric Cell Division Gene Expression Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Gene Expression Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Schwann Cell Differentiation Myoblast Differentiation Involved In Skeletal Muscle Regeneration Stem Cell Maintenance Spinal Cord Motor Neuron Differentiation Nerve Development Olfactory Bulb Interneuron Differentiation Cerebral Cortex Development Lung Development Production Of SiRNA Involved In RNA Interference Targeting Of MRNA For Destruction Involved In RNA Interference Pre-miRNA Processing Hair Follicle Morphogenesis Positive Regulation Of Myelination Peripheral Nervous System Myelin Formation Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Embryonic Hindlimb Morphogenesis Production Of MiRNAs Involved In Gene Silencing By MiRNA Multicellular Organism Growth Conversion Of Ds SiRNA To Ss SiRNA Regulation Of Viral Genome Replication Regulation Of Neuron Differentiation MRNA Stabilization Spleen Development Reproductive Structure Development Regulation Of Oligodendrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis Cartilage Development Spindle Assembly Defense Response To Virus Regulation Of Cell Cycle Cardiac Muscle Cell Development Inner Ear Receptor Cell Development Intestinal Epithelial Cell Development Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Ganglion Development Regulation Of Enamel Mineralization Hair Follicle Cell Proliferation RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Positive Regulation Of MiRNA Metabolic Process	Nuclear-transcribed MRNA Catabolic Process Transcription, DNA-templated Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression MiRNA Metabolic Process Posttranscriptional Gene Silencing Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Fc-epsilon Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling
Pathways		Regulatory RNA pathways MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Regulatory RNA pathways Cellular Senescence Signaling by Wnt Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade Pre-NOTCH Transcription and Translation Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by NOTCH MicroRNA (miRNA) biogenesis Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System PIP3 activates AKT signaling Oncogene Induced Senescence PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Pre-NOTCH Expression and Processing Post-transcriptional silencing by small RNAs Innate Immune System Transcriptional regulation by small RNAs Signalling by NGF Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by FGFR Ca2+ pathway Oxidative Stress Induced Senescence Small interfering RNA (siRNA) biogenesis
Drugs
Diseases
GWAS		Body mass index (interaction) ( 23192594) Response to statin therapy ( 20339536)
Protein-Protein Interactions		11 interactors: AGO1 AGO2 ALOX5 DHX58 EIF2AK2 PIWIL1 PIWIL2 PIWIL4 PRKAB2 PRKRA TARBP2	7 interactors: AGO2 DCP1A DCP2 DICER1 KHDRBS1 PRNP RELA
Entrez ID		23405	26523
HPRD ID		05875	06942
Ensembl ID		ENSG00000100697	ENSG00000092847
Uniprot IDs		Q9UPY3	Q5TA58 Q9UL18
PDB IDs		2EB1	1SI2 1SI3 4KRE 4KRF 4KXT
Enriched GO Terms of Interacting Partners?		Gene Silencing By RNA Gene Silencing Posttranscriptional Regulation Of Gene Expression Regulation Of Translation Regulation Of Gene Expression, Epigenetic Posttranscriptional Gene Silencing RNA Interference Negative Regulation Of Gene Expression NcRNA Metabolic Process Negative Regulation Of Defense Response To Virus PiRNA Metabolic Process Gene Silencing By MiRNA Regulation Of Cellular Protein Metabolic Process Cellular Response To DsRNA Regulation Of Protein Metabolic Process Production Of SiRNA Involved In RNA Interference Response To DsRNA Regulation Of Defense Response To Virus Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Pre-miRNA Processing Negative Regulation Of Translation RNA Metabolic Process MiRNA Metabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Gene Expression DNA Methylation Involved In Gamete Generation Cellular Response To Organic Substance RNA Processing Meiotic Cell Cycle Immune Response Regulation Of Immune System Process Nucleobase-containing Compound Metabolic Process Defense Response Response To Virus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process DNA Methylation Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Regulation Of Viral Genome Replication Evasion Or Tolerance By Virus Of Host Immune Response Leukotriene Production Involved In Inflammatory Response Regulation Of Translational Initiation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Immune System Process Cellular Response To Organic Cyclic Compound Nitrogen Compound Metabolic Process	Positive Regulation Of Schwann Cell Differentiation Regulation Of Schwann Cell Differentiation Positive Regulation Of MiRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis Regulation Of MiRNA Metabolic Process RNA Interference Pre-miRNA Processing MRNA Metabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Metabolic Process Gene Silencing By MiRNA Positive Regulation Of Glial Cell Differentiation Cellular Response To DsRNA Posttranscriptional Gene Silencing Gene Expression Nucleic Acid Phosphodiester Bond Hydrolysis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Gliogenesis Negative Regulation Of Cellular Metabolic Process Gene Silencing By RNA Cellular Response To Organic Cyclic Compound RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Regulation Of Translational Initiation Regulation Of Glial Cell Differentiation Response To DsRNA Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Hair Follicle Cell Proliferation Acetaldehyde Metabolic Process Conversion Of Ds SiRNA To Ss SiRNA Nucleobase-containing Compound Metabolic Process Hair Follicle Development Hair Cycle Process Negative Regulation Of Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Gliogenesis Gene Silencing Heterocycle Metabolic Process Hair Cycle Cellular Aromatic Compound Metabolic Process RNA Processing Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression MRNA Cleavage Involved In Gene Silencing By MiRNA Regulation Of Enamel Mineralization Peripheral Nervous System Myelin Formation
Tagcloud ?		adipocytes adipogenesis ctgdcrko downregulated fibrosis follicular goiter goitrogenic hypothyroidism intrathyroid itgdcrko ko micrornas mirnas nkx2 organization pax8 perinatal peroxidase tamoxifen tg thyrocyte thyrocytes thyroglobulin thyroid thyroids tpo ttf weights	argonaute cassette chip clusters constitutive crossing deep elongation enhancer enhancers exon explaining implication inclusion intergenic intragenic intronic microrna overlapping paradoxically prominent rather rnai rnas seq sirnas splicing syne2 unexpectedly
Tagcloud (Difference) ?		adipocytes adipogenesis ctgdcrko downregulated fibrosis follicular goiter goitrogenic hypothyroidism intrathyroid itgdcrko ko micrornas mirnas nkx2 organization pax8 perinatal peroxidase tamoxifen tg thyrocyte thyrocytes thyroglobulin thyroid thyroids tpo ttf weights	argonaute cassette chip clusters constitutive crossing deep elongation enhancer enhancers exon explaining implication inclusion intergenic intragenic intronic microrna overlapping paradoxically prominent rather rnai rnas seq sirnas splicing syne2 unexpectedly
Tagcloud (Intersection) ?