HSPG2 and CCN2

Number of citations of the paper that reports this interaction (PubMedID 12811819)
0

Data Source:
HPRD (in vivo)

		HSPG2	CCN2
Description		heparan sulfate proteoglycan 2	cellular communication network factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Extracellular Matrix Neuron Projection Lysosomal Lumen Extracellular Exosome Plasma Membrane Protein Complex	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane Extracellular Matrix Cell Periphery
	Molecular Function	Amyloid-beta Binding Integrin Binding Calcium Ion Binding Protein Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Collagen V Binding	Integrin Binding Protein Binding Insulin-like Growth Factor Binding Heparin Binding
	Biological Process	Angiogenesis Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Lipid Metabolic Process Receptor-mediated Endocytosis Inflammatory Response Negative Regulation Of Cell Adhesion Smoothened Signaling Pathway Brain Development Embryo Implantation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Negative Regulation Of Angiogenesis Cell Differentiation Animal Organ Regeneration Negative Regulation Of Neuron Apoptotic Process Circulatory System Development Negative Regulation Of Amyloid Fibril Formation	Cartilage Condensation Ossification Angiogenesis Osteoblast Differentiation Tissue Homeostasis Chondrocyte Differentiation Cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Negative Regulation Of Gene Expression Cell Migration Lung Development Regulation Of Chondrocyte Differentiation Chondrocyte Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of JNK Cascade Regulation Of Developmental Process Positive Regulation Of Stress Fiber Assembly Connective Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade DNA Biosynthetic Process Reactive Oxygen Species Metabolic Process
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Non-integrin membrane-ECM interactions ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Amyloid fiber formation Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Formation of the dystrophin-glycoprotein complex (DGC)	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription
Drugs		Palifermin
Diseases		Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Atrial fibrillation ( 30061737) Cerebral microbleeds (lobar) ( 32913026) Height ( 28552196) PR interval ( 32439900)
Interacting Genes		33 interacting genes: APP ATF7IP ATN1 BMP1 CACNA1A CCN2 COL13A1 ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN HSP90AA1 ITGA2 ITGB1 LAMA1 MTDH NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TCAP TTR UBC VWA1	15 interacting genes: ACTB AP3D1 CCN3 ERBB4 FBLN1 HSPG2 LIMS1 LRP1 MMP14 MTDH RSPH1 TGFB1 TGFB2 TGFB3 VEGFA
Entrez ID		3339	1490
HPRD ID		00804	00412
Ensembl ID		ENSG00000142798	ENSG00000118523
Uniprot IDs		P98160	P29279 Q5M8T4
PDB IDs		3SH4 3SH5
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Structural Constituent Extracellular Matrix Extracellular Region Extracellular Space Basement Membrane Heparin Binding Collagen Binding Positive Regulation Of Cell Migration Integrin Binding Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Cell-matrix Adhesion Regulation Of Cell Motility Regulation Of Locomotion Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Platelet Alpha Granule Lumen Regulation Of Endothelial Cell Proliferation Chemoattractant Activity Growth Factor Activity Peptidase Activator Activity Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Endoplasmic Reticulum Lumen Integrin-mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Positive Chemotaxis Positive Regulation Of Cell Communication Positive Regulation Of Epithelial Cell Proliferation Response To Wounding Positive Regulation Of Endothelial Cell Migration Cell Adhesion Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Developmental Process Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Animal Organ Development	Extracellular Matrix Regulation Of SMAD Protein Signal Transduction Type III Transforming Growth Factor Beta Receptor Binding Regulation Of Cell Adhesion Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Regulation Of Protein Localization Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Type II Transforming Growth Factor Beta Receptor Binding Salivary Gland Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Adhesion Response To Hypoxia Negative Regulation Of Macrophage Cytokine Production Regulation Of Cell Population Proliferation Response To Decreased Oxygen Levels Growth Factor Activity Response To Growth Factor Positive Regulation Of Cell Differentiation Response To Oxygen Levels Transforming Growth Factor Beta Receptor Binding Platelet Alpha Granule Lumen Positive Regulation Of Cell Population Proliferation Cell-cell Junction Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Regulation Of Epithelial Cell Proliferation Regulation Of Cell Migration Regulation Of Multicellular Organismal Development Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Motility Uterine Wall Breakdown Extracellular Space Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Biosynthetic Process Regulation Of Locomotion Positive Regulation Of Cell Division Positive Regulation Of Metabolic Process Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Localization Cell Junction Organization Gland Morphogenesis Face Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Protein Localization To Plasma Membrane
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