HSPG2 and TTR

Number of citations of the paper that reports this interaction (PMID 9307034)
2

Data Source:
HPRD (in vivo, in vitro)

		HSPG2	TTR
Gene Name		heparan sulfate proteoglycan 2	transthyretin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Basal Lamina Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Extracellular Matrix Lysosomal Lumen Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Cytoplasm Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Metal Ion Binding	Hormone Activity Protein Binding Identical Protein Binding Protein Heterodimerization Activity Thyroid Hormone Binding
	Biological Process	Retinoid Metabolic Process Angiogenesis Endochondral Ossification Chondrocyte Differentiation Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Brain Development Phototransduction, Visible Light Protein Localization Pathogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Lipoprotein Metabolic Process Small Molecule Metabolic Process Embryonic Skeletal System Morphogenesis Cardiac Muscle Tissue Development Cartilage Development Involved In Endochondral Bone Morphogenesis	Retinoid Metabolic Process Transport Phototransduction, Visible Light Extracellular Matrix Organization Retinol Metabolic Process Thyroid Hormone Transport
Pathways		Lipoprotein metabolism Metabolism of lipids and lipoproteins MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Degradation of the extracellular matrix Amyloids Defective CHST14 causes EDS, musculocontractural type Laminin interactions Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Glycogen storage diseases Defective CHST6 causes MCDC1 Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 Diseases associated with visual transduction MPS IV - Morquio syndrome A Integrin cell surface interactions Metabolism of carbohydrates HS-GAG biosynthesis MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type Chylomicron-mediated lipid transport Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Lipid digestion, mobilization, and transport Non-integrin membrane-ECM interactions Defective EXT1 causes exostoses 1, TRPS2 and CHDS Visual phototransduction Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome HS-GAG degradation	Amyloids Visual phototransduction The canonical retinoid cycle in rods (twilight vision) Retinoid cycle disease events Non-integrin membrane-ECM interactions Diseases associated with visual transduction Retinoid metabolism and transport
Drugs		Palifermin
Diseases
GWAS			Retinol levels ( 21878437)
Protein-Protein Interactions		29 interactors: APP ATF7IP ATN1 BMP1 CACNA1A COL13A1 CTGF ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN ITGA2 ITGB1 LAMA1 NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TTR VWA1	46 interactors: A2M ACTB AGER APOA1 ASNA1 ATF4 BAG6 C14orf1 CDR2 CHD3 CLU CPNE6 CTNND2 DDR1 EEF1A1 FEZ1 GET4 HNRNPH3 HSPG2 IKBKAP INPP5K KIAA1377 LRP2 MARK3 MT3 NECAB2 NGFR OTUB1 PHYHIP PIK3R1 PRKCI QARS RAI1 RBP4 RNF115 SDF4 SETDB1 SP110 ST13 ST3GAL3 SUMO3 TAF1C TAF5L TUBA1A VIM ZBED1
Entrez ID		3339	7276
HPRD ID		00804	01447
Ensembl ID		ENSG00000142798	ENSG00000118271
Uniprot IDs		P98160	E9KL36 P02766
PDB IDs		3SH4 3SH5	1BM7 1BMZ 1BZ8 1BZD 1BZE 1DVQ 1DVS 1DVT 1DVU 1DVX 1DVY 1DVZ 1E3F 1E4H 1E5A 1ETA 1ETB 1F41 1F64 1F86 1FH2 1FHN 1G1O 1GKO 1ICT 1III 1IIK 1IJN 1QAB 1QWH 1RLB 1SOK 1SOQ 1THA 1THC 1TLM 1TSH 1TT6 1TTA 1TTB 1TTC 1TTR 1TYR 1TZ8 1U21 1X7S 1X7T 1Y1D 1Z7J 1ZCR 1ZD6 2B14 2B15 2B16 2B77 2B9A 2F7I 2F8I 2FBR 2FLM 2G3X 2G3Z 2G4E 2G4G 2G5U 2G9K 2GAB 2H4E 2M5N 2NOY 2PAB 2QEL 2QGB 2QGC 2QGD 2QGE 2ROX 2ROY 2TRH 2TRY 2WQA 3A4D 3A4E 3A4F 3B56 3BSZ 3BT0 3CBR 3CFM 3CFN 3CFQ 3CFT 3CN0 3CN1 3CN2 3CN3 3CN4 3CXF 3D2T 3D7P 3DGD 3DID 3DJR 3DJS 3DJT 3DJZ 3DK0 3DK2 3DO4 3ESN 3ESO 3ESP 3FC8 3FCB 3GLZ 3GPS 3GRB 3GRG 3GS0 3GS4 3GS7 3HJ0 3I9A 3I9I 3I9P 3IMR 3IMS 3IMT 3IMU 3IMV 3IMW 3IPB 3IPE 3KGS 3KGT 3KGU 3M1O 3NEE 3NEO 3NES 3NEX 3NG5 3OZK 3OZL 3P3R 3P3S 3P3T 3P3U 3SSG 3TCT 3TFB 3U2I 3U2J 3W3B 4ABQ 4ABU 4ABV 4ABW 4AC2 4AC4 4ACT 4ANK 4DER 4DES 4DET 4DEU 4DEW 4FI6 4FI7 4FI8 4HIQ 4HIS 4I85 4I87 4I89 4IIZ 4IK6 4IK7 4IKI 4IKJ 4IKK 4IKL 4KY2 4L1S 4L1T 4MAS 5TTR
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Multicellular Organismal Development Cell-matrix Adhesion System Development Developmental Process Anatomical Structure Development Cell-substrate Adhesion Response To Wounding Organ Development Locomotion Regulation Of Cell Migration Positive Regulation Of Cell Proliferation Platelet Degranulation Blood Vessel Morphogenesis Regulation Of Cell Motility Cardiovascular System Development Positive Regulation Of Epithelial Cell Migration Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Extracellular Matrix Disassembly Positive Regulation Of Cell Motility Blood Vessel Development Secretion By Cell Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Vasculature Development Anatomical Structure Morphogenesis Response To Growth Factor Wound Healing Positive Regulation Of Cellular Protein Metabolic Process Chemotaxis Regulation Of Cell Proliferation Blood Coagulation Secretion Hemostasis Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Epithelial Cell Proliferation Regulation Of Cellular Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol Biosynthetic Process Organ Morphogenesis Angiogenesis Tissue Development Exocytosis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor	Protein Insertion Into ER Membrane Anatomical Structure Development Developmental Process Protein Stabilization Protein Metabolic Process Cellular Protein Metabolic Process Multicellular Organismal Development Regulation Of Protein Stability Nervous System Development Central Nervous System Development Regulation Of Gene Expression Protein Insertion Into Membrane System Development Cellular Localization Phototransduction, Visible Light Retinoid Metabolic Process Detection Of Abiotic Stimulus Diterpenoid Metabolic Process Detection Of Visible Light Cellular Response To Stimulus Platelet Activation Phototransduction Response To Light Stimulus Chromatin Organization Regulation Of Glucose Transport Alcohol Metabolic Process Detection Of Light Stimulus Organelle Organization Establishment Of Protein Localization To Membrane Metabolic Process Lipid Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Metabolic Process Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Cellular Metabolic Process Isoprenoid Metabolic Process Response To Organic Substance Endoplasmic Reticulum Organization Chromatin Modification Regulation Of Cellular Protein Metabolic Process Membrane Organization Response To Radiation Negative Regulation Of Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Response To Wounding Signaling Regulation Of Glucose Import Cellular Protein Modification Process
Tagcloud ?		akathisia bradykinesia drd3 drd4 dyskinesia dystonia fluctuating grin2a grin2b htr2c naturalistic nominal orofacial parkinsonism preferably rater rs10772715 rs11644461 rs11866328 rs1345423 rs1650420 rs2192970 rs324035 rs4911871 rs7192557 tardive td tremor truncal	arteriovenous carotid clamped conscious constant cooled cooling degree depend destined driving extrahypothalamic gain goats hypothalamic hypothalamus loops manipulate passage rete sbc shunt tbr temperatures termed texh thermodes thyp trunk
Tagcloud (Difference) ?		akathisia bradykinesia drd3 drd4 dyskinesia dystonia fluctuating grin2a grin2b htr2c naturalistic nominal orofacial parkinsonism preferably rater rs10772715 rs11644461 rs11866328 rs1345423 rs1650420 rs2192970 rs324035 rs4911871 rs7192557 tardive td tremor truncal	arteriovenous carotid clamped conscious constant cooled cooling degree depend destined driving extrahypothalamic gain goats hypothalamic hypothalamus loops manipulate passage rete sbc shunt tbr temperatures termed texh thermodes thyp trunk
Tagcloud (Intersection) ?