HSPG2 and SPARC

Number of citations of the paper that reports this interaction (PMID 2745554)
60

Data Source:
HPRD (in vitro)

		HSPG2	SPARC
Gene Name		heparan sulfate proteoglycan 2	secreted protein, acidic, cysteine-rich (osteonectin)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Basal Lamina Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Extracellular Matrix Lysosomal Lumen Extracellular Vesicular Exosome	Extracellular Region Basement Membrane Extracellular Space Cytoplasm Mitochondrion Plasma Membrane Cell Surface Nuclear Matrix Platelet Alpha Granule Platelet Alpha Granule Membrane Platelet Alpha Granule Lumen Endocytic Vesicle Lumen
	Molecular Function	Protein Binding Protein C-terminus Binding Metal Ion Binding	Calcium Ion Binding Protein Binding Collagen Binding Extracellular Matrix Binding
	Biological Process	Retinoid Metabolic Process Angiogenesis Endochondral Ossification Chondrocyte Differentiation Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Brain Development Phototransduction, Visible Light Protein Localization Pathogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Lipoprotein Metabolic Process Small Molecule Metabolic Process Embryonic Skeletal System Morphogenesis Cardiac Muscle Tissue Development Cartilage Development Involved In Endochondral Bone Morphogenesis	Ossification Negative Regulation Of Endothelial Cell Proliferation Platelet Degranulation Receptor-mediated Endocytosis Signal Transduction Heart Development Blood Coagulation Response To Gravity Response To Lead Ion Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Cell Morphogenesis Platelet Activation Extracellular Matrix Organization Lung Development Response To Lipopolysaccharide Response To L-ascorbic Acid Response To Cytokine Response To Peptide Hormone Response To Ethanol Response To Cadmium Ion Inner Ear Development Response To Glucocorticoid Response To CAMP Response To Calcium Ion Bone Development Cellular Response To Growth Factor Stimulus
Pathways		Lipoprotein metabolism Metabolism of lipids and lipoproteins MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Degradation of the extracellular matrix Amyloids Defective CHST14 causes EDS, musculocontractural type Laminin interactions Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Glycogen storage diseases Defective CHST6 causes MCDC1 Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 Diseases associated with visual transduction MPS IV - Morquio syndrome A Integrin cell surface interactions Metabolism of carbohydrates HS-GAG biosynthesis MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type Chylomicron-mediated lipid transport Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Lipid digestion, mobilization, and transport Non-integrin membrane-ECM interactions Defective EXT1 causes exostoses 1, TRPS2 and CHDS Visual phototransduction Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome HS-GAG degradation	Scavenging by Class H Receptors Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Platelet degranulation Platelet activation, signaling and aggregation
Drugs		Palifermin
Diseases
GWAS
Protein-Protein Interactions		29 interactors: APP ATF7IP ATN1 BMP1 CACNA1A COL13A1 CTGF ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN ITGA2 ITGB1 LAMA1 NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TTR VWA1	21 interactors: COL13A1 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 CTSK FN1 HSPG2 PDGFA PDGFB PLAT PLG SDC2 TGFB1 TGM2 THBS1 UBQLN1 VEGFA XRCC6 ZNF579
Entrez ID		3339	6678
HPRD ID		00804	01631
Ensembl ID		ENSG00000142798	ENSG00000113140
Uniprot IDs		P98160	P09486
PDB IDs		3SH4 3SH5	1BMO 1NUB 1SRA 2V53
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Multicellular Organismal Development Cell-matrix Adhesion System Development Developmental Process Anatomical Structure Development Cell-substrate Adhesion Response To Wounding Organ Development Locomotion Regulation Of Cell Migration Positive Regulation Of Cell Proliferation Platelet Degranulation Blood Vessel Morphogenesis Regulation Of Cell Motility Cardiovascular System Development Positive Regulation Of Epithelial Cell Migration Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Extracellular Matrix Disassembly Positive Regulation Of Cell Motility Blood Vessel Development Secretion By Cell Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Vasculature Development Anatomical Structure Morphogenesis Response To Growth Factor Wound Healing Positive Regulation Of Cellular Protein Metabolic Process Chemotaxis Regulation Of Cell Proliferation Blood Coagulation Secretion Hemostasis Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Epithelial Cell Proliferation Regulation Of Cellular Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol Biosynthetic Process Organ Morphogenesis Angiogenesis Tissue Development Exocytosis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Wound Healing Platelet Activation Response To Wounding Blood Coagulation Hemostasis Collagen Catabolic Process Locomotion Blood Vessel Development Platelet Degranulation Organ Morphogenesis Vasculature Development Collagen Metabolic Process Regulation Of Body Fluid Levels Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Cardiovascular System Development Response To Abiotic Stimulus Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Response To Hypoxia Cell Activation Tissue Development Response To Stress System Development Cellular Response To Growth Factor Stimulus Cell Migration Organ Development Bone Morphogenesis Response To Growth Factor Connective Tissue Development Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Collagen Fibril Organization Multicellular Organismal Development Anatomical Structure Development Vesicle-mediated Transport Endochondral Bone Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Exocytosis Response To Transforming Growth Factor Beta Skeletal System Development Regulation Of Blood Coagulation Positive Regulation Of Kidney Development Cartilage Development Involved In Endochondral Bone Morphogenesis Leukocyte Migration Developmental Process Bone Development
Tagcloud ?		akathisia bradykinesia drd3 drd4 dyskinesia dystonia fluctuating grin2a grin2b htr2c naturalistic nominal orofacial parkinsonism preferably rater rs10772715 rs11644461 rs11866328 rs1345423 rs1650420 rs2192970 rs324035 rs4911871 rs7192557 tardive td tremor truncal	aggregation chaperone chaperones combining concert culturing dependency divergent dnakj entirely ethanol exhibiting facilitated flask folding galactosidase grown hsps inoculation operon overexpressing overproduction pres2 prone shake simply supplementation upregulate yields
Tagcloud (Difference) ?		akathisia bradykinesia drd3 drd4 dyskinesia dystonia fluctuating grin2a grin2b htr2c naturalistic nominal orofacial parkinsonism preferably rater rs10772715 rs11644461 rs11866328 rs1345423 rs1650420 rs2192970 rs324035 rs4911871 rs7192557 tardive td tremor truncal	aggregation chaperone chaperones combining concert culturing dependency divergent dnakj entirely ethanol exhibiting facilitated flask folding galactosidase grown hsps inoculation operon overexpressing overproduction pres2 prone shake simply supplementation upregulate yields
Tagcloud (Intersection) ?