HSPG2 and COL13A1

Number of citations: 0 (PubMedID 11956183)
Data Source: HPRD (in vitro)

		HSPG2	COL13A1
Name		heparan sulfate proteoglycan 2	collagen type XIII alpha 1 chain
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Extracellular Matrix Neuron Projection Lysosomal Lumen Extracellular Exosome Plasma Membrane Protein Complex	Extracellular Region Collagen Trimer Collagen Type XIII Trimer Basement Membrane Endoplasmic Reticulum Lumen Plasma Membrane Membrane Extracellular Matrix Synapse Postsynaptic Membrane
	Molecular Function	Amyloid-beta Binding Integrin Binding Calcium Ion Binding Protein Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Collagen V Binding	Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Angiogenesis Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Lipid Metabolic Process Receptor-mediated Endocytosis Inflammatory Response Negative Regulation Of Cell Adhesion Smoothened Signaling Pathway Brain Development Embryo Implantation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Negative Regulation Of Angiogenesis Cell Differentiation Animal Organ Regeneration Negative Regulation Of Neuron Apoptotic Process Circulatory System Development Negative Regulation Of Amyloid Fibril Formation	Ossification Morphogenesis Of A Branching Structure Endochondral Ossification Cell Adhesion Cell-matrix Adhesion Cell Differentiation Cell-cell Adhesion
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Non-integrin membrane-ECM interactions ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Amyloid fiber formation Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Formation of the dystrophin-glycoprotein complex (DGC)	Collagen degradation Collagen biosynthesis and modifying enzymes Integrin cell surface interactions Collagen chain trimerization
Drugs		Palifermin	None
Diseases		Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses	None
GWAS		Atrial fibrillation ( 30061737 ) Cerebral microbleeds (lobar) ( 32913026 ) Height ( 28552196 ) PR interval ( 32439900 )	Adverse response to drug ( 30420678 ) Antidepressant treatment resistance (number of drugs prescribed) ( 30700811 ) Carboplatin disposition in epthelial ovarian cancer ( 29367611 ) CSF tryptophan concentration in tuberculous meningitis ( 29395996 ) Early childhood aggressive behavior ( 26087016 ) Middle childhood and early adolescence aggressive behavior ( 26087016 ) Non-alcoholic fatty liver disease histology (lobular) ( 20708005 ) Optic disc size ( 31809533 ) Parkinson's disease ( 23793441 ) PR interval ( 32439900 ) Response to fenofibrate (total cholesterol levels) ( 27002377 ) Triglyceride levels in HIV infection ( 33109212 ) Ulcerative colitis ( 25082827 ) Upper eyelid morphology ( 29921221 )
Interacting Genes		33 interacting genes: APP ATF7IP ATN1 BMP1 CACNA1A CCN2 COL13A1 ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN HSP90AA1 ITGA2 ITGB1 LAMA1 MTDH NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TCAP TTR UBC VWA1	7 interacting genes: FN1 HSPG2 ITGA1 MTDH NID1 NID2 SPARC
Entrez ID		3339	1305
HPRD ID		00804	00383
Ensembl ID		ENSG00000142798	ENSG00000197467
Uniprot IDs		P98160	A0A2R8YGI3 A0A669KB16 A0A669KB28 A0A6E1W314 Q5TAT6
PDB IDs		3SH4 3SH5	Not available
GO Terms Enriched among Interactors		Extracellular Matrix Structural Constituent Extracellular Matrix Extracellular Region Extracellular Space Basement Membrane Heparin Binding Collagen Binding Positive Regulation Of Cell Migration Integrin Binding Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Cell-matrix Adhesion Regulation Of Cell Motility Regulation Of Locomotion Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Platelet Alpha Granule Lumen Regulation Of Endothelial Cell Proliferation Chemoattractant Activity Growth Factor Activity Peptidase Activator Activity Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Endoplasmic Reticulum Lumen Integrin-mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Positive Chemotaxis Positive Regulation Of Cell Communication Positive Regulation Of Epithelial Cell Proliferation Response To Wounding Positive Regulation Of Endothelial Cell Migration Cell Adhesion Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Developmental Process Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Animal Organ Development	Collagen Binding Basement Membrane Cell-matrix Adhesion Extracellular Matrix Structural Constituent Extracellular Matrix Cell-substrate Adhesion Proteoglycan Binding Calcium Ion Binding Extracellular Matrix Binding Basement Membrane Organization Regulation Of Anatomical Structure Morphogenesis Cell Adhesion Regulation Of Vasculature Development Regulation Of Angiogenesis Platelet Alpha Granule Lumen Extracellular Exosome Extracellular Region Integrin-mediated Signaling Pathway Collagen V Binding Integrin Alpha1-beta1 Complex Regulation Of Developmental Process Negative Regulation Of Monocyte Activation Regulation Of Multicellular Organismal Development Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Calcium-independent Cell-matrix Adhesion Integrin Binding Extracellular Space Regulation Of Endothelial Cell Proliferation Positive Regulation Of Signal Transduction Collagen Binding Involved In Cell-matrix Adhesion Regulation Of Cell Population Proliferation Neural Crest Cell Migration Involved In Autonomic Nervous System Development Negative Regulation Of Cell Population Proliferation Phosphatase Activator Activity Intercellular Canaliculus Positive Regulation Of Cell Communication Regulation Of Cell Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signaling Fibrinogen Complex Regulation Of Cell-substrate Adhesion Regulation Of Basement Membrane Organization Laminin-1 Binding Semicircular Canal Morphogenesis Peptidase Activator Activity Blood Coagulation, Fibrin Clot Formation Protein Complex Involved In Cell-matrix Adhesion