HSPG2 and FBN1

Number of citations of the paper that reports this interaction (PubMedID 15657057)
0

Data Source:
HPRD (in vitro)

		HSPG2	FBN1
Description		heparan sulfate proteoglycan 2	fibrillin 1
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Extracellular Matrix Neuron Projection Lysosomal Lumen Extracellular Exosome Plasma Membrane Protein Complex	Microfibril Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Amyloid-beta Binding Integrin Binding Calcium Ion Binding Protein Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Collagen V Binding	Integrin Binding Hormone Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding Extracellular Matrix Constituent Conferring Elasticity Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Angiogenesis Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Lipid Metabolic Process Receptor-mediated Endocytosis Inflammatory Response Negative Regulation Of Cell Adhesion Smoothened Signaling Pathway Brain Development Embryo Implantation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Negative Regulation Of Angiogenesis Cell Differentiation Animal Organ Regeneration Negative Regulation Of Neuron Apoptotic Process Circulatory System Development Negative Regulation Of Amyloid Fibril Formation	Skeletal System Development Metanephros Development Kidney Development Glucose Metabolic Process Signal Transduction Heart Development Gene Expression Protein Kinase A Signaling Lung Development Positive Regulation Of Appetite Cell Adhesion Mediated By Integrin Activation Of Protein Kinase A Activity Sequestering Of BMP In Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Glucose Homeostasis Camera-type Eye Development Negative Regulation Of Osteoclast Differentiation Embryonic Eye Morphogenesis Post-embryonic Eye Morphogenesis Lung Alveolus Development Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Osteoclast Development
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Non-integrin membrane-ECM interactions ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Amyloid fiber formation Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Formation of the dystrophin-glycoprotein complex (DGC)	Degradation of the extracellular matrix Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Palifermin
Diseases		Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses	Geleophysic dysplasia Weill-Marchesani syndrome, including: Weill-Marchesani syndrome; Weill-Marchesani-like syndrome Shprintzen-Goldberg syndrome Ectopia lentis MASS phenotype Marfan syndrome, including: Marfan syndrome (MFS); Neonatal MFS; Atypically severe MFS; New variant of MFS
GWAS		Atrial fibrillation ( 30061737) Cerebral microbleeds (lobar) ( 32913026) Height ( 28552196) PR interval ( 32439900)	Breast cancer ( 17903305) Central corneal thickness ( 32528159 29760442) Height ( 32499652 31562340) Hepcidin/ferritin ratio ( 27846281) Hip circumference adjusted for BMI ( 34021172 28552196) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Intraocular pressure ( 29617998) Macular thickness ( 30535121) Pulse pressure ( 28739976 30578418 27841878) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Refractive error ( 32231278) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Spontaneous coronary artery dissection ( 32374345) Systolic blood pressure ( 27841878 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Thoracic aortic aneurysms and dissections ( 21909107) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		33 interacting genes: APP ATF7IP ATN1 BMP1 CACNA1A CCN2 COL13A1 ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN HSP90AA1 ITGA2 ITGB1 LAMA1 MTDH NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TCAP TTR UBC VWA1	18 interacting genes: ATXN7 CALR DCN DYRK1A ELN FBLN2 FBN2 GET4 HGS HOXA1 HSPG2 LTBP1 MFAP2 MFAP5 MYOC SGTB SPRY2 VCAN
Entrez ID		3339	2200
HPRD ID		00804	00618
Ensembl ID		ENSG00000142798	ENSG00000166147
Uniprot IDs		P98160	P35555
PDB IDs		3SH4 3SH5	1APJ 1EMN 1EMO 1LMJ 1UZJ 1UZK 1UZP 1UZQ 2M74 2W86 5MS9
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Structural Constituent Extracellular Matrix Extracellular Region Extracellular Space Basement Membrane Heparin Binding Collagen Binding Positive Regulation Of Cell Migration Integrin Binding Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Cell-matrix Adhesion Regulation Of Cell Motility Regulation Of Locomotion Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Platelet Alpha Granule Lumen Regulation Of Endothelial Cell Proliferation Chemoattractant Activity Growth Factor Activity Peptidase Activator Activity Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Endoplasmic Reticulum Lumen Integrin-mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Positive Chemotaxis Positive Regulation Of Cell Communication Positive Regulation Of Epithelial Cell Proliferation Response To Wounding Positive Regulation Of Endothelial Cell Migration Cell Adhesion Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Developmental Process Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Animal Organ Development	Microfibril Extracellular Matrix Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Structural Constituent Conferring Compression Resistance Negative Regulation Of Supramolecular Fiber Organization Sequestering Of TGFbeta In Extracellular Matrix Embryonic Eye Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Extracellular Matrix Binding Protein-folding Chaperone Binding Extracellular Region Regulation Of Supramolecular Fiber Organization Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Cytoskeleton Organization Sequestering Of Extracellular Ligand From Receptor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Eye Morphogenesis Animal Organ Morphogenesis Extracellular Negative Regulation Of Signal Transduction Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Sensory Organ Morphogenesis Positive Regulation Of Membrane Depolarization Calcium Ion Binding Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Maintenance Of Location Regulation Of Trophoblast Cell Migration Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Lysosomal Lumen Embryonic Morphogenesis Golgi Lumen Regulation Of Mitochondrial Depolarization Glycosaminoglycan Binding Negative Regulation Of Cellular Component Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Cellular Response To Growth Factor Stimulus Embryonic Organ Morphogenesis Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Fibronectin Binding Protein Targeting To ER Regulation Of Cytoskeleton Organization Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Metabolic Process
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