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HSPG2 and PDGFB
Number of citations of the paper that reports this interaction (PubMedID
9692901
)
0
Data Source:
HPRD
(in vitro)
HSPG2
PDGFB
Description
heparan sulfate proteoglycan 2
platelet derived growth factor subunit B
Image
GO Annotations
Cellular Component
Extracellular Region
Basement Membrane
Extracellular Space
Golgi Lumen
Plasma Membrane
Focal Adhesion
Extracellular Matrix
Neuron Projection
Lysosomal Lumen
Extracellular Exosome
Plasma Membrane Protein Complex
Golgi Membrane
Extracellular Region
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Golgi Lumen
Cell Surface
Membrane
Basolateral Plasma Membrane
Extracellular Matrix
Platelet Alpha Granule Lumen
Platelet-derived Growth Factor Complex
Molecular Function
Amyloid-beta Binding
Integrin Binding
Calcium Ion Binding
Protein Binding
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Metal Ion Binding
Low-density Lipoprotein Particle Receptor Binding
Collagen V Binding
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Collagen Binding
Growth Factor Activity
Superoxide-generating NADPH Oxidase Activator Activity
Chemoattractant Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Receptor Ligand Activity
Platelet-derived Growth Factor Binding
Biological Process
Angiogenesis
Response To Hypoxia
Positive Regulation Of Endothelial Cell Proliferation
Lipid Metabolic Process
Receptor-mediated Endocytosis
Inflammatory Response
Negative Regulation Of Cell Adhesion
Smoothened Signaling Pathway
Brain Development
Embryo Implantation
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Negative Regulation Of Angiogenesis
Cell Differentiation
Animal Organ Regeneration
Negative Regulation Of Neuron Apoptotic Process
Circulatory System Development
Negative Regulation Of Amyloid Fibril Formation
Angiogenesis
Embryonic Placenta Development
Positive Regulation Of Endothelial Cell Proliferation
Monocyte Chemotaxis
Positive Regulation Of Glomerular Filtration
Protein Phosphorylation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Heart Development
Positive Regulation Of Cell Population Proliferation
Response To Wounding
Gene Expression
Regulation Of Gene Expression
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Negative Regulation Of Platelet Activation
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Cell-substrate Adhesion
Smooth Muscle Adaptation
Positive Regulation Of Smooth Muscle Cell Migration
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Autophosphorylation
Intracellular Signal Transduction
Interleukin-18-mediated Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Cellular Response To Platelet-derived Growth Factor Stimulus
Paracrine Signaling
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Mitotic Nuclear Division
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Chemotaxis
Positive Regulation Of Chemotaxis
Regulation Of Multicellular Organismal Process
Positive Regulation Of Cell Division
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cell Chemotaxis
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Cellular Response To Mycophenolic Acid
Positive Regulation Of Glomerular Mesangial Cell Proliferation
Metanephric Glomerular Mesangial Cell Development
Reactive Oxygen Species Metabolic Process
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Hyaluronan Biosynthetic Process
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of MiRNA Transcription
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Metanephric Mesenchymal Cell Migration
Pathways
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Glycosaminoglycan-protein linkage region biosynthesis
HS-GAG biosynthesis
HS-GAG biosynthesis
HS-GAG degradation
Integrin cell surface interactions
Laminin interactions
Laminin interactions
Non-integrin membrane-ECM interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Attachment and Entry
Attachment and Entry
Retinoid metabolism and transport
Amyloid fiber formation
Respiratory syncytial virus (RSV) attachment and entry
RSV-host interactions
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Formation of the dystrophin-glycoprotein complex (DGC)
Platelet degranulation
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
Non-integrin membrane-ECM interactions
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Palifermin
Pegpleranib
Diseases
Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
Glioma
Malignant pleural mesothelioma
GWAS
Atrial fibrillation (
30061737
)
Cerebral microbleeds (lobar) (
32913026
)
Height (
28552196
)
PR interval (
32439900
)
Primary biliary cholangitis (
26394269
)
Primary biliary cirrhosis (
22961000
)
Interacting Genes
33 interacting genes:
APP
ATF7IP
ATN1
BMP1
CACNA1A
CCN2
COL13A1
ECM1
FBLN1
FBLN2
FBN1
FGF2
FGF7
FGFBP1
FN1
GFI1B
GRN
HSP90AA1
ITGA2
ITGB1
LAMA1
MTDH
NID1
NID2
PDGFA
PDGFB
PRELP
PRPF40A
SPARC
TCAP
TTR
UBC
VWA1
23 interacting genes:
A2M
ART1
BCCIP
COL1A1
COL1A2
COL2A1
COL3A1
COL4A1
COL5A1
COL6A1
FBXO7
HNRNPC
HRAS
HSPG2
LRP1
LYVE1
MDFI
PDAP1
PDGFRA
PDGFRB
PIK3R1
SPARC
THBS1
Entrez ID
3339
5155
HPRD ID
00804
01815
Ensembl ID
ENSG00000142798
ENSG00000100311
Uniprot IDs
P98160
A0A384NYY3
P01127
PDB IDs
3SH4
3SH5
1PDG
3MJG
4HQU
4HQX
4QCI
6T9E
Enriched GO Terms of Interacting Partners
?
Extracellular Matrix Structural Constituent
Extracellular Matrix
Extracellular Region
Extracellular Space
Basement Membrane
Heparin Binding
Collagen Binding
Positive Regulation Of Cell Migration
Integrin Binding
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Regulation Of Cell Migration
Cell-matrix Adhesion
Regulation Of Cell Motility
Regulation Of Locomotion
Cell-substrate Adhesion
Extracellular Matrix Organization
Extracellular Structure Organization
Regulation Of Multicellular Organismal Process
Regulation Of Developmental Process
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Platelet Alpha Granule Lumen
Regulation Of Endothelial Cell Proliferation
Chemoattractant Activity
Growth Factor Activity
Peptidase Activator Activity
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of ERK1 And ERK2 Cascade
Endoplasmic Reticulum Lumen
Integrin-mediated Signaling Pathway
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Angiogenesis
Positive Chemotaxis
Positive Regulation Of Cell Communication
Positive Regulation Of Epithelial Cell Proliferation
Response To Wounding
Positive Regulation Of Endothelial Cell Migration
Cell Adhesion
Regulation Of Anatomical Structure Morphogenesis
Positive Regulation Of Developmental Process
Platelet-derived Growth Factor Complex
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Cell-substrate Adhesion
Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Epithelial Cell Proliferation
Animal Organ Development
Platelet-derived Growth Factor Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Collagen Trimer
Extracellular Matrix
Fibrillar Collagen Trimer
Extracellular Matrix Structural Constituent
Basement Membrane
Anatomical Structure Morphogenesis
Endoplasmic Reticulum Lumen
Collagen Fibril Organization
Developmental Process
Extracellular Matrix Organization
Extracellular Structure Organization
Cellular Response To Amino Acid Stimulus
Phospholipase C Activator Activity
Regulation Of Locomotion
Response To Amino Acid
Enzyme-linked Receptor Protein Signaling Pathway
Animal Organ Morphogenesis
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Regulation Of Cell Motility
Positive Regulation Of Locomotion
Anatomical Structure Formation Involved In Morphogenesis
Angiogenesis
Extracellular Region
Protease Binding
Proteoglycan Binding
Skin Development
Cell Differentiation
Collagen Type I Trimer
Collagen V Binding
Cellular Developmental Process
Collagen Metabolic Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Metanephric Glomerular Capillary Formation
Kinase Regulator Activity
Positive Regulation Of Smooth Muscle Cell Proliferation
Extracellular Matrix Assembly
Cell Surface Receptor Signaling Pathway
Response To Wounding
Vascular Endothelial Growth Factor Binding
Basement Membrane Organization
Blood Vessel Morphogenesis
Cartilage Development
Collagen Type XI Trimer
Skeletal System Morphogenesis
Cell Adhesion
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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