HSPG2 and ECM1

Number of citations of the paper that reports this interaction (PMID 12604605)
21

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		HSPG2	ECM1
Gene Name		heparan sulfate proteoglycan 2	extracellular matrix protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basal Lamina Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Extracellular Matrix Lysosomal Lumen Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Metal Ion Binding	Protease Binding Signal Transducer Activity Interleukin-2 Receptor Binding Protein Binding Protein C-terminus Binding Enzyme Binding Laminin Binding
	Biological Process	Retinoid Metabolic Process Angiogenesis Endochondral Ossification Chondrocyte Differentiation Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Brain Development Phototransduction, Visible Light Protein Localization Pathogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Lipoprotein Metabolic Process Small Molecule Metabolic Process Embryonic Skeletal System Morphogenesis Cardiac Muscle Tissue Development Cartilage Development Involved In Endochondral Bone Morphogenesis	Ossification Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Type 2 Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Inflammatory Response Signal Transduction Negative Regulation Of Peptidase Activity Negative Regulation Of Bone Mineralization Biomineral Tissue Development Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Angiogenesis Regulation Of T Cell Migration
Pathways		Lipoprotein metabolism Metabolism of lipids and lipoproteins MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Degradation of the extracellular matrix Amyloids Defective CHST14 causes EDS, musculocontractural type Laminin interactions Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Glycogen storage diseases Defective CHST6 causes MCDC1 Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 Diseases associated with visual transduction MPS IV - Morquio syndrome A Integrin cell surface interactions Metabolism of carbohydrates HS-GAG biosynthesis MPS VI - Maroteaux-Lamy syndrome MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type Chylomicron-mediated lipid transport Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Lipid digestion, mobilization, and transport Non-integrin membrane-ECM interactions Defective EXT1 causes exostoses 1, TRPS2 and CHDS Visual phototransduction Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome HS-GAG degradation
Drugs		Palifermin
Diseases
GWAS
Protein-Protein Interactions		29 interactors: APP ATF7IP ATN1 BMP1 CACNA1A COL13A1 CTGF ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN ITGA2 ITGB1 LAMA1 NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TTR VWA1	8 interactors: ATN1 BNIP3L CPTP FBLN1 HSPG2 IRAK3 RERE SRPK1
Entrez ID		3339	1893
HPRD ID		00804	03727
Ensembl ID		ENSG00000142798	ENSG00000143369
Uniprot IDs		P98160	Q16610
PDB IDs		3SH4 3SH5
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Multicellular Organismal Development Cell-matrix Adhesion System Development Developmental Process Anatomical Structure Development Cell-substrate Adhesion Response To Wounding Organ Development Locomotion Regulation Of Cell Migration Positive Regulation Of Cell Proliferation Platelet Degranulation Blood Vessel Morphogenesis Regulation Of Cell Motility Cardiovascular System Development Positive Regulation Of Epithelial Cell Migration Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Extracellular Matrix Disassembly Positive Regulation Of Cell Motility Blood Vessel Development Secretion By Cell Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Vasculature Development Anatomical Structure Morphogenesis Response To Growth Factor Wound Healing Positive Regulation Of Cellular Protein Metabolic Process Chemotaxis Regulation Of Cell Proliferation Blood Coagulation Secretion Hemostasis Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Epithelial Cell Proliferation Regulation Of Cellular Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol Biosynthetic Process Organ Morphogenesis Angiogenesis Tissue Development Exocytosis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor	Positive Regulation Of Macrophage Tolerance Induction Ceramide 1-phosphate Transport Viral Process Mitochondrial Protein Catabolic Process Negative Regulation Of Macrophage Cytokine Production Ceramide Transport
Tagcloud ?		akathisia bradykinesia drd3 drd4 dyskinesia dystonia fluctuating grin2a grin2b htr2c naturalistic nominal orofacial parkinsonism preferably rater rs10772715 rs11644461 rs11866328 rs1345423 rs1650420 rs2192970 rs324035 rs4911871 rs7192557 tardive td tremor truncal	aberration additionally asn condition contrary defect defective derived extracellular glycan glycosylated glycosylation lipoid lp matrix mutants mutated negatively origin proteinosis putative rare residues secretion sites spectrometry suppresses variety wide
Tagcloud (Difference) ?		akathisia bradykinesia drd3 drd4 dyskinesia dystonia fluctuating grin2a grin2b htr2c naturalistic nominal orofacial parkinsonism preferably rater rs10772715 rs11644461 rs11866328 rs1345423 rs1650420 rs2192970 rs324035 rs4911871 rs7192557 tardive td tremor truncal	aberration additionally asn condition contrary defect defective derived extracellular glycan glycosylated glycosylation lipoid lp matrix mutants mutated negatively origin proteinosis putative rare residues secretion sites spectrometry suppresses variety wide
Tagcloud (Intersection) ?