TNIK and MACF1

Number of citations of the paper that reports this interaction (PubMedID 17043677)
0

Data Source:
BioGRID (two hybrid)

		TNIK	MACF1
Description		TRAF2 and NCK interacting kinase	microtubule actin crosslinking factor 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Exosome Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Cytoplasm Golgi Apparatus Cytoskeleton Microtubule Intermediate Filament Plasma Membrane Actin Cytoskeleton Membrane Cell Leading Edge Ruffle Membrane Cell Projection
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	RNA Binding Actin Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Microtubule Binding Cadherin Binding Metal Ion Binding Microtubule Minus-end Binding Actin Filament Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Cytoskeleton Organization Nervous System Development Wnt Signaling Pathway Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis Regulation Of Dendrite Morphogenesis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Microvillus Assembly	Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Projection Organization Regulation Of Microtubule-based Process Wound Healing Golgi To Plasma Membrane Protein Transport Intermediate Filament Cytoskeleton Organization Positive Regulation Of Axon Extension Regulation Of Multicellular Organismal Process Regulation Of Focal Adhesion Assembly Establishment Of Protein Localization To Membrane Regulation Of Neuron Projection Arborization
Pathways		Oxidative Stress Induced Senescence
Drugs		Fostamatinib
Diseases
GWAS		Adolescent idiopathic scoliosis ( 28334814) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid AB1-42 levels ( 29274321) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cortical surface area (MOSTest) ( 32665545) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136) Frontotemporal dementia (age at onset) ( 29724592) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference adjusted for BMI ( 28552196) LDL cholesterol ( 21347282) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Night sleep phenotypes ( 27126917) Response to antipsychotic treatment in schizophrenia ( 29503163) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458)	Adult body size ( 32376654) Beard thickness ( 26926045) Body mass index ( 29273807) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Colorectal cancer ( 27207650) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol ( 20686565 25961943) Headache ( 29397368) Heel bone mineral density ( 30598549) Loneliness (multivariate analysis) ( 27629369) Mean corpuscular hemoglobin concentration ( 27863252) Optic disc size ( 31809533) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Platelet distribution width ( 32888494) PR interval ( 32439900) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458 27189021 28869590 29358691 32499647 29632382 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382) Ventral thalamic nuclei volume ( 34006833)
Interacting Genes		39 interacting genes: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS1 MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SMARCE1 SMURF1 SNX6 SOS1 SPTBN1 SRGAP3 STRIP1 STRN4 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1	38 interacting genes: ACTA1 APC ATF7IP CDC5L CEP63 CNTNAP2 CNTNAP4 DISC1 DSCAM DSCR9 DTNBP1 ESRRA EXOC1 FHL1 GOLGA4 JUN LCOR MAPK9 MAPRE1 MTNR1B NRCAM NRIP1 NRXN1 NRXN2 PCNT PKNOX1 PLXND1 PRKCD RIPK4 SKIL SNAPIN SRPK2 TANGO6 TENM1 TNIK TRAF3IP1 UBC USP7
Entrez ID		23043	23499
HPRD ID		18206	09750
Ensembl ID		ENSG00000154310	ENSG00000127603
Uniprot IDs		Q9UKE5	H3BPE1 O94854 Q6ZSD7 Q9UPN3
PDB IDs		2X7F 5AX9 5CWZ 5D7A 6RA5 6RA7 7XZQ 7XZR 8WM0 8X88	4Z6G 5VE9 5X57
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Regulation Of Cellular Component Organization Cytoplasm Positive Regulation Of Cellular Component Organization Cytoskeleton Organelle Organization Retrograde Axonal Transport Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Cytosol Positive Regulation Of Cell Projection Organization Positive Regulation Of Axon Extension Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Supramolecular Fiber Organization Structural Constituent Of Cytoskeleton Positive Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Signal Transduction Axon Cytoplasm Regulation Of Plasma Membrane Bounded Cell Projection Organization Axonal Transport Regulation Of Cell Communication Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Axonogenesis Negative Regulation Of Hippo Signaling Axo-dendritic Transport Regulation Of Axon Extension Glutamatergic Synapse Regulation Of Protein-containing Complex Assembly Neurofibrillary Tangle Extrinsic Component Of Postsynaptic Density Membrane Cell Cortex Regulation Of Signaling Microtubule Cytoskeleton Organization Protein Localization To Plasma Membrane Potassium Channel Activator Activity Regulation Of Intracellular Signal Transduction Dihydropyrimidinase Activity Golgi To Plasma Membrane Protein Transport Maintenance Of Centrosome Location Cellular Localization Establishment Of Protein Localization Extracellular Exosome Supramolecular Fiber Organization Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Protein Transport Microtubule Protein-macromolecule Adaptor Activity	Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Neuron Projection Development Positive Regulation Of Cellular Component Organization Vocal Learning Positive Regulation Of Axonogenesis Observational Learning Positive Regulation Of Cell Projection Organization Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Synapse Assembly Neuron Recognition Auditory Behavior Mechanosensory Behavior Social Behavior Vocalization Behavior Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Regulation Of Axonogenesis Cell Junction Assembly Neuron Projection Morphogenesis Positive Regulation Of Nervous System Development Regulation Of Axon Extension Glutamatergic Synapse Negative Regulation Of Filopodium Assembly Cell Projection Morphogenesis Anatomical Structure Morphogenesis Gephyrin Clustering Involved In Postsynaptic Density Assembly Neuroligin Family Protein Binding Angiogenesis Postsynaptic Density Protein 95 Clustering Neuron Projection Development Positive Regulation Of Axon Extension Modulation Of Chemical Synaptic Transmission Neurotransmitter Secretion Postsynaptic Membrane Assembly Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Neurogenesis Regulation Of Filopodium Assembly Regulation Of Cell Projection Assembly Synapse Cell Recognition Postsynaptic Membrane Organization Axon Synapse Organization Presynaptic Membrane Positive Regulation Of Intracellular Transport Neuronal Ion Channel Clustering Regulation Of Postsynapse Organization Cilium Assembly
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