MACF1 and NRXN2

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MACF1	NRXN2
Gene Name		microtubule-actin crosslinking factor 1	neurexin 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytoskeleton Microtubule Plasma Membrane Actin Cytoskeleton Ruffle Membrane	Integral Component Of Membrane
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Microtubule Binding ATPase Activity Poly(A) RNA Binding Actin Filament Binding	Calcium Channel Regulator Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Mesoderm Formation Posttranslational Protein Targeting To Membrane Movement Of Cell Or Subcellular Component Cell Cycle Arrest Establishment Or Maintenance Of Cell Polarity Metabolic Process Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Microtubule-based Process Wound Healing Golgi To Plasma Membrane Protein Transport Positive Regulation Of Axon Extension Regulation Of Focal Adhesion Assembly	Neuron Cell-cell Adhesion Synaptic Transmission Neurotransmitter Secretion Synapse Assembly Adult Behavior Social Behavior Vocal Learning Vocalization Behavior Postsynaptic Membrane Assembly Gephyrin Clustering Neuroligin Clustering Postsynaptic Density Protein 95 Clustering
Pathways
Drugs
Diseases
GWAS		HDL cholesterol ( 20686565)	Urate levels ( 21768215 23263486)
Protein-Protein Interactions		24 interactors: ACTA1 APC ATF7IP CDC5L CEP63 CNTNAP2 CNTNAP4 DISC1 DTNBP1 ESRRA EXOC1 GOLGA4 JUN MAPK9 MAPRE1 NRCAM NRXN1 NRXN2 PLXND1 PRKCD SKIL TANGO6 TNIK TRAF3IP1	9 interactors: CASK DDX24 INADL MACF1 MAPK6 MLLT4 NLGN1 NLGN2 NLGN3
Entrez ID		23499	9379
HPRD ID		09750	11859
Ensembl ID		ENSG00000127603	ENSG00000110076
Uniprot IDs		Q6ZSD7 Q9UPN3	G5E9G7 P58401 Q9P2S2
PDB IDs
Enriched GO Terms of Interacting Partners?		Nervous System Development Generation Of Neurons Neurogenesis Regulation Of Cell Projection Organization Cell Projection Organization System Development Developmental Process Multicellular Organismal Development Vocalization Behavior Protein Localization Regulation Of Cellular Component Organization Cellular Localization Neuron Projection Development Anatomical Structure Development Membrane Organization Synapse Assembly Neuroligin Clustering Organelle Organization Response To Mechanical Stimulus Neuron Development Cellular Protein Localization Gephyrin Clustering Cell Differentiation Signaling Cellular Component Assembly Cell Communication Negative Regulation Of Filopodium Assembly Neuron Differentiation Regulation Of Cell Differentiation Social Behavior Vocal Learning Learning Positive Regulation Of Cell Differentiation Postsynaptic Membrane Assembly Regulation Of Grooming Behavior Synapse Organization Cell Development Regulation Of Neuron Projection Development Postsynaptic Density Protein 95 Clustering Anatomical Structure Formation Involved In Morphogenesis Auditory Behavior Movement Of Cell Or Subcellular Component Regulation Of Signaling Neuronal Ion Channel Clustering Regulation Of Cell Morphogenesis Neuron Cell-cell Adhesion Positive Regulation Of Cell Development Regulation Of Binding Cell Projection Morphogenesis Learning Or Memory	Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynaptic Membrane Organization Regulation Of Respiratory Gaseous Exchange By Neurological System Process Neuron Cell-cell Adhesion Regulation Of Respiratory System Process Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Membrane Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Respiratory Gaseous Exchange Membrane Biogenesis Postsynaptic Membrane Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Excitatory Postsynaptic Membrane Potential Terminal Button Organization Positive Regulation Of Membrane Potential Regulation Of Synapse Assembly Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Synapse Assembly Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Postsynaptic Density Protein 95 Clustering Positive Regulation Of Synaptic Transmission Membrane Depolarization Regulation Of Receptor Activity Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission, GABAergic Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Protein Localization To Synapse Synapse Organization Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Cell Adhesion Regulation Of Ion Transport Cell-cell Junction Organization Regulation Of Synaptic Transmission, GABAergic Membrane Hyperpolarization Regulation Of Membrane Potential Regulation Of Dendritic Spine Development Regulation Of Synaptic Transmission Positive Regulation Of Cellular Component Biogenesis Membrane Organization Cell-cell Signaling Protein Localization To Membrane Cellular Component Assembly Regulation Of Neuron Projection Development Positive Regulation Of Ion Transmembrane Transport
Tagcloud ?		a2 comprehensive cytoskeleton ecm focal genotypes hbv hbx hcc hepatocellular hepg2 hmgb1 lamin lc migration ms nevertheless obscure platform preliminary profile proteasome proteomics psma3 s100a11 s100a4 s100a6 supported turn	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		a2 comprehensive cytoskeleton ecm focal genotypes hbv hbx hcc hepatocellular hepg2 hmgb1 lamin lc migration ms nevertheless obscure platform preliminary profile proteasome proteomics psma3 s100a11 s100a4 s100a6 supported turn	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?