MACF1 and PLXND1

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		MACF1	PLXND1
Gene Name		microtubule-actin crosslinking factor 1	plexin D1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytoskeleton Microtubule Plasma Membrane Actin Cytoskeleton Ruffle Membrane	Intracellular Plasma Membrane Integral Component Of Plasma Membrane Lamellipodium
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Microtubule Binding ATPase Activity Poly(A) RNA Binding Actin Filament Binding	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding
	Biological Process	Mesoderm Formation Posttranslational Protein Targeting To Membrane Movement Of Cell Or Subcellular Component Cell Cycle Arrest Establishment Or Maintenance Of Cell Polarity Metabolic Process Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Microtubule-based Process Wound Healing Golgi To Plasma Membrane Protein Transport Positive Regulation Of Axon Extension Regulation Of Focal Adhesion Assembly	Angiogenesis Patterning Of Blood Vessels Outflow Tract Morphogenesis Axon Guidance Synapse Assembly Regulation Of Cell Migration Positive Regulation Of Protein Binding Endothelial Cell Migration Regulation Of Angiogenesis Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Semaphorin-plexin Signaling Pathway
Pathways			Axon guidance Semaphorin interactions Other semaphorin interactions
Drugs
Diseases
GWAS		HDL cholesterol ( 20686565)
Protein-Protein Interactions		24 interactors: ACTA1 APC ATF7IP CDC5L CEP63 CNTNAP2 CNTNAP4 DISC1 DTNBP1 ESRRA EXOC1 GOLGA4 JUN MAPK9 MAPRE1 NRCAM NRXN1 NRXN2 PLXND1 PRKCD SKIL TANGO6 TNIK TRAF3IP1	2 interactors: MACF1 SEMA4A
Entrez ID		23499	23129
HPRD ID		09750	05046
Ensembl ID		ENSG00000127603	ENSG00000004399
Uniprot IDs		Q6ZSD7 Q9UPN3	Q9Y4D7
PDB IDs			3H6N
Enriched GO Terms of Interacting Partners?		Nervous System Development Generation Of Neurons Neurogenesis Regulation Of Cell Projection Organization Cell Projection Organization System Development Developmental Process Multicellular Organismal Development Vocalization Behavior Protein Localization Regulation Of Cellular Component Organization Cellular Localization Neuron Projection Development Anatomical Structure Development Membrane Organization Synapse Assembly Neuroligin Clustering Organelle Organization Response To Mechanical Stimulus Neuron Development Cellular Protein Localization Gephyrin Clustering Cell Differentiation Signaling Cellular Component Assembly Cell Communication Negative Regulation Of Filopodium Assembly Neuron Differentiation Regulation Of Cell Differentiation Social Behavior Vocal Learning Learning Positive Regulation Of Cell Differentiation Postsynaptic Membrane Assembly Regulation Of Grooming Behavior Synapse Organization Cell Development Regulation Of Neuron Projection Development Postsynaptic Density Protein 95 Clustering Anatomical Structure Formation Involved In Morphogenesis Auditory Behavior Movement Of Cell Or Subcellular Component Regulation Of Signaling Neuronal Ion Channel Clustering Regulation Of Cell Morphogenesis Neuron Cell-cell Adhesion Positive Regulation Of Cell Development Regulation Of Binding Cell Projection Morphogenesis Learning Or Memory	Regulation Of Epithelial Cell Migration Regulation Of Cell Morphogenesis Posttranslational Protein Targeting To Membrane Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement T-helper 1 Cell Differentiation Golgi To Plasma Membrane Protein Transport Anatomical Structure Formation Involved In Morphogenesis T-helper 1 Type Immune Response T-helper Cell Differentiation Golgi To Plasma Membrane Transport CD4-positive, Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Axon Extension Semaphorin-plexin Signaling Pathway Regulation Of Focal Adhesion Assembly Movement Of Cell Or Subcellular Component Generation Of Neurons Alpha-beta T Cell Differentiation Regulation Of Cell Junction Assembly Neurogenesis Alpha-beta T Cell Activation T Cell Activation Involved In Immune Response Regulation Of Axon Extension Positive Regulation Of Axonogenesis Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Angiogenesis Regulation Of Cellular Component Organization Post-Golgi Vesicle-mediated Transport Mesoderm Formation Mesoderm Morphogenesis Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Endothelial Cell Migration Nervous System Development Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell Growth Protein Localization To Endoplasmic Reticulum Anatomical Structure Morphogenesis Formation Of Primary Germ Layer Regulation Of Cell Size Cell Cycle Arrest Mesoderm Development Protein Localization To Plasma Membrane T Cell Differentiation Leukocyte Activation Involved In Immune Response Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Developmental Growth
Tagcloud ?		a2 comprehensive cytoskeleton ecm focal genotypes hbv hbx hcc hepatocellular hepg2 hmgb1 lamin lc migration ms nevertheless obscure platform preliminary profile proteasome proteomics psma3 s100a11 s100a4 s100a6 supported turn
Tagcloud (Difference) ?		a2 comprehensive cytoskeleton ecm focal genotypes hbv hbx hcc hepatocellular hepg2 hmgb1 lamin lc migration ms nevertheless obscure platform preliminary profile proteasome proteomics psma3 s100a11 s100a4 s100a6 supported turn
Tagcloud (Intersection) ?