TNIK and AGTPBP1

Number of citations of the paper that reports this interaction (PubMedID 17043677)
0

Data Source:
BioGRID (two hybrid)

		TNIK	AGTPBP1
Description		TRAF2 and NCK interacting kinase	ATP/GTP binding carboxypeptidase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Exosome Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Cilium Microtubule Cytoskeleton Axon Centriolar Satellite Ciliary Basal Body Axon Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Carboxypeptidase Activity Metallocarboxypeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Tubulin Binding Hydrolase Activity Metal Ion Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Cytoskeleton Organization Nervous System Development Wnt Signaling Pathway Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis Regulation Of Dendrite Morphogenesis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Microvillus Assembly	Eye Photoreceptor Cell Differentiation Proteolysis Mitochondrion Organization Adult Walking Behavior Negative Regulation Of Cell Population Proliferation Cerebellum Development Cerebellar Purkinje Cell Layer Development Cerebellar Purkinje Cell Differentiation Olfactory Bulb Development Central Nervous System Neuron Development Protein Deglutamylation C-terminal Protein Deglutamylation Protein Side Chain Deglutamylation Neuromuscular Process Retina Development In Camera-type Eye Axonal Transport Anterograde Axonal Transport Of Mitochondrion Retrograde Axonal Transport Of Mitochondrion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Oxidative Stress Induced Senescence	Carboxyterminal post-translational modifications of tubulin
Drugs		Fostamatinib
Diseases
GWAS		Adolescent idiopathic scoliosis ( 28334814) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid AB1-42 levels ( 29274321) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cortical surface area (MOSTest) ( 32665545) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136) Frontotemporal dementia (age at onset) ( 29724592) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference adjusted for BMI ( 28552196) LDL cholesterol ( 21347282) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Night sleep phenotypes ( 27126917) Response to antipsychotic treatment in schizophrenia ( 29503163) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458)	General risk tolerance (MTAG) ( 30643258)
Interacting Genes		39 interacting genes: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS1 MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SMARCE1 SMURF1 SNX6 SOS1 SPTBN1 SRGAP3 STRIP1 STRN4 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1	13 interacting genes: CBY1 CYCS DISC1 ENO1 NYNRIN PPFIA1 PPFIA4 PYGM RSPH1 RUNX1 TNIK UBC VPS26C
Entrez ID		23043	23287
HPRD ID		18206	08442
Ensembl ID		ENSG00000154310	ENSG00000135049
Uniprot IDs		Q9UKE5	J3KNS1 Q9UPW5
PDB IDs		2X7F 5AX9 5CWZ 5D7A 6RA5 6RA7 7XZQ 7XZR 8WM0 8X88
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Regulation Of Cellular Component Organization Cytoplasm Positive Regulation Of Cellular Component Organization Cytoskeleton Organelle Organization Retrograde Axonal Transport Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Cytosol Positive Regulation Of Cell Projection Organization Positive Regulation Of Axon Extension Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Supramolecular Fiber Organization Structural Constituent Of Cytoskeleton Positive Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Signal Transduction Axon Cytoplasm Regulation Of Plasma Membrane Bounded Cell Projection Organization Axonal Transport Regulation Of Cell Communication Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Axonogenesis Negative Regulation Of Hippo Signaling Axo-dendritic Transport Regulation Of Axon Extension Glutamatergic Synapse Regulation Of Protein-containing Complex Assembly Neurofibrillary Tangle Extrinsic Component Of Postsynaptic Density Membrane Cell Cortex Regulation Of Signaling Microtubule Cytoskeleton Organization Protein Localization To Plasma Membrane Potassium Channel Activator Activity Regulation Of Intracellular Signal Transduction Dihydropyrimidinase Activity Golgi To Plasma Membrane Protein Transport Maintenance Of Centrosome Location Cellular Localization Establishment Of Protein Localization Extracellular Exosome Supramolecular Fiber Organization Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Protein Transport Microtubule Protein-macromolecule Adaptor Activity
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