MACF1 and GOLGA4

Number of citations of the paper that reports this interaction (PubMedID 15265687)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		MACF1	GOLGA4
Description		microtubule actin crosslinking factor 1	golgin A4
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytoskeleton Microtubule Intermediate Filament Plasma Membrane Actin Cytoskeleton Membrane Cell Leading Edge Ruffle Membrane Cell Projection	Golgi Membrane Nucleoplasm Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	RNA Binding Actin Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Microtubule Binding Cadherin Binding Metal Ion Binding Microtubule Minus-end Binding Actin Filament Binding	Protein Binding Small GTPase Binding GTPase Binding
	Biological Process	Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Projection Organization Regulation Of Microtubule-based Process Wound Healing Golgi To Plasma Membrane Protein Transport Intermediate Filament Cytoskeleton Organization Positive Regulation Of Axon Extension Regulation Of Multicellular Organismal Process Regulation Of Focal Adhesion Assembly Establishment Of Protein Localization To Membrane Regulation Of Neuron Projection Arborization	Vesicle-mediated Transport Golgi To Plasma Membrane Protein Transport Positive Regulation Of Axon Extension Golgi Vesicle Transport
Pathways			Retrograde transport at the Trans-Golgi-Network Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
Drugs
Diseases
GWAS		Adult body size ( 32376654) Beard thickness ( 26926045) Body mass index ( 29273807) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Colorectal cancer ( 27207650) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol ( 20686565 25961943) Headache ( 29397368) Heel bone mineral density ( 30598549) Loneliness (multivariate analysis) ( 27629369) Mean corpuscular hemoglobin concentration ( 27863252) Optic disc size ( 31809533) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Platelet distribution width ( 32888494) PR interval ( 32439900) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458 27189021 28869590 29358691 32499647 29632382 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382) Ventral thalamic nuclei volume ( 34006833)	Autism spectrum disorder or schizophrenia ( 28540026) Pulse pressure ( 30578418) Subjective response to lithium treatment ( 26503763)
Interacting Genes		38 interacting genes: ACTA1 APC ATF7IP CDC5L CEP63 CNTNAP2 CNTNAP4 DISC1 DSCAM DSCR9 DTNBP1 ESRRA EXOC1 FHL1 GOLGA4 JUN LCOR MAPK9 MAPRE1 MTNR1B NRCAM NRIP1 NRXN1 NRXN2 PCNT PKNOX1 PLXND1 PRKCD RIPK4 SKIL SNAPIN SRPK2 TANGO6 TENM1 TNIK TRAF3IP1 UBC USP7	11 interacting genes: APP ARL1 ARL3 CIP2A EIF4ENIF1 MACF1 RAB6A RNF10 SERPINB5 TNIK TRAF3IP1
Entrez ID		23499	2803
HPRD ID		09750	03941
Ensembl ID		ENSG00000127603	ENSG00000144674
Uniprot IDs		H3BPE1 O94854 Q6ZSD7 Q9UPN3	A0A8V8TPI8 A0A8V8TQI6 A0A9L9PX25 C9J0Y3 H0Y6I0 Q13439 Q49A56
PDB IDs		4Z6G 5VE9 5X57	1R4A 1UPT
Enriched GO Terms of Interacting Partners?		Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Neuron Projection Development Positive Regulation Of Cellular Component Organization Vocal Learning Positive Regulation Of Axonogenesis Observational Learning Positive Regulation Of Cell Projection Organization Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Synapse Assembly Neuron Recognition Auditory Behavior Mechanosensory Behavior Social Behavior Vocalization Behavior Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Regulation Of Axonogenesis Cell Junction Assembly Neuron Projection Morphogenesis Positive Regulation Of Nervous System Development Regulation Of Axon Extension Glutamatergic Synapse Negative Regulation Of Filopodium Assembly Cell Projection Morphogenesis Anatomical Structure Morphogenesis Gephyrin Clustering Involved In Postsynaptic Density Assembly Neuroligin Family Protein Binding Angiogenesis Postsynaptic Density Protein 95 Clustering Neuron Projection Development Positive Regulation Of Axon Extension Modulation Of Chemical Synaptic Transmission Neurotransmitter Secretion Postsynaptic Membrane Assembly Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Neurogenesis Regulation Of Filopodium Assembly Regulation Of Cell Projection Assembly Synapse Cell Recognition Postsynaptic Membrane Organization Axon Synapse Organization Presynaptic Membrane Positive Regulation Of Intracellular Transport Neuronal Ion Channel Clustering Regulation Of Postsynapse Organization Cilium Assembly	Endosome To Plasma Membrane Transport Vesicle Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Microtubule-based Transport Cellular Localization Trans-Golgi Network Membrane Ciliary Basal Body Intracellular Transport Microtubule-based Movement Protein Localization To Golgi Apparatus Establishment Of Localization In Cell Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Projection Organization Cytoplasm Organelle Organization Protein Transport Microtubule Binding Intraciliary Transport Cyclin D2-CDK6 Complex Peptidyl-cysteine Methylation Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Vesicle-mediated Transport Protein Localization To Organelle Centrosome Golgi Vesicle Transport Golgi To Plasma Membrane Transport Glial Cell Development Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Cell Projection Golgi Apparatus GTPase Activity Establishment Of Protein Localization Phospholipase D Activator Activity Protein Localization To Membrane Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Broken Chromosome Clustering Serine-type Endopeptidase Inhibitor Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Endothelin Production
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