TNIK and DPYSL3

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		TNIK	DPYSL3
Gene Name		TRAF2 and NCK interacting kinase	dihydropyrimidinase-like 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Vesicular Exosome	Extracellular Space Cytosol Lamellipodium Growth Cone Filamentous Actin Cell Body Exocytic Vesicle
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding	Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides SH3 Domain Binding Chondroitin Sulfate Binding Phosphoprotein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cytoskeleton Organization Activation Of JNKK Activity Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Reorganization Intracellular Signal Transduction Protein Autophosphorylation Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane	Pyrimidine Nucleobase Catabolic Process Axon Guidance Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Response To Axon Injury Actin Filament Bundle Assembly Protein Homooligomerization Positive Regulation Of Filopodium Assembly Actin Crosslink Formation Cellular Response To Cytokine Stimulus
Pathways		Oxidative Stress Induced Senescence Cellular Senescence	Axon guidance Semaphorin interactions CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Brain imaging in schizophrenia (interaction) ( 19023125) Coronary heart disease ( 21347282)
Protein-Protein Interactions		38 interactors: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DISC1 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SLC9A1 SMARCE1 SNX6 SOS1 SPTBN1 SRGAP3 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1	8 interactors: ACD CRMP1 DISC1 DPYSL2 DPYSL5 POT1 TERF1 TNIK
Entrez ID		23043	1809
HPRD ID		18206	03104
Ensembl ID		ENSG00000154310	ENSG00000113657
Uniprot IDs		Q9UKE5	Q14195 Q6DEN2 Q8IXW6
PDB IDs		2X7F	4BKN
Enriched GO Terms of Interacting Partners?		Neurogenesis Nervous System Development Cellular Component Assembly Movement Of Cell Or Subcellular Component Cell Differentiation Organelle Organization Generation Of Neurons Cytoskeleton Organization Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Locomotion Regulation Of Cell Projection Organization System Development Regulation Of Neuron Differentiation Anatomical Structure Development Endomembrane System Organization Regulation Of Cellular Component Size Signaling Multicellular Organismal Development Signal Transduction Cell Projection Organization Cell Communication Regulation Of Neurogenesis Cellular Localization Plasma Membrane Organization Regulation Of Signal Transduction Axonogenesis Developmental Process Positive Regulation Of Signal Transduction Axon Guidance Axon Development Cellular Response To Stimulus Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development Cell Morphogenesis Protein Localization To Plasma Membrane Cell Projection Morphogenesis Membrane Organization Regulation Of Cell Development Regulation Of Signaling Cell Part Morphogenesis Neuron Projection Morphogenesis Neuron Differentiation Golgi To Plasma Membrane Protein Transport Anatomical Structure Morphogenesis Establishment Of Protein Localization To Plasma Membrane Establishment Or Maintenance Of Cell Polarity Cell Development Protein Localization To Organelle Cell Morphogenesis Involved In Differentiation	Negative Regulation Of Telomere Maintenance Via Telomerase Pyrimidine Nucleobase Catabolic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Pyrimidine Nucleobase Metabolic Process Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Telomere Assembly Telomere Capping Telomere Maintenance Positive Regulation Of Telomerase Activity Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Regulation Of Cellular Component Organization Regulation Of DNA Replication Positive Regulation Of DNA Biosynthetic Process RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Regulation Of Chromosome Organization Telomere Maintenance Via Telomere Lengthening Generation Of Neurons Neurogenesis Organelle Organization Regulation Of Neuron Projection Development Positive Regulation Of DNA Replication Axon Guidance Developmental Process Cell Projection Organization Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation Nervous System Development Regulation Of Cell Projection Organization Locomotion Axonogenesis System Development Regulation Of Neuron Differentiation Homeostatic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Transferase Activity Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Movement Of Cell Or Subcellular Component Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase
Tagcloud ?		a549 attenuation carboxamide competition continuing crosstalk docking efforts emerging emt fak focal hinge ky methylbenzamido motility nck orchestrated paxillin pharmacologic phenylamino smad tgf thiazole traf2 transforming triggers validate wnt
Tagcloud (Difference) ?		a549 attenuation carboxamide competition continuing crosstalk docking efforts emerging emt fak focal hinge ky methylbenzamido motility nck orchestrated paxillin pharmacologic phenylamino smad tgf thiazole traf2 transforming triggers validate wnt
Tagcloud (Intersection) ?