TNIK and NEFM

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		TNIK	NEFM
Gene Name		TRAF2 and NCK interacting kinase	neurofilament, medium polypeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Vesicular Exosome	Neurofilament Axon Neuromuscular Junction Neurofibrillary Tangle
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cytoskeleton Organization Activation Of JNKK Activity Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Reorganization Intracellular Signal Transduction Protein Autophosphorylation Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane	Microtubule Cytoskeleton Organization Axon Cargo Transport Regulation Of Axon Diameter Neurofilament Bundle Assembly
Pathways		Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS		Brain imaging in schizophrenia (interaction) ( 19023125) Coronary heart disease ( 21347282)
Protein-Protein Interactions		38 interactors: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DISC1 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SLC9A1 SMARCE1 SNX6 SOS1 SPTBN1 SRGAP3 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1	9 interactors: APOE DISC1 FOS MINK1 NEFH RB1 SMAD2 STXBP1 TNIK
Entrez ID		23043	4741
HPRD ID		18206	01205
Ensembl ID		ENSG00000154310	ENSG00000104722
Uniprot IDs		Q9UKE5	E7EMV2 E7ESP9 P07197 Q9UK51
PDB IDs		2X7F
Enriched GO Terms of Interacting Partners?		Neurogenesis Nervous System Development Cellular Component Assembly Movement Of Cell Or Subcellular Component Cell Differentiation Organelle Organization Generation Of Neurons Cytoskeleton Organization Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Locomotion Regulation Of Cell Projection Organization System Development Regulation Of Neuron Differentiation Anatomical Structure Development Endomembrane System Organization Regulation Of Cellular Component Size Signaling Multicellular Organismal Development Signal Transduction Cell Projection Organization Cell Communication Regulation Of Neurogenesis Cellular Localization Plasma Membrane Organization Regulation Of Signal Transduction Axonogenesis Developmental Process Positive Regulation Of Signal Transduction Axon Guidance Axon Development Cellular Response To Stimulus Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development Cell Morphogenesis Protein Localization To Plasma Membrane Cell Projection Morphogenesis Membrane Organization Regulation Of Cell Development Regulation Of Signaling Cell Part Morphogenesis Neuron Projection Morphogenesis Neuron Differentiation Golgi To Plasma Membrane Protein Transport Anatomical Structure Morphogenesis Establishment Of Protein Localization To Plasma Membrane Establishment Or Maintenance Of Cell Polarity Cell Development Protein Localization To Organelle Cell Morphogenesis Involved In Differentiation	Cell Differentiation Nervous System Development System Development Generation Of Neurons Neurogenesis Multicellular Organismal Development Intracellular Signal Transduction Anatomical Structure Development Cytoskeleton Organization Cell Projection Organization Developmental Process Positive Regulation Of Cellular Metabolic Process Neuron Projection Development Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Neuron Development Cell Development Regulation Of Signaling Protein Localization Regulation Of Cellular Component Organization Organelle Organization Positive Regulation Of Cellular Protein Catabolic Process Neuron Differentiation Response To Cholesterol Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Protein Catabolic Process Cellular Protein Localization Cellular Localization MAPK Cascade Anatomical Structure Morphogenesis Signaling Cell Communication Cell Morphogenesis Involved In Differentiation Signal Transduction By Phosphorylation Positive Regulation Of Proteolysis Regulation Of Signal Transduction Positive Regulation Of Myeloid Leukocyte Differentiation SMAD Protein Signal Transduction Regulation Of Cell Development Skeletal Muscle Cell Differentiation Cell-cell Signaling Actin Cytoskeleton Reorganization Protein Localization To Membrane Regulation Of Neuron Projection Development Regulation Of Protein Catabolic Process Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process
Tagcloud ?		a549 attenuation carboxamide competition continuing crosstalk docking efforts emerging emt fak focal hinge ky methylbenzamido motility nck orchestrated paxillin pharmacologic phenylamino smad tgf thiazole traf2 transforming triggers validate wnt
Tagcloud (Difference) ?		a549 attenuation carboxamide competition continuing crosstalk docking efforts emerging emt fak focal hinge ky methylbenzamido motility nck orchestrated paxillin pharmacologic phenylamino smad tgf thiazole traf2 transforming triggers validate wnt
Tagcloud (Intersection) ?