MACF1 and CNTNAP2

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MACF1	CNTNAP2
Gene Name		microtubule-actin crosslinking factor 1	contactin associated protein-like 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytoskeleton Microtubule Plasma Membrane Actin Cytoskeleton Ruffle Membrane	Early Endosome Golgi Apparatus Voltage-gated Potassium Channel Complex Cell Surface Membrane Integral Component Of Membrane Axon Dendrite Axolemma Neuronal Cell Body Perikaryon Juxtaparanode Region Of Axon
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Microtubule Binding ATPase Activity Poly(A) RNA Binding Actin Filament Binding	Enzyme Binding
	Biological Process	Mesoderm Formation Posttranslational Protein Targeting To Membrane Movement Of Cell Or Subcellular Component Cell Cycle Arrest Establishment Or Maintenance Of Cell Polarity Metabolic Process Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Microtubule-based Process Wound Healing Golgi To Plasma Membrane Protein Transport Positive Regulation Of Axon Extension Regulation Of Focal Adhesion Assembly	Cell Adhesion Brain Development Learning Neuron Recognition Transmission Of Nerve Impulse Striatum Development Limbic System Development Thalamus Development Cerebral Cortex Development Adult Behavior Neuron Projection Development Cellular Protein Localization Social Behavior Clustering Of Voltage-gated Potassium Channels Superior Temporal Gyrus Development Protein Localization To Juxtaparanode Region Of Axon Vocalization Behavior
Pathways
Drugs
Diseases
GWAS		HDL cholesterol ( 20686565)	Alzheimer's disease ( 22159054) Bipolar disorder and schizophrenia ( 20889312) Body mass index (interaction) ( 23192594) Bone mineral density ( 17903296) Obesity-related traits ( 23251661) QT interval (interaction) ( 23459443) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		24 interactors: ACTA1 APC ATF7IP CDC5L CEP63 CNTNAP2 CNTNAP4 DISC1 DTNBP1 ESRRA EXOC1 GOLGA4 JUN MAPK9 MAPRE1 NRCAM NRXN1 NRXN2 PLXND1 PRKCD SKIL TANGO6 TNIK TRAF3IP1	8 interactors: CASK CNTN2 CTR9 EPB41L3 KCNA2 MACF1 MEOX2 ZMIZ1
Entrez ID		23499	26047
HPRD ID		09750	05197
Ensembl ID		ENSG00000127603	ENSG00000174469
Uniprot IDs		Q6ZSD7 Q9UPN3	B2RCH4 Q9UHC6
PDB IDs
Enriched GO Terms of Interacting Partners?		Nervous System Development Generation Of Neurons Neurogenesis Regulation Of Cell Projection Organization Cell Projection Organization System Development Developmental Process Multicellular Organismal Development Vocalization Behavior Protein Localization Regulation Of Cellular Component Organization Cellular Localization Neuron Projection Development Anatomical Structure Development Membrane Organization Synapse Assembly Neuroligin Clustering Organelle Organization Response To Mechanical Stimulus Neuron Development Cellular Protein Localization Gephyrin Clustering Cell Differentiation Signaling Cellular Component Assembly Cell Communication Negative Regulation Of Filopodium Assembly Neuron Differentiation Regulation Of Cell Differentiation Social Behavior Vocal Learning Learning Positive Regulation Of Cell Differentiation Postsynaptic Membrane Assembly Regulation Of Grooming Behavior Synapse Organization Cell Development Regulation Of Neuron Projection Development Postsynaptic Density Protein 95 Clustering Anatomical Structure Formation Involved In Morphogenesis Auditory Behavior Movement Of Cell Or Subcellular Component Regulation Of Signaling Neuronal Ion Channel Clustering Regulation Of Cell Morphogenesis Neuron Cell-cell Adhesion Positive Regulation Of Cell Development Regulation Of Binding Cell Projection Morphogenesis Learning Or Memory	Anatomical Structure Morphogenesis Protein Localization To Juxtaparanode Region Of Axon Multicellular Organismal Development Anatomical Structure Development Developmental Process System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Formation Involved In Morphogenesis Embryo Development Establishment Of Protein Localization To Juxtaparanode Region Of Axon Regulation Of Cell Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Adenosine Receptor Signaling Pathway Optic Nerve Structural Organization Vitellogenesis Positive Regulation Of Histone H3-K79 Methylation Regulation Of Cell-matrix Adhesion Formation Of Primary Germ Layer Positive Regulation Of Macromolecule Biosynthetic Process Clustering Of Voltage-gated Potassium Channels Positive Regulation Of Gene Expression Myelination Protein Localization To Plasma Membrane Axon Ensheathment Positive Regulation Of Cellular Biosynthetic Process Regulation Of Axonogenesis Gastrulation Regulation Of Cell-substrate Adhesion Protein Localization To Paranode Region Of Axon Somite Specification Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Axon Diameter Membrane Organization Plasma Membrane Organization Cell Differentiation Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Posttranslational Protein Targeting To Membrane Cytoplasm Organization Cerebral Cortex GABAergic Interneuron Migration Histone H2B Ubiquitination Regulation Of Cell Projection Size Interneuron Migration From The Subpallium To The Cortex Optic Nerve Morphogenesis Presynaptic Membrane Organization Wnt Signaling Pathway Cytoskeletal Anchoring At Plasma Membrane Negative Regulation Of Keratinocyte Proliferation Neuronal Ion Channel Clustering Paranodal Junction Assembly
Tagcloud ?		a2 comprehensive cytoskeleton ecm focal genotypes hbv hbx hcc hepatocellular hepg2 hmgb1 lamin lc migration ms nevertheless obscure platform preliminary profile proteasome proteomics psma3 s100a11 s100a4 s100a6 supported turn	acutely ameliorate asd autism cdfe contactin deficit deficits designer displays dreadd dysregulation epilepsy exclusively homolog hypothalamus immunoreactive knockout lasting melanocortin neuropeptide neuropsychiatric oxytocin paraventricular penetrance pvn rectify rescued windows
Tagcloud (Difference) ?		a2 comprehensive cytoskeleton ecm focal genotypes hbv hbx hcc hepatocellular hepg2 hmgb1 lamin lc migration ms nevertheless obscure platform preliminary profile proteasome proteomics psma3 s100a11 s100a4 s100a6 supported turn	acutely ameliorate asd autism cdfe contactin deficit deficits designer displays dreadd dysregulation epilepsy exclusively homolog hypothalamus immunoreactive knockout lasting melanocortin neuropeptide neuropsychiatric oxytocin paraventricular penetrance pvn rectify rescued windows
Tagcloud (Intersection) ?